An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge
Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of mice with a pooled vaccine, composed of the three attenuated virus strains expressing each LS antigen, induced sterile protection against the intravenous challenge of Plasmodium yoelii 17X-NL salivary gland sporozoites. Our data suggest that this malaria vaccine may be effective in preventing malaria parasite infection using practical routes of immunization in humans.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Vaccines - 10(2022), 2 vom: 16. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rider, Paul J F [VerfasserIn] |
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| Links: |
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| Themen: |
EXP1 |
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| Anmerkungen: |
Date Revised 28.02.2022 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/vaccines10020300 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337462666 |
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| 245 | 1 | 3 | |a An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of mice with a pooled vaccine, composed of the three attenuated virus strains expressing each LS antigen, induced sterile protection against the intravenous challenge of Plasmodium yoelii 17X-NL salivary gland sporozoites. Our data suggest that this malaria vaccine may be effective in preventing malaria parasite infection using practical routes of immunization in humans | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Kamil, Mohd |e verfasserin |4 aut | |
| 700 | 1 | |a Yilmaz, Ilknur |e verfasserin |4 aut | |
| 700 | 1 | |a Atmaca, Habibe N |e verfasserin |4 aut | |
| 700 | 1 | |a Kalkan-Yazici, Merve |e verfasserin |4 aut | |
| 700 | 1 | |a Ziya Doymaz, Mehmet |e verfasserin |4 aut | |
| 700 | 1 | |a Kousoulas, Konstantin G |e verfasserin |4 aut | |
| 700 | 1 | |a Aly, Ahmed S I |e verfasserin |4 aut | |
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