Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers : a study by the Italian DLB study group (DLB-SINdem)
© 2022. The Author(s)..
INTRODUCTION: Dementia with Lewy bodies (DLB) may represent a diagnostic challenge, since its clinical picture overlaps with other dementia. Two toolkits have been developed to aid the clinician to diagnose DLB: the Lewy Body Composite Risk Score (LBCRS) and the Assessment Toolkit for DLB (AT-DLB). We aim to evaluate the reliability of these two questionnaires, and their ability to enhance the interpretation of the international consensus diagnostic criteria.
METHODS: LBCRS and AT-DLB were distributed to 135 Italian Neurological Centers for Cognitive Decline and Dementia (CDCDs), with the indication to administer them to all patients with dementia referred within the subsequent 3 months. We asked to subsequently apply consensus criteria for DLB diagnosis, to validate the diagnostic accuracy of the two toolkits.
RESULTS: A total of 23 Centers joined the study; 1854 patients were enrolled. We found a prevalence of possible or probable DLB of 13% each (26% total), according to the consensus criteria. LBCRS toolkit showed good reliability, with a Cronbach alpha of 0.77, stable even after removing variables from the construct. AT-DLB toolkit Cronbach alpha was 0.52 and, after the subtraction of the "cognitive fluctuation" criterion, was only 0.31. Accuracy, sensitivity, and specificity were higher for LBCRS vs. AT-DLB. However, when simultaneously considered in the logistic models, AT-DLB showed a better performance (p < 0.001). Overall, the concordance between LBCRS positive and AT-DLB possible/probable was of 78.02% CONCLUSIONS: In a clinical setting, the LBCRS and AT-DLB questionnaires have good accuracy for DLB diagnosis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
|---|---|
| Enthalten in: |
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 43(2022), 7 vom: 04. Juli, Seite 4221-4229 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
Clinical diagnosis |
|---|
| Anmerkungen: |
Date Completed 23.06.2022 Date Revised 19.07.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s10072-022-05987-z |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM337759383 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM337759383 | ||
| 003 | DE-627 | ||
| 005 | 20231225235137.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10072-022-05987-z |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1125.xml |
| 035 | |a (DE-627)NLM337759383 | ||
| 035 | |a (NLM)35244829 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Russo, Mirella |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers |b a study by the Italian DLB study group (DLB-SINdem) |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.06.2022 | ||
| 500 | |a Date Revised 19.07.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a INTRODUCTION: Dementia with Lewy bodies (DLB) may represent a diagnostic challenge, since its clinical picture overlaps with other dementia. Two toolkits have been developed to aid the clinician to diagnose DLB: the Lewy Body Composite Risk Score (LBCRS) and the Assessment Toolkit for DLB (AT-DLB). We aim to evaluate the reliability of these two questionnaires, and their ability to enhance the interpretation of the international consensus diagnostic criteria | ||
| 520 | |a METHODS: LBCRS and AT-DLB were distributed to 135 Italian Neurological Centers for Cognitive Decline and Dementia (CDCDs), with the indication to administer them to all patients with dementia referred within the subsequent 3 months. We asked to subsequently apply consensus criteria for DLB diagnosis, to validate the diagnostic accuracy of the two toolkits | ||
| 520 | |a RESULTS: A total of 23 Centers joined the study; 1854 patients were enrolled. We found a prevalence of possible or probable DLB of 13% each (26% total), according to the consensus criteria. LBCRS toolkit showed good reliability, with a Cronbach alpha of 0.77, stable even after removing variables from the construct. AT-DLB toolkit Cronbach alpha was 0.52 and, after the subtraction of the "cognitive fluctuation" criterion, was only 0.31. Accuracy, sensitivity, and specificity were higher for LBCRS vs. AT-DLB. However, when simultaneously considered in the logistic models, AT-DLB showed a better performance (p < 0.001). Overall, the concordance between LBCRS positive and AT-DLB possible/probable was of 78.02% CONCLUSIONS: In a clinical setting, the LBCRS and AT-DLB questionnaires have good accuracy for DLB diagnosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Clinical diagnosis | |
| 650 | 4 | |a Cognitive impairment | |
| 650 | 4 | |a Consensus criteria | |
| 650 | 4 | |a Dementia | |
| 650 | 4 | |a Dementia with Lewy bodies | |
| 650 | 4 | |a Diagnostic accuracy | |
| 650 | 4 | |a Diagnostic toolkits | |
| 700 | 1 | |a Carrarini, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Di Iorio, Angelo |e verfasserin |4 aut | |
| 700 | 1 | |a Pellegrino, Raffaello |e verfasserin |4 aut | |
| 700 | 1 | |a Bruni, Amalia Cecilia |e verfasserin |4 aut | |
| 700 | 1 | |a Caratozzolo, Salvatore |e verfasserin |4 aut | |
| 700 | 1 | |a Chiari, Annalisa |e verfasserin |4 aut | |
| 700 | 1 | |a Pretta, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Marra, Camillo |e verfasserin |4 aut | |
| 700 | 1 | |a Cotelli, Maria Sofia |e verfasserin |4 aut | |
| 700 | 1 | |a Arighi, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Fumagalli, Giorgio G |e verfasserin |4 aut | |
| 700 | 1 | |a Cataruzza, Tatiana |e verfasserin |4 aut | |
| 700 | 1 | |a Caso, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Paci, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Rosso, Mara |e verfasserin |4 aut | |
| 700 | 1 | |a Amici, Serena |e verfasserin |4 aut | |
| 700 | 1 | |a Giannandrea, David |e verfasserin |4 aut | |
| 700 | 1 | |a Pilotto, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Luzzi, Simona |e verfasserin |4 aut | |
| 700 | 1 | |a Castellano, Annalisa |e verfasserin |4 aut | |
| 700 | 1 | |a D'antonio, Fabrizia |e verfasserin |4 aut | |
| 700 | 1 | |a Luca, Antonina |e verfasserin |4 aut | |
| 700 | 1 | |a Gelosa, Giorgio |e verfasserin |4 aut | |
| 700 | 1 | |a Piccoli, Tommaso |e verfasserin |4 aut | |
| 700 | 1 | |a Mauri, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Agosta, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Babiloni, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Borroni, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Bozzali, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Filippi, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Galimberti, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Monastero, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Muscio, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Parnetti, Lucilla |e verfasserin |4 aut | |
| 700 | 1 | |a Perani, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Serra, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Silani, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Tiraboschi, Pietro |e verfasserin |4 aut | |
| 700 | 1 | |a Cagnin, Annachiara |e verfasserin |4 aut | |
| 700 | 1 | |a Padovani, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Bonanni, Laura |e verfasserin |4 aut | |
| 700 | 0 | |a Italian Dementia with Lewy bodies Study Group (DLB-SINdem) |e verfasserin |4 aut | |
| 700 | 1 | |a Roberta, Baschi |e investigator |4 oth | |
| 700 | 1 | |a Federica, Fragiacomo |e investigator |4 oth | |
| 700 | 1 | |a Sebastiano, Galantucci |e investigator |4 oth | |
| 700 | 1 | |a Caterina, Gaspari |e investigator |4 oth | |
| 700 | 1 | |a Gianmarco, Gazzola |e investigator |4 oth | |
| 700 | 1 | |a Giuseppe, Magnani |e investigator |4 oth | |
| 700 | 1 | |a Giulia, Mazzon |e investigator |4 oth | |
| 700 | 1 | |a Stefano, Mozzetta |e investigator |4 oth | |
| 700 | 1 | |a Carmela, Ravanelli |e investigator |4 oth | |
| 700 | 1 | |a Marco, Ruggiero |e investigator |4 oth | |
| 700 | 1 | |a Pierpaolo, Salute |e investigator |4 oth | |
| 700 | 1 | |a Giuseppe, Scamarcia Pietro |e investigator |4 oth | |
| 700 | 1 | |a Marinella, Turla |e investigator |4 oth | |
| 700 | 1 | |a Federico, Verde |e investigator |4 oth | |
| 700 | 1 | |a Antonietta, Volontè Maria |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology |d 2000 |g 43(2022), 7 vom: 04. Juli, Seite 4221-4229 |w (DE-627)NLM108608468 |x 1590-3478 |7 nnns |
| 773 | 1 | 8 | |g volume:43 |g year:2022 |g number:7 |g day:04 |g month:07 |g pages:4221-4229 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10072-022-05987-z |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 43 |j 2022 |e 7 |b 04 |c 07 |h 4221-4229 | ||