Nanocellulose-Based Biomedical Scaffolds in Future Bioeconomy : A Techno-Legal Assessment of the State-of-the-Art

Copyright © 2022 Mishra, Pavelek, Rasticova, Mishra and Ekielski..

Nanocellulose is a broader term used for nano-scaled cellulosic crystal and/or fibrils of plant or animal origin. Where bacterial nanocellulose was immediately accepted in biomedicine due to its "cleaner" nature, the plant-based nanocellulose has seen several roadblocks. This manuscript assesses the technological aspects (chemistry of cellulose, nanocellulose producing methods, its purity, and biological properties including toxicity and suggested applications in final drug formulation) along with legal aspects in REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) regulation by the European Union, EMA (European Medicine Agency). The botanical biomass processing methods leading to the nanoscale impurity (lignin and others) on nanocellulose surface, along with surface modification with harsh acid treatments are found to be two major sources of "impurity" in botanical biomass derived nanocellulose. The status of nanocellulose under the light of REACH regulation along with EMA has been covered. The provided information can be directly used by material and biomedical scientists while developing new nanocellulose production strategies as well as formulation design for European markets.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:9

Enthalten in:

Frontiers in bioengineering and biotechnology - 9(2021) vom: 01., Seite 789603

Sprache:

Englisch

Beteiligte Personen:

Mishra, Pawan Kumar [VerfasserIn]
Pavelek, Ondrej [VerfasserIn]
Rasticova, Martina [VerfasserIn]
Mishra, Harshita [VerfasserIn]
Ekielski, Adam [VerfasserIn]

Links:

Volltext

Themen:

Bioeconomy
Biomedicine
Cellulose
EMA
Journal Article
Nanocellulose
REACh regulation
Review

Anmerkungen:

Date Revised 01.03.2022

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.3389/fbioe.2021.789603

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM337552762