Human defensin-inspired discovery of peptidomimetic antibiotics
SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:119 |
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| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 119(2022), 10 vom: 08. März, Seite e2117283119 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Luo, Gan [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 21.03.2022 Date Revised 02.09.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1073/pnas.2117283119 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 700 | 1 | |a Cheng, BaoLi |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, ZhiPeng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, WuYuan |e verfasserin |4 aut | |
| 700 | 1 | |a Nemeth, Elizabeta |e verfasserin |4 aut | |
| 700 | 1 | |a Ganz, Tomas |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, XiangMing |e verfasserin |4 aut | |
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