LncRNA SNHG15 : A potential therapeutic target in the treatment of colorectal cancer
© 2022 John Wiley & Sons A/S..
The global burden of colorectal cancer (CRC) is increasing annually. CRC could develop from genetic and phenotypic factors involving changes in gene expression. Incredibly, the human genome transcribes into non-coding RNAs, among which long non-coding RNAs (lncRNAs) signify the most crucial part of the transcriptome in multicellular organisms. lncRNAs affect gene expression at multiple levels, from transcription to protein localization and stability. Recent studies have implicated lncRNA small nucleolar RNA host gene 15 (SNHG15) in cancers occurrence and progression. Previously, an indication suggests SNHG15 overexpression triggers proliferation, metastasis, and impedes apoptosis in CRC. Further, through its activity of binding micro-RNAs, lncRNA SNHG15 modulates genes associated with CRC progression and promotes CRC resistance to chemotherapeutic drugs. Here, we reviewed recent findings on the various mechanisms and roles of lncRNA SNHG15 implicated in CRC tumorigenesis. We further highlight how SNHG15 plays a vital role in regulating critical pathways linked to the development and progression of CRC. Finally, we highlight how SNHG15 can be modulated for CRC treatments and the various therapeutic strategies to be implored when targeting SNHG15 in the context of CRC treatments. Findings from these studies present SNHG15 as a potential therapeutic target for preventing and treating CRC.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:101 |
---|---|
Enthalten in: |
Chemical biology & drug design - 101(2023), 5 vom: 07. Mai, Seite 1138-1150 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Olatubosun, Mutolib Olabayo [VerfasserIn] |
---|
Links: |
---|
Themen: |
Colorectal cancer |
---|
Anmerkungen: |
Date Completed 12.04.2023 Date Revised 16.05.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1111/cbdd.14036 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM337229570 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM337229570 | ||
003 | DE-627 | ||
005 | 20231225233935.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1111/cbdd.14036 |2 doi | |
028 | 5 | 2 | |a pubmed24n1124.xml |
035 | |a (DE-627)NLM337229570 | ||
035 | |a (NLM)35191201 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Olatubosun, Mutolib Olabayo |e verfasserin |4 aut | |
245 | 1 | 0 | |a LncRNA SNHG15 |b A potential therapeutic target in the treatment of colorectal cancer |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 12.04.2023 | ||
500 | |a Date Revised 16.05.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2022 John Wiley & Sons A/S. | ||
520 | |a The global burden of colorectal cancer (CRC) is increasing annually. CRC could develop from genetic and phenotypic factors involving changes in gene expression. Incredibly, the human genome transcribes into non-coding RNAs, among which long non-coding RNAs (lncRNAs) signify the most crucial part of the transcriptome in multicellular organisms. lncRNAs affect gene expression at multiple levels, from transcription to protein localization and stability. Recent studies have implicated lncRNA small nucleolar RNA host gene 15 (SNHG15) in cancers occurrence and progression. Previously, an indication suggests SNHG15 overexpression triggers proliferation, metastasis, and impedes apoptosis in CRC. Further, through its activity of binding micro-RNAs, lncRNA SNHG15 modulates genes associated with CRC progression and promotes CRC resistance to chemotherapeutic drugs. Here, we reviewed recent findings on the various mechanisms and roles of lncRNA SNHG15 implicated in CRC tumorigenesis. We further highlight how SNHG15 plays a vital role in regulating critical pathways linked to the development and progression of CRC. Finally, we highlight how SNHG15 can be modulated for CRC treatments and the various therapeutic strategies to be implored when targeting SNHG15 in the context of CRC treatments. Findings from these studies present SNHG15 as a potential therapeutic target for preventing and treating CRC | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a MT | |
650 | 4 | |a SNHG15 | |
650 | 4 | |a Wnt/β-catenin | |
650 | 4 | |a colorectal cancer | |
650 | 4 | |a lncRNA | |
650 | 4 | |a micro-RNAs | |
650 | 7 | |a RNA, Long Noncoding |2 NLM | |
650 | 7 | |a MicroRNAs |2 NLM | |
700 | 1 | |a Abubakar, Murtala Bello |e verfasserin |4 aut | |
700 | 1 | |a Batiha, Gaber El-Saber |e verfasserin |4 aut | |
700 | 1 | |a Malami, Ibrahim |e verfasserin |4 aut | |
700 | 1 | |a Ibrahim, Kasimu Ghandi |e verfasserin |4 aut | |
700 | 1 | |a Abubakar, Bilyaminu |e verfasserin |4 aut | |
700 | 1 | |a Bello, Muhammad Bashir |e verfasserin |4 aut | |
700 | 1 | |a Alexiou, Athanasios |e verfasserin |4 aut | |
700 | 1 | |a Imam, Mustapha Umar |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Chemical biology & drug design |d 2006 |g 101(2023), 5 vom: 07. Mai, Seite 1138-1150 |w (DE-627)NLM160848377 |x 1747-0285 |7 nnns |
773 | 1 | 8 | |g volume:101 |g year:2023 |g number:5 |g day:07 |g month:05 |g pages:1138-1150 |
856 | 4 | 0 | |u http://dx.doi.org/10.1111/cbdd.14036 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 101 |j 2023 |e 5 |b 07 |c 05 |h 1138-1150 |