Gut microbiota from Mexican patients with metabolic syndrome and HIV infection : An inflammatory profile
© 2022 Society for Applied Microbiology..
AIM: A remarkable increase in metabolic syndrome (MetS) has occurred in HIV-infected subjects. Gut dysbiosis is involved in the pathogenesis of metabolic disorders. Therefore, the aim is to explore the profile of the gut microbiota in Mexican population with HIV infection and MetS.
METHODS AND RESULTS: In all, 30 HIV-infected patients with MetS were compared to a group of 30 patients without MetS, treated with integrase inhibitors and undetectable viral load were included in the study. Stool samples were analysed by 16S rRNA next-generation sequencing. High-sensitivity C-reactive protein >3 mg L-1 and higher scores in cardiometabolic indices were associated with MetS. The group with MetS was characterized by a decrease in α-diversity, higher abundance of Enterobacteriaceae and Prevotella, as well as a dramatic decrease in bacteria producing short-chain fatty acids. Prevotella negatively correlated with Akkermansia, Lactobacillus and Anaerostipes. Interestingly, the group without MetS presented higher abundance of Faecalibacterium, Ruminococcus, Anaerofilum, Oscillospira and Anaerostipes. Functional pathways related to energy metabolism and inflammation were increased in the group with MetS.
CONCLUSIONS: HIV-infected patients with MetS present a strong inflammatory microbiota profile; therefore, future strategies to balance intestinal dysbiosis should be implemented.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:132 |
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| Enthalten in: |
Journal of applied microbiology - 132(2022), 5 vom: 15. Mai, Seite 3839-3852 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Amador-Lara, Fernando [VerfasserIn] |
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| Links: |
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| Themen: |
Disease processes |
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| Anmerkungen: |
Date Completed 15.04.2022 Date Revised 15.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/jam.15505 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337500703 |
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| 245 | 1 | 0 | |a Gut microbiota from Mexican patients with metabolic syndrome and HIV infection |b An inflammatory profile |
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| 500 | |a Date Revised 15.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 Society for Applied Microbiology. | ||
| 520 | |a AIM: A remarkable increase in metabolic syndrome (MetS) has occurred in HIV-infected subjects. Gut dysbiosis is involved in the pathogenesis of metabolic disorders. Therefore, the aim is to explore the profile of the gut microbiota in Mexican population with HIV infection and MetS | ||
| 520 | |a METHODS AND RESULTS: In all, 30 HIV-infected patients with MetS were compared to a group of 30 patients without MetS, treated with integrase inhibitors and undetectable viral load were included in the study. Stool samples were analysed by 16S rRNA next-generation sequencing. High-sensitivity C-reactive protein >3 mg L-1 and higher scores in cardiometabolic indices were associated with MetS. The group with MetS was characterized by a decrease in α-diversity, higher abundance of Enterobacteriaceae and Prevotella, as well as a dramatic decrease in bacteria producing short-chain fatty acids. Prevotella negatively correlated with Akkermansia, Lactobacillus and Anaerostipes. Interestingly, the group without MetS presented higher abundance of Faecalibacterium, Ruminococcus, Anaerofilum, Oscillospira and Anaerostipes. Functional pathways related to energy metabolism and inflammation were increased in the group with MetS | ||
| 520 | |a CONCLUSIONS: HIV-infected patients with MetS present a strong inflammatory microbiota profile; therefore, future strategies to balance intestinal dysbiosis should be implemented | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a disease processes | |
| 650 | 4 | |a infection | |
| 650 | 4 | |a intestinal microbiology | |
| 650 | 4 | |a metabolic processes | |
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| 700 | 1 | |a Peña-Rodríguez, Marcela |e verfasserin |4 aut | |
| 700 | 1 | |a Alvarez-Zavala, Monserrat |e verfasserin |4 aut | |
| 700 | 1 | |a Sanchez-Reyes, Karina |e verfasserin |4 aut | |
| 700 | 1 | |a Toscano-Piña, Marcela |e verfasserin |4 aut | |
| 700 | 1 | |a Peregrina-Lucano, Alejandro A |e verfasserin |4 aut | |
| 700 | 1 | |a Del Toro-Arreola, Susana |e verfasserin |4 aut | |
| 700 | 1 | |a González-Hernández, Luz A |e verfasserin |4 aut | |
| 700 | 1 | |a Bueno-Topete, Miriam R |e verfasserin |4 aut | |
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