Outcomes of Children with Unoperated Congenital Heart Disease Admitted to PICU-A Single-Center Experience
© 2022. Dr. K C Chaudhuri Foundation..
OBJECTIVES: To evaluate the outcomes of children with congenital heart disease (CHD) awaiting surgery admitted to a pediatric intensive care unit (PICU) with acute illness.
METHODS: In this retrospective study from a single center, the outcomes of children up to 18 y of age with unoperated CHD admitted to PICU with acute illness and factors affecting the outcomes, were evaluated.
RESULTS: Fifty-eight (41 boys) children were included. Median age was 3.2 (1.5, 6) mo. Thirty-six (62%) children had acyanotic CHD (ACHD), and 22 (38%) had cyanotic CHD (CCHD). Most common ACHD was ventricular septal defect (n = 14; 38.8%) and CCHD was double-outlet right ventricle (n = 6; 27.2%). Twenty-four (41%) children underwent surgery - 10 (41.6%) palliative procedure and 14 (58.3%) corrective procedure. Hospital mortality was 50%. Of the operated children, 37.5% died and of the nonoperated children, 58.8% died. Type of the heart disease and surgical intervention was not associated with mortality (p = 0.27 and 0.11). Requirement of vasoactive agents was associated with increased mortality (p = 0.02). In children with ACHD, factors associated with mortality were lower score for weight for age (p = 0.03) and weight for length (p = 0.04), lower admission pH (p = 0.02), hemodynamic instability at admission (p = 0.002), and requirement of vasoactive agents (p = 0.04).
CONCLUSION: Children with unoperated CHD with acute illness have high morbidity and mortality. Early diagnosis and surgical interventions in children with CHD are warranted.
TRIAL REGISTRATION: Trial Registration No. IECPG-571/21.10.2020.
| Errataetall: |
CommentIn: Indian J Pediatr. 2022 Nov;89(11):1063. - PMID 36063345 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Enthalten in: |
Indian journal of pediatrics - 89(2022), 11 vom: 10. Nov., Seite 1073-1078 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Banothu, Kiran Kumar [VerfasserIn] |
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| Links: |
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| Themen: |
Acute illness |
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| Anmerkungen: |
Date Completed 18.10.2022 Date Revised 04.11.2022 published: Print-Electronic CommentIn: Indian J Pediatr. 2022 Nov;89(11):1063. - PMID 36063345 Citation Status MEDLINE |
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| doi: |
10.1007/s12098-022-04083-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Date Revised 04.11.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Indian J Pediatr. 2022 Nov;89(11):1063. - PMID 36063345 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. Dr. K C Chaudhuri Foundation. | ||
| 520 | |a OBJECTIVES: To evaluate the outcomes of children with congenital heart disease (CHD) awaiting surgery admitted to a pediatric intensive care unit (PICU) with acute illness | ||
| 520 | |a METHODS: In this retrospective study from a single center, the outcomes of children up to 18 y of age with unoperated CHD admitted to PICU with acute illness and factors affecting the outcomes, were evaluated | ||
| 520 | |a RESULTS: Fifty-eight (41 boys) children were included. Median age was 3.2 (1.5, 6) mo. Thirty-six (62%) children had acyanotic CHD (ACHD), and 22 (38%) had cyanotic CHD (CCHD). Most common ACHD was ventricular septal defect (n = 14; 38.8%) and CCHD was double-outlet right ventricle (n = 6; 27.2%). Twenty-four (41%) children underwent surgery - 10 (41.6%) palliative procedure and 14 (58.3%) corrective procedure. Hospital mortality was 50%. Of the operated children, 37.5% died and of the nonoperated children, 58.8% died. Type of the heart disease and surgical intervention was not associated with mortality (p = 0.27 and 0.11). Requirement of vasoactive agents was associated with increased mortality (p = 0.02). In children with ACHD, factors associated with mortality were lower score for weight for age (p = 0.03) and weight for length (p = 0.04), lower admission pH (p = 0.02), hemodynamic instability at admission (p = 0.002), and requirement of vasoactive agents (p = 0.04) | ||
| 520 | |a CONCLUSION: Children with unoperated CHD with acute illness have high morbidity and mortality. Early diagnosis and surgical interventions in children with CHD are warranted | ||
| 520 | |a TRIAL REGISTRATION: Trial Registration No. IECPG-571/21.10.2020 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute illness | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Surgical intervention | |
| 650 | 4 | |a Unoperated congenital heart disease | |
| 700 | 1 | |a Kumar, Arvind |e verfasserin |4 aut | |
| 700 | 1 | |a Agarwal, Sheetal |e verfasserin |4 aut | |
| 700 | 1 | |a Sankar, Jhuma |e verfasserin |4 aut | |
| 700 | 1 | |a Kabra, S K |e verfasserin |4 aut | |
| 700 | 1 | |a Lodha, Rakesh |e verfasserin |4 aut | |
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