The ISAQ Score Does Not Predict Adrenal Crisis in Patients with Primary Adrenal Insufficiency
Thieme. All rights reserved..
OBJECTIVE: This study aimed to investigate the ability of the immune system assessment questionnaire (ISAQ) to predict adrenal crisis (AC) and infectious events in patients with primary adrenal insufficiency (PAI).
DESIGN: This was a prospective single-centre study over three years.
METHODS: Patients answered the ISAQ at baseline and were seen every 4-6 months in the endocrine outpatient clinic. At each visit previous infectious periods which required an increase in daily glucocorticoid dosage and AC were reported and documented. Seventy-five patients with PAI (53 women; 43 patients with autoimmune PAI, 20 patients with salt-wasting congenital adrenal hyperplasia and 12 patients who underwent bilateral adrenalectomy) were analysed. Due to the COVID-19 pandemic and consecutive lockdown measures, the data were analysed separately for March 2018 to March 2020 (period 1), and March 2020 to March 2021 (period 2).
RESULTS: During period 1 the ISAQ score significantly correlated with the number of reported infectious events (r=0.351; p<0.01), but not during period 2 (r=0.059, p=0.613), in which the number of infectious events per patient-year significantly decreased (1.1±0.1 vs 0.4±0.1; p<0.001). The frequency of AC decreased from 8.8 to 2.4 per 100 patient-years between the two study periods. The ISAQ score was not different between patients with or without AC.
CONCLUSIONS: The ISAQ score does not identify patients prone to ACs. The COVID-19 pandemic and consecutive lockdown measures significantly diminished the frequency of infectious events and ACs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 |
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| Enthalten in: |
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 130(2022), 8 vom: 29. Aug., Seite 554-560 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Quinkler, Marcus [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 15.08.2022 Date Revised 15.08.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1055/a-1734-2466 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337719012 |
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| 245 | 1 | 4 | |a The ISAQ Score Does Not Predict Adrenal Crisis in Patients with Primary Adrenal Insufficiency |
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| 500 | |a Date Revised 15.08.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Thieme. All rights reserved. | ||
| 520 | |a OBJECTIVE: This study aimed to investigate the ability of the immune system assessment questionnaire (ISAQ) to predict adrenal crisis (AC) and infectious events in patients with primary adrenal insufficiency (PAI) | ||
| 520 | |a DESIGN: This was a prospective single-centre study over three years | ||
| 520 | |a METHODS: Patients answered the ISAQ at baseline and were seen every 4-6 months in the endocrine outpatient clinic. At each visit previous infectious periods which required an increase in daily glucocorticoid dosage and AC were reported and documented. Seventy-five patients with PAI (53 women; 43 patients with autoimmune PAI, 20 patients with salt-wasting congenital adrenal hyperplasia and 12 patients who underwent bilateral adrenalectomy) were analysed. Due to the COVID-19 pandemic and consecutive lockdown measures, the data were analysed separately for March 2018 to March 2020 (period 1), and March 2020 to March 2021 (period 2) | ||
| 520 | |a RESULTS: During period 1 the ISAQ score significantly correlated with the number of reported infectious events (r=0.351; p<0.01), but not during period 2 (r=0.059, p=0.613), in which the number of infectious events per patient-year significantly decreased (1.1±0.1 vs 0.4±0.1; p<0.001). The frequency of AC decreased from 8.8 to 2.4 per 100 patient-years between the two study periods. The ISAQ score was not different between patients with or without AC | ||
| 520 | |a CONCLUSIONS: The ISAQ score does not identify patients prone to ACs. The COVID-19 pandemic and consecutive lockdown measures significantly diminished the frequency of infectious events and ACs | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Kienitz, Tina |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association |d 1996 |g 130(2022), 8 vom: 29. Aug., Seite 554-560 |w (DE-627)NLM075292904 |x 1439-3646 |7 nnns |
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