Establishment of Reference Intervals for Thyroid-Associated Hormones Using refineR Algorithm in Chinese Population at High-Altitude Areas
Copyright © 2022 Ma, Zhong, Zou, Liu, Li, Pang, Liu, Zejipuchi, Tian, Hou, Wang, Cheng and Qiu..
Objectives: Diagnosis of thyroid disease among individuals dwelling at high altitude remains a challenge. Reference intervals (RIs) for thyroid-associated hormones among Tibetans living at various high altitudes were established to improve diagnosis.
Methods: One thousand two hundred eighty-one subjects were randomly recruited from Nyingchi, Shigatse/Lhasa, and Ali of Tibet. Thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were measured by the Cobas e601 electrochemiluminescence analyzer. We used multiple linear regression and variance component analysis to assess the effect of sex, age, and altitude on hormones. RIs were established by refineR algorithm and compared with those provided by the manufacturer.
Results: Serum TSH was significantly lower in males than in females, while FT3 and FT4 were higher in males. Both FT3 and FT4 decreased with increasing age. FT3 increased with altitude, while TSH and FT4 were less influenced by altitude. The RI for TSH was 0.764-5.784 μIU/ml, while for FT4, the RIs were 12.36-19.38 pmol/L in females and 14.84-20.18 pmol/L in males. The RIs for FT3 at Nyingchi, Shigatse/Lhasa, and Ali in females were 4.09-4.98, 4.31-5.45, and 4.82-5.58 pmol/L, while in males, the values were 4.82-5.41, 4.88-5.95, and 5.26-6.06 pmol/L, respectively. The obtained RIs for TSH and FT4 were generally higher, while that for FT3 was narrower than the RIs provided by Cobas.
Conclusions: Specific RIs were established for thyroid-associated hormones among Tibetans, which were significantly different from those provided by the manufacturer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Frontiers in endocrinology - 13(2022) vom: 01., Seite 816970 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ma, Chaochao [VerfasserIn] |
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| Links: |
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| Themen: |
High altitude |
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| Anmerkungen: |
Date Completed 31.03.2022 Date Revised 01.04.2022 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fendo.2022.816970 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM337537429 |
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| 100 | 1 | |a Ma, Chaochao |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Establishment of Reference Intervals for Thyroid-Associated Hormones Using refineR Algorithm in Chinese Population at High-Altitude Areas |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 31.03.2022 | ||
| 500 | |a Date Revised 01.04.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Ma, Zhong, Zou, Liu, Li, Pang, Liu, Zejipuchi, Tian, Hou, Wang, Cheng and Qiu. | ||
| 520 | |a Objectives: Diagnosis of thyroid disease among individuals dwelling at high altitude remains a challenge. Reference intervals (RIs) for thyroid-associated hormones among Tibetans living at various high altitudes were established to improve diagnosis | ||
| 520 | |a Methods: One thousand two hundred eighty-one subjects were randomly recruited from Nyingchi, Shigatse/Lhasa, and Ali of Tibet. Thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were measured by the Cobas e601 electrochemiluminescence analyzer. We used multiple linear regression and variance component analysis to assess the effect of sex, age, and altitude on hormones. RIs were established by refineR algorithm and compared with those provided by the manufacturer | ||
| 520 | |a Results: Serum TSH was significantly lower in males than in females, while FT3 and FT4 were higher in males. Both FT3 and FT4 decreased with increasing age. FT3 increased with altitude, while TSH and FT4 were less influenced by altitude. The RI for TSH was 0.764-5.784 μIU/ml, while for FT4, the RIs were 12.36-19.38 pmol/L in females and 14.84-20.18 pmol/L in males. The RIs for FT3 at Nyingchi, Shigatse/Lhasa, and Ali in females were 4.09-4.98, 4.31-5.45, and 4.82-5.58 pmol/L, while in males, the values were 4.82-5.41, 4.88-5.95, and 5.26-6.06 pmol/L, respectively. The obtained RIs for TSH and FT4 were generally higher, while that for FT3 was narrower than the RIs provided by Cobas | ||
| 520 | |a Conclusions: Specific RIs were established for thyroid-associated hormones among Tibetans, which were significantly different from those provided by the manufacturer | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a high altitude | |
| 650 | 4 | |a reference interval | |
| 650 | 4 | |a refineR algorithm | |
| 650 | 4 | |a thyroid hormones | |
| 650 | 4 | |a thyrotropin | |
| 650 | 7 | |a Thyroxine |2 NLM | |
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| 700 | 1 | |a Zhong, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Zou, Yutong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zhijuan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Honglei |e verfasserin |4 aut | |
| 700 | 1 | |a Pang, Jinrong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiaoxing |e verfasserin |4 aut | |
| 700 | 1 | |a Zejipuchi |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Liping |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Li'an |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Danchen |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Xinqi |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Ling |e verfasserin |4 aut | |
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