Physical activity and glioma : a case-control study with follow-up for survival
© 2022. The Author(s)..
PURPOSE: High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality.
METHODS: We examined associations between lifetime physical activity and physical activity at different ages (15-18 years, 19-29 years, 30-39 years, last 10 years) with the risk of glioma diagnosis, using data from a hospital-based family case-control study (495 cases; 371 controls). We followed up cases over a median of 25 months to examine whether physical activity was associated with all-cause mortality. Physical activity and potential confounders were assessed by self-administered questionnaire. We examined associations between physical activity (metabolic equivalent [MET]-h/wk) and glioma risk using unconditional logistic regression and with all-cause mortality in cases using Cox regression.
RESULTS: We noted a reduced risk of glioma for the highest (≥ 47 MET-h/wk) versus lowest (< 24 METh/wk) category of physical activity for lifetime activity (OR = 0.58, 95% CI: 0.38-0.89) and at 15-18 years (OR = 0.57, 95% CI: 0.39-0.83). We did not observe any association between physical activity and all-cause mortality (HR for lifetime physical activity = 0.91, 95% CI: 0.64-1.29).
CONCLUSION: Our findings are consistent with previous research that suggested physical activity during adolescence might be protective against glioma. Engaging in physical activity during adolescence has many health benefits; this health behavior may also offer protection against glioma.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
Cancer causes & control : CCC - 33(2022), 5 vom: 19. Mai, Seite 749-757 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Basiri, Zohreh [VerfasserIn] |
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| Links: |
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| Themen: |
Case–control study |
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| Anmerkungen: |
Date Completed 18.04.2022 Date Revised 12.07.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10552-022-01559-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337160821 |
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| 245 | 1 | 0 | |a Physical activity and glioma |b a case-control study with follow-up for survival |
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| 500 | |a Date Revised 12.07.2023 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a PURPOSE: High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality | ||
| 520 | |a METHODS: We examined associations between lifetime physical activity and physical activity at different ages (15-18 years, 19-29 years, 30-39 years, last 10 years) with the risk of glioma diagnosis, using data from a hospital-based family case-control study (495 cases; 371 controls). We followed up cases over a median of 25 months to examine whether physical activity was associated with all-cause mortality. Physical activity and potential confounders were assessed by self-administered questionnaire. We examined associations between physical activity (metabolic equivalent [MET]-h/wk) and glioma risk using unconditional logistic regression and with all-cause mortality in cases using Cox regression | ||
| 520 | |a RESULTS: We noted a reduced risk of glioma for the highest (≥ 47 MET-h/wk) versus lowest (< 24 METh/wk) category of physical activity for lifetime activity (OR = 0.58, 95% CI: 0.38-0.89) and at 15-18 years (OR = 0.57, 95% CI: 0.39-0.83). We did not observe any association between physical activity and all-cause mortality (HR for lifetime physical activity = 0.91, 95% CI: 0.64-1.29) | ||
| 520 | |a CONCLUSION: Our findings are consistent with previous research that suggested physical activity during adolescence might be protective against glioma. Engaging in physical activity during adolescence has many health benefits; this health behavior may also offer protection against glioma | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Case–control study | |
| 650 | 4 | |a Glioma | |
| 650 | 4 | |a Physical activity | |
| 650 | 4 | |a Survival | |
| 700 | 1 | |a Yang, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Bruinsma, Fiona J |e verfasserin |4 aut | |
| 700 | 1 | |a Nowak, Anna K |e verfasserin |4 aut | |
| 700 | 1 | |a McDonald, Kerrie L |e verfasserin |4 aut | |
| 700 | 1 | |a Drummond, Katharine J |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenthal, Mark A |e verfasserin |4 aut | |
| 700 | 1 | |a Koh, Eng-Siew |e verfasserin |4 aut | |
| 700 | 1 | |a Harrup, Rosemary |e verfasserin |4 aut | |
| 700 | 1 | |a Hovey, Elizabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Joseph, David |e verfasserin |4 aut | |
| 700 | 1 | |a Benke, Geza |e verfasserin |4 aut | |
| 700 | 1 | |a Leonard, Robyn |e verfasserin |4 aut | |
| 700 | 1 | |a MacInnis, Robert J |e verfasserin |4 aut | |
| 700 | 1 | |a Milne, Roger L |e verfasserin |4 aut | |
| 700 | 1 | |a Giles, Graham G |e verfasserin |4 aut | |
| 700 | 1 | |a Vajdic, Claire M |e verfasserin |4 aut | |
| 700 | 1 | |a Lynch, Brigid M |e verfasserin |4 aut | |
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