Neutrophil to lymphocyte ratio is a transdiagnostic biomarker of depression and structural and functional brain alterations in older adults
Copyright © 2022 Elsevier B.V. All rights reserved..
The neutrophil to lymphocyte ratio (N:L) is an emergent transdiagnostic biomarker shown to predict peripheral inflammation as well as neuropsychiatric impairment. The afferent signaling of inflammation to the central nervous system has been implicated in the pathophysiology of sickness behavior and depression. Here, the N:L was compared to structural and functional limbic alterations found concomitant with depression within a geriatric cohort. Venous blood was collected for a complete blood count, and magnetic resonance imaging as well as phenotypic data were collected from the 66 community-dwelling older adults (aged 65-86 years). The N:L was regressed on gray matter volume and resting-state functional connectivity (rsFC) of the subgenual anterior cingulate (sgACC). Thresholded parameter estimates were extracted from structural and functional brain scans and bivariate associations tested with scores on the geriatric depression scale. Greater N:L predicted lower volume of hypothalamus and rsFC of sgACC with ventromedial prefrontal cortex. Both parameters were correlated (p < 0.05) with greater symptomology in those reporting moderate to severe levels of depression. These findings support the N:L as a transdiagnostic biomarker of limbic alteration underpinning mood disturbance in non-treated older adults.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:365 |
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| Enthalten in: |
Journal of neuroimmunology - 365(2022) vom: 15. Apr., Seite 577831 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
McIntosh, Roger C [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 27.04.2022 Date Revised 27.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jneuroim.2022.577831 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337488738 |
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| 100 | 1 | |a McIntosh, Roger C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Neutrophil to lymphocyte ratio is a transdiagnostic biomarker of depression and structural and functional brain alterations in older adults |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 27.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier B.V. All rights reserved. | ||
| 520 | |a The neutrophil to lymphocyte ratio (N:L) is an emergent transdiagnostic biomarker shown to predict peripheral inflammation as well as neuropsychiatric impairment. The afferent signaling of inflammation to the central nervous system has been implicated in the pathophysiology of sickness behavior and depression. Here, the N:L was compared to structural and functional limbic alterations found concomitant with depression within a geriatric cohort. Venous blood was collected for a complete blood count, and magnetic resonance imaging as well as phenotypic data were collected from the 66 community-dwelling older adults (aged 65-86 years). The N:L was regressed on gray matter volume and resting-state functional connectivity (rsFC) of the subgenual anterior cingulate (sgACC). Thresholded parameter estimates were extracted from structural and functional brain scans and bivariate associations tested with scores on the geriatric depression scale. Greater N:L predicted lower volume of hypothalamus and rsFC of sgACC with ventromedial prefrontal cortex. Both parameters were correlated (p < 0.05) with greater symptomology in those reporting moderate to severe levels of depression. These findings support the N:L as a transdiagnostic biomarker of limbic alteration underpinning mood disturbance in non-treated older adults | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Geriatric depression | |
| 650 | 4 | |a Lymphocytopenia | |
| 650 | 4 | |a Medial frontal cortex | |
| 650 | 4 | |a Neutrophilia | |
| 650 | 4 | |a Perigenual anterior cingulate | |
| 650 | 4 | |a Resting state functional connectivity | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 700 | 1 | |a Lobo, Judith |e verfasserin |4 aut | |
| 700 | 1 | |a Paparozzi, Jeremy |e verfasserin |4 aut | |
| 700 | 1 | |a Goodman, Zach |e verfasserin |4 aut | |
| 700 | 1 | |a Kornfeld, Salome |e verfasserin |4 aut | |
| 700 | 1 | |a Nomi, Jason |e verfasserin |4 aut | |
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