Predicting eating disorder and anxiety symptoms using disorder-specific and transdiagnostic polygenic scores for anorexia nervosa and obsessive-compulsive disorder
BACKGROUND: Clinical, epidemiological, and genetic findings support an overlap between eating disorders, obsessive-compulsive disorder (OCD), and anxiety symptoms. However, little research has examined the role of genetics in the expression of underlying phenotypes. We investigated whether the anorexia nervosa (AN), OCD, or AN/OCD transdiagnostic polygenic scores (PGS) predict eating disorder, OCD, and anxiety symptoms in a large developmental cohort in a sex-specific manner.
METHODS: Using summary statistics from Psychiatric Genomics Consortium AN and OCD genome-wide association studies, we conducted an AN/OCD transdiagnostic genome-wide association meta-analysis. We then calculated AN, OCD, and AN/OCD PGS in participants from the Avon Longitudinal Study of Parents and Children to predict eating disorder, OCD, and anxiety symptoms, stratified by sex (combined N = 3212-5369 per phenotype).
RESULTS: The PGS prediction of eating disorder, OCD, and anxiety phenotypes differed between sexes, although effect sizes were small. AN and AN/OCD PGS played a more prominent role in predicting eating disorder and anxiety risk than OCD PGS, especially in girls. AN/OCD PGS provided a small boost over AN PGS in the prediction of some anxiety symptoms. All three PGS predicted higher compulsive exercise across different developmental timepoints [β = 0.03 (s.e. = 0.01) for AN and AN/OCD PGS at age 14; β = 0.05 (s.e. = 0.02) for OCD PGS at age 16] in girls.
CONCLUSIONS: Compulsive exercise may have a transdiagnostic genetic etiology, and AN genetic risk may play a role in the presence of anxiety symptoms. Converging with prior twin literature, our results also suggest that some of the contribution of genetic risk may be sex-specific.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Psychological medicine - 53(2023), 7 vom: 01. Mai, Seite 3021-3035 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yilmaz, Zeynep [VerfasserIn] |
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| Links: |
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| Themen: |
Anxiety |
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| Anmerkungen: |
Date Completed 17.07.2023 Date Revised 26.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1017/S0033291721005079 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337751684 |
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| 100 | 1 | |a Yilmaz, Zeynep |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Predicting eating disorder and anxiety symptoms using disorder-specific and transdiagnostic polygenic scores for anorexia nervosa and obsessive-compulsive disorder |
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| 500 | |a Date Completed 17.07.2023 | ||
| 500 | |a Date Revised 26.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Clinical, epidemiological, and genetic findings support an overlap between eating disorders, obsessive-compulsive disorder (OCD), and anxiety symptoms. However, little research has examined the role of genetics in the expression of underlying phenotypes. We investigated whether the anorexia nervosa (AN), OCD, or AN/OCD transdiagnostic polygenic scores (PGS) predict eating disorder, OCD, and anxiety symptoms in a large developmental cohort in a sex-specific manner | ||
| 520 | |a METHODS: Using summary statistics from Psychiatric Genomics Consortium AN and OCD genome-wide association studies, we conducted an AN/OCD transdiagnostic genome-wide association meta-analysis. We then calculated AN, OCD, and AN/OCD PGS in participants from the Avon Longitudinal Study of Parents and Children to predict eating disorder, OCD, and anxiety symptoms, stratified by sex (combined N = 3212-5369 per phenotype) | ||
| 520 | |a RESULTS: The PGS prediction of eating disorder, OCD, and anxiety phenotypes differed between sexes, although effect sizes were small. AN and AN/OCD PGS played a more prominent role in predicting eating disorder and anxiety risk than OCD PGS, especially in girls. AN/OCD PGS provided a small boost over AN PGS in the prediction of some anxiety symptoms. All three PGS predicted higher compulsive exercise across different developmental timepoints [β = 0.03 (s.e. = 0.01) for AN and AN/OCD PGS at age 14; β = 0.05 (s.e. = 0.02) for OCD PGS at age 16] in girls | ||
| 520 | |a CONCLUSIONS: Compulsive exercise may have a transdiagnostic genetic etiology, and AN genetic risk may play a role in the presence of anxiety symptoms. Converging with prior twin literature, our results also suggest that some of the contribution of genetic risk may be sex-specific | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Eating disorders | |
| 650 | 4 | |a anxiety | |
| 650 | 4 | |a developmental cohort | |
| 650 | 4 | |a obsesive-compulsive disorder | |
| 650 | 4 | |a polygenic scores | |
| 700 | 1 | |a Schaumberg, Katherine |e verfasserin |4 aut | |
| 700 | 1 | |a Halvorsen, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Goodman, Erica L |e verfasserin |4 aut | |
| 700 | 1 | |a Brosof, Leigh C |e verfasserin |4 aut | |
| 700 | 1 | |a Crowley, James J |e verfasserin |4 aut | |
| 700 | 0 | |a Anorexia Nervosa Genetics Initiative |e verfasserin |4 aut | |
| 700 | 0 | |a Eating Disorders Working Group of the Psychiatric Genomics Consortium |e verfasserin |4 aut | |
| 700 | 0 | |a Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium |e verfasserin |4 aut | |
| 700 | 1 | |a Mathews, Carol A |e verfasserin |4 aut | |
| 700 | 1 | |a Mattheisen, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Breen, Gerome |e verfasserin |4 aut | |
| 700 | 1 | |a Bulik, Cynthia M |e verfasserin |4 aut | |
| 700 | 1 | |a Micali, Nadia |e verfasserin |4 aut | |
| 700 | 1 | |a Zerwas, Stephanie C |e verfasserin |4 aut | |
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