Taiwan's Response to Influenza : A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness
Copyright © 2022. Published by Elsevier Ltd..
OBJECTIVES: To evaluate class suspension and mass vaccination implemented among Taipei schoolchildren during the 2009 influenza pandemic and investigate factors affecting antibody responses.
METHODS: We conducted 2 cohort studies on: (1) 972 schoolchildren from November 2009-March 2010 to evaluate pandemic policies and (2) 935 schoolchildren from November 2011-March 2012 to verify factors in antibody waning. Anti-influenza H1N1pdm09 hemagglutination inhibition antibodies (HI-Ab) were measured from serum samples collected before vaccination, and at 1 and 4 months after vaccination. Factors affecting HI-Ab responses were investigated through logistic regression and generalized estimating equation.
RESULTS: Seroprevalence of H1N1pdm09 before vaccination was significantly higher among schoolchildren who experienced class suspensions than those who did not (59.6% vs 47.5%, p<0.05). Participating in after-school activities (adjusted odds ratio [aOR]=2.47, p=0.047) and having ≥3 hours per week of exercise (aOR=2.86, p=0.019) were significantly correlated with H1N1pdm09 infection. Two doses of the H1N1pdm09 vaccine demonstrated significantly better antibody persistence than 1 dose (HI-Ab geometric mean titer: 132.5 vs 88.6, p=0.047). Vaccine effectiveness after controlling for preexisting immunity was 86% (32%-97%). Exercise ≥3 hours per week and preexisting immunity were significantly associated with antibody waning/maintenance.
CONCLUSIONS: This study is the first to show that exercise and preexisting immunity may affect antibody waning. Further investigation is needed to identify immune correlates of protection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:121 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 121(2022) vom: 01. Aug., Seite 226-237 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ho, Pui-I [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Viral |
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| Anmerkungen: |
Date Completed 14.06.2022 Date Revised 14.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2022.02.038 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337670773 |
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| 245 | 1 | 0 | |a Taiwan's Response to Influenza |b A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness |
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| 500 | |a Date Revised 14.06.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022. Published by Elsevier Ltd. | ||
| 520 | |a OBJECTIVES: To evaluate class suspension and mass vaccination implemented among Taipei schoolchildren during the 2009 influenza pandemic and investigate factors affecting antibody responses | ||
| 520 | |a METHODS: We conducted 2 cohort studies on: (1) 972 schoolchildren from November 2009-March 2010 to evaluate pandemic policies and (2) 935 schoolchildren from November 2011-March 2012 to verify factors in antibody waning. Anti-influenza H1N1pdm09 hemagglutination inhibition antibodies (HI-Ab) were measured from serum samples collected before vaccination, and at 1 and 4 months after vaccination. Factors affecting HI-Ab responses were investigated through logistic regression and generalized estimating equation | ||
| 520 | |a RESULTS: Seroprevalence of H1N1pdm09 before vaccination was significantly higher among schoolchildren who experienced class suspensions than those who did not (59.6% vs 47.5%, p<0.05). Participating in after-school activities (adjusted odds ratio [aOR]=2.47, p=0.047) and having ≥3 hours per week of exercise (aOR=2.86, p=0.019) were significantly correlated with H1N1pdm09 infection. Two doses of the H1N1pdm09 vaccine demonstrated significantly better antibody persistence than 1 dose (HI-Ab geometric mean titer: 132.5 vs 88.6, p=0.047). Vaccine effectiveness after controlling for preexisting immunity was 86% (32%-97%). Exercise ≥3 hours per week and preexisting immunity were significantly associated with antibody waning/maintenance | ||
| 520 | |a CONCLUSIONS: This study is the first to show that exercise and preexisting immunity may affect antibody waning. Further investigation is needed to identify immune correlates of protection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Taiwan | |
| 650 | 4 | |a emerging infectious diseases | |
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| 650 | 7 | |a Influenza Vaccines |2 NLM | |
| 700 | 1 | |a Liu, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Tiger Zheng-Rong |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Ta-Chien |e verfasserin |4 aut | |
| 700 | 1 | |a Ku, Chia-Chi |e verfasserin |4 aut | |
| 700 | 1 | |a Lien, Yu-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Yea-Huei Daphne |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Juine-Ruey |e verfasserin |4 aut | |
| 700 | 1 | |a Yen, Muh-Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Tu, Yu-Kang |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Wan-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Compans, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Ping-Ing |e verfasserin |4 aut | |
| 700 | 1 | |a King, Chwan-Chuen |e verfasserin |4 aut | |
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