Melding Synthetic Molecules and Genetically Encoded Proteins to Forge New Tools for Neuroscience
Unraveling the complexity of the brain requires sophisticated methods to probe and perturb neurobiological processes with high spatiotemporal control. The field of chemical biology has produced general strategies to combine the molecular specificity of small-molecule tools with the cellular specificity of genetically encoded reagents. Here, we survey the application, refinement, and extension of these hybrid small-molecule:protein methods to problems in neuroscience, which yields powerful reagents to precisely measure and manipulate neural systems.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Annual review of neuroscience - 45(2022) vom: 08. Juli, Seite 131-150 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kumar, Pratik [VerfasserIn] |
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| Links: |
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| Themen: |
Cell-specific pharmacology |
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| Anmerkungen: |
Date Completed 12.07.2022 Date Revised 13.07.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1146/annurev-neuro-110520-030031 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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