The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 - Results from a prospective cohort of outpatient COVID-19 cases
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved..
Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined timepoints for up to one year. RT-PCR and viral culture were performed and seroresponses measured. Participants were classified applying the WHO clinical progression scale. Short symptom to test time (median 5.0 days; p = 0.0016) and high viral loads (VL; median maximum VL: 3∙108 copies/mL; p = 0.0015) were indicative for viral culture positivity. Participants with WHO grade 3 at baseline had significantly higher VLs compared to those with WHO 1 and 2 (p = 0.01). VLs dropped fast within 1 week of symptom onset. Maximum VLs were positively correlated with the magnitude of Ro-N-Ig seroresponse (p = 0.022). Our results describe the dynamics of VLs and antibodies to SARS-CoV-2 in mild to moderate cases that can support public health measures during the ongoing global pandemic.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:569 |
---|---|
Enthalten in: |
Virology - 569(2022) vom: 15. Apr., Seite 37-43 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Puchinger, Kerstin [VerfasserIn] |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Completed 01.04.2022 Date Revised 03.04.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.virol.2022.02.002 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM337768730 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM337768730 | ||
003 | DE-627 | ||
005 | 20231225235149.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.virol.2022.02.002 |2 doi | |
028 | 5 | 2 | |a pubmed24n1125.xml |
035 | |a (DE-627)NLM337768730 | ||
035 | |a (NLM)35245784 | ||
035 | |a (PII)S0042-6822(22)00024-1 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Puchinger, Kerstin |e verfasserin |4 aut | |
245 | 1 | 4 | |a The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 - Results from a prospective cohort of outpatient COVID-19 cases |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 01.04.2022 | ||
500 | |a Date Revised 03.04.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. | ||
520 | |a Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined timepoints for up to one year. RT-PCR and viral culture were performed and seroresponses measured. Participants were classified applying the WHO clinical progression scale. Short symptom to test time (median 5.0 days; p = 0.0016) and high viral loads (VL; median maximum VL: 3∙108 copies/mL; p = 0.0015) were indicative for viral culture positivity. Participants with WHO grade 3 at baseline had significantly higher VLs compared to those with WHO 1 and 2 (p = 0.01). VLs dropped fast within 1 week of symptom onset. Maximum VLs were positively correlated with the magnitude of Ro-N-Ig seroresponse (p = 0.022). Our results describe the dynamics of VLs and antibodies to SARS-CoV-2 in mild to moderate cases that can support public health measures during the ongoing global pandemic | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a Immune response | |
650 | 4 | |a Public health | |
650 | 4 | |a RT-PCR | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a Serological testing | |
650 | 4 | |a Viral culture | |
700 | 1 | |a Castelletti, Noemi |e verfasserin |4 aut | |
700 | 1 | |a Rubio-Acero, Raquel |e verfasserin |4 aut | |
700 | 1 | |a Geldmacher, Christof |e verfasserin |4 aut | |
700 | 1 | |a Eser, Tabea M |e verfasserin |4 aut | |
700 | 1 | |a Deák, Flora |e verfasserin |4 aut | |
700 | 1 | |a Paunovic, Ivana |e verfasserin |4 aut | |
700 | 1 | |a Bakuli, Abhishek |e verfasserin |4 aut | |
700 | 1 | |a Saathoff, Elmar |e verfasserin |4 aut | |
700 | 1 | |a von Meyer, Alexander |e verfasserin |4 aut | |
700 | 1 | |a Markgraf, Alisa |e verfasserin |4 aut | |
700 | 1 | |a Falk, Philine |e verfasserin |4 aut | |
700 | 1 | |a Reich, Jakob |e verfasserin |4 aut | |
700 | 1 | |a Riess, Friedrich |e verfasserin |4 aut | |
700 | 1 | |a Girl, Philipp |e verfasserin |4 aut | |
700 | 1 | |a Müller, Katharina |e verfasserin |4 aut | |
700 | 1 | |a Radon, Katja |e verfasserin |4 aut | |
700 | 1 | |a Guggenbuehl Noller, Jessica Michelle |e verfasserin |4 aut | |
700 | 1 | |a Wölfel, Roman |e verfasserin |4 aut | |
700 | 1 | |a Hoelscher, Michael |e verfasserin |4 aut | |
700 | 1 | |a Kroidl, Inge |e verfasserin |4 aut | |
700 | 1 | |a Wieser, Andreas |e verfasserin |4 aut | |
700 | 1 | |a Olbrich, Laura |e verfasserin |4 aut | |
700 | 0 | |a KoCo19 study group |e verfasserin |4 aut | |
700 | 1 | |a Alamoudi, Emad |e investigator |4 oth | |
700 | 1 | |a Anderson, Jared |e investigator |4 oth | |
700 | 1 | |a Baumann, Maximilian |e investigator |4 oth | |
700 | 1 | |a Behlen, Marieke |e investigator |4 oth | |
700 | 1 | |a Beyerl, Jessica |e investigator |4 oth | |
700 | 1 | |a Böhnlein, Rebecca |e investigator |4 oth | |
700 | 1 | |a Brauer, Anna |e investigator |4 oth | |
700 | 1 | |a Britz, Vera |e investigator |4 oth | |
700 | 1 | |a Bruger, Jan |e investigator |4 oth | |
700 | 1 | |a Caroli, Friedrich |e investigator |4 oth | |
700 | 1 | |a Contento, Lorenzo |e investigator |4 oth | |
700 | 1 | |a Diekmannshemke, Jana |e investigator |4 oth | |
700 | 1 | |a Do, Anna |e investigator |4 oth | |
700 | 1 | |a Dobler, Gerhard |e investigator |4 oth | |
700 | 1 | |a Eberle, Ute |e investigator |4 oth | |
700 | 1 | |a Eckstein, Judith |e investigator |4 oth | |
700 | 1 | |a Frese, Jonathan |e investigator |4 oth | |
700 | 1 | |a Forster, Felix |e investigator |4 oth | |
700 | 1 | |a Frahnow, Turid |e investigator |4 oth | |
700 | 1 | |a Fröschl, Günter |e investigator |4 oth | |
700 | 1 | |a Geisenberger, Otto |e investigator |4 oth | |
700 | 1 | |a Gillig, Kristina |e investigator |4 oth | |
700 | 1 | |a Heiber, Arlett |e investigator |4 oth | |
700 | 1 | |a Hinske, Christian |e investigator |4 oth | |
700 | 1 | |a Hoefflin, Janna |e investigator |4 oth | |
700 | 1 | |a Hofberger, Tim |e investigator |4 oth | |
700 | 1 | |a Höfinger, Michael |e investigator |4 oth | |
700 | 1 | |a Hofmann, Larissa |e investigator |4 oth | |
700 | 1 | |a Horn, Sacha |e investigator |4 oth | |
700 | 1 | |a Huber, Kristina |e investigator |4 oth | |
700 | 1 | |a Janke, Christian |e investigator |4 oth | |
700 | 1 | |a Kappl, Ursula |e investigator |4 oth | |
700 | 1 | |a Kiani, Charlotte |e investigator |4 oth | |
700 | 1 | |a Kroidl, Arne |e investigator |4 oth | |
700 | 1 | |a Laxy, Michael |e investigator |4 oth | |
700 | 1 | |a Leidl, Reiner |e investigator |4 oth | |
700 | 1 | |a Lindner, Felix |e investigator |4 oth | |
700 | 1 | |a Mayrhofer, Rebecca |e investigator |4 oth | |
700 | 1 | |a Mekota, Anna-Maria |e investigator |4 oth | |
700 | 1 | |a Müller, Hannah |e investigator |4 oth | |
700 | 1 | |a Metaxa, Dafni |e investigator |4 oth | |
700 | 1 | |a Pattard, Leonie |e investigator |4 oth | |
700 | 1 | |a Pletschette, Michel |e investigator |4 oth | |
700 | 1 | |a Prückner, Stephan |e investigator |4 oth | |
700 | 1 | |a Pusl, Konstantin |e investigator |4 oth | |
700 | 1 | |a Raimúndez, Elba |e investigator |4 oth | |
700 | 1 | |a Rothe, Camila |e investigator |4 oth | |
700 | 1 | |a Schäfer, Nicole |e investigator |4 oth | |
700 | 1 | |a Schandelmaier, Paul |e investigator |4 oth | |
700 | 1 | |a Schneider, Lara |e investigator |4 oth | |
700 | 1 | |a Schultz, Sophie |e investigator |4 oth | |
700 | 1 | |a Schunk, Mirjam |e investigator |4 oth | |
700 | 1 | |a Schwettmann, Lars |e investigator |4 oth | |
700 | 1 | |a Seibold, Heidi |e investigator |4 oth | |
700 | 1 | |a Sothmann, Peter |e investigator |4 oth | |
700 | 1 | |a Stapor, Paul |e investigator |4 oth | |
700 | 1 | |a Theis, Fabian |e investigator |4 oth | |
700 | 1 | |a Thiel, Verena |e investigator |4 oth | |
700 | 1 | |a Thiesbrummel, Sophie |e investigator |4 oth | |
700 | 1 | |a Thur, Niklas |e investigator |4 oth | |
700 | 1 | |a Waibel, Julia |e investigator |4 oth | |
700 | 1 | |a Wallrauch, Claudia |e investigator |4 oth | |
700 | 1 | |a Winter, Simon |e investigator |4 oth | |
700 | 1 | |a Wolff, Julia |e investigator |4 oth | |
700 | 1 | |a Wullinger, Pia |e investigator |4 oth | |
700 | 1 | |a Yaqine, Houda |e investigator |4 oth | |
700 | 1 | |a Zange, Sabine |e investigator |4 oth | |
700 | 1 | |a Zeggini, Eleftheria |e investigator |4 oth | |
700 | 1 | |a Zimmermann, Thomas |e investigator |4 oth | |
700 | 1 | |a Zielke, Anna |e investigator |4 oth | |
700 | 1 | |a Ibraheem, Mohamed |e investigator |4 oth | |
700 | 1 | |a Ahmed, Mohamed |e investigator |4 oth | |
700 | 1 | |a Becker, Marc |e investigator |4 oth | |
700 | 1 | |a Diepers, Paulina |e investigator |4 oth | |
700 | 1 | |a Schälte, Yannik |e investigator |4 oth | |
700 | 1 | |a Garí, Mercè |e investigator |4 oth | |
700 | 1 | |a Pütz, Peter |e investigator |4 oth | |
700 | 1 | |a Pritsch, Michael |e investigator |4 oth | |
700 | 1 | |a Fingerle, Volker |e investigator |4 oth | |
700 | 1 | |a Le Gleut, Ronan |e investigator |4 oth | |
700 | 1 | |a Gilberg, Leonard |e investigator |4 oth | |
700 | 1 | |a Brand, Isabel |e investigator |4 oth | |
700 | 1 | |a Diefenbach, Max |e investigator |4 oth | |
700 | 1 | |a Eser, Tabea |e investigator |4 oth | |
700 | 1 | |a Weinauer, Franz |e investigator |4 oth | |
700 | 1 | |a Martin, Silke |e investigator |4 oth | |
700 | 1 | |a Quenzel, Ernst-Markus |e investigator |4 oth | |
700 | 1 | |a Durner, Jürgen |e investigator |4 oth | |
700 | 1 | |a Girl, Philipp |e investigator |4 oth | |
700 | 1 | |a Müller, Katharina |e investigator |4 oth | |
700 | 1 | |a Radon, Katja |e investigator |4 oth | |
700 | 1 | |a Fuchs, Christiane |e investigator |4 oth | |
700 | 1 | |a Hasenauer, Jan |e investigator |4 oth | |
773 | 0 | 8 | |i Enthalten in |t Virology |d 1955 |g 569(2022) vom: 15. Apr., Seite 37-43 |w (DE-627)NLM000011347 |x 1096-0341 |7 nnns |
773 | 1 | 8 | |g volume:569 |g year:2022 |g day:15 |g month:04 |g pages:37-43 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.virol.2022.02.002 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 569 |j 2022 |b 15 |c 04 |h 37-43 |