Coordinately Tethered Iron(III) Fluorescent Nanotheranostic Polymer Ascertaining Cancer Cell Mitochondria Destined Potential Chemotherapy and T1-Weighted MRI Competency
Magnetic resonance imaging-aided real-time diagnosis along with enhanced chemotherapeutic efficacy using a sequential receptor and mitochondria dual-targeting polymer theranostic has become a promising strategy for the effective and precise treatment of cancer. Toward the accomplishment of this goal, chlorambucil (chemotherapeutic agent), biotin (receptor targeting agent), a triphenylphosphonium segment (mitochondriotropic agent), and an iron rhodamine complex (integrated fluorescence-MR imaging agent) were tethered under a single polymer. Owing to the polymer's (RD CH PG BN TP Fe) amphiphilic character, it spontaneously self-assembled into nanospheres, which exhibited a remarkable effect on the relaxation of the water proton. Further, the qualitative estimation of the change in intensity for the water-proton signal reflected its potential as a T1 contrast theranostic polymer. The mitochondria targeting competency of positively charged nanospheres was displayed using fluorescence microscopy in human cervical, HeLa, and breast, MCF-7, carcinoma cell lines. Furthermore, cytotoxicity experiments demonstrated the enhanced anticancer efficacy in both cancer cell lines. Therefore, effective and precise chemotherapy through sequential receptor-mitochondria targeting and integrated fluorescence-MR imaging would have attractive potential for decisive dose-determination by constantly monitoring the subject area of interest.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
ACS applied bio materials - 5(2022), 3 vom: 21. März, Seite 1284-1296 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Patra, Diptendu [VerfasserIn] |
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| Links: |
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| Themen: |
059QF0KO0R |
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| Anmerkungen: |
Date Completed 27.04.2022 Date Revised 27.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acsabm.1c01300 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Magnetic resonance imaging-aided real-time diagnosis along with enhanced chemotherapeutic efficacy using a sequential receptor and mitochondria dual-targeting polymer theranostic has become a promising strategy for the effective and precise treatment of cancer. Toward the accomplishment of this goal, chlorambucil (chemotherapeutic agent), biotin (receptor targeting agent), a triphenylphosphonium segment (mitochondriotropic agent), and an iron rhodamine complex (integrated fluorescence-MR imaging agent) were tethered under a single polymer. Owing to the polymer's (RD CH PG BN TP Fe) amphiphilic character, it spontaneously self-assembled into nanospheres, which exhibited a remarkable effect on the relaxation of the water proton. Further, the qualitative estimation of the change in intensity for the water-proton signal reflected its potential as a T1 contrast theranostic polymer. The mitochondria targeting competency of positively charged nanospheres was displayed using fluorescence microscopy in human cervical, HeLa, and breast, MCF-7, carcinoma cell lines. Furthermore, cytotoxicity experiments demonstrated the enhanced anticancer efficacy in both cancer cell lines. Therefore, effective and precise chemotherapy through sequential receptor-mitochondria targeting and integrated fluorescence-MR imaging would have attractive potential for decisive dose-determination by constantly monitoring the subject area of interest | ||
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