Vitamin K dietary intake is associated with cognitive function in an older adult Mediterranean population
© The Author(s) 2022. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissionsoup.com..
BACKGROUND: In the last years, evidence that dietary vitamin K could have a role in the cognitive domain has increased. However, data from large trials are limited. The objective of this study was to assess the association of 2 year changes in the dietary intake of vitamin K with cognitive function measured through neuropsychological performance tests.
METHODS: In 5,533 participants of the multicentre PREDIMED-Plus study (48.1% women, age 65.1 ± 4.9 years with overweight/obesity and metabolic syndrome), we assessed the adjusted odds ratios of cognitive function decline according to 2 year changes in vitamin K intake. Participants answered a battery of cognitive function tests and Food Frequency Questionnaires (FFQs) in order to estimate the vitamin K dietary intake.
RESULTS: After adjusting for potential cofounders, the highest tertile of change of dietary vitamin K intake (median [IQR]; 194.4 μg/d [120.9, 373.1]) was inversely associated with a Mini-Mental State Examination (MMSE) score ≤24 (OR [95% CI]; 0.53 [0.35, 0.79] P for trend = 0.002) compared with a decrease in the intake of vitamin K (median [IQR]; -97.8 μg/d [-292.8, -51.5]). A significant positive association between changes in dietary vitamin K intake and the semantic verbal fluency test scores (OR [95% CI]; 0.69 [0.51, 0.94] P for trend = 0.019) was found.
CONCLUSIONS: An increase of the intake of dietary vitamin K was associated with better cognitive function scores, independently of recognised risk factors for cognitive decline, in an older adult Mediterranean population with high cardiovascular risk.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
|---|---|
| Enthalten in: |
Age and ageing - 51(2022), 2 vom: 02. Feb. |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
12001-79-5 |
|---|
| Anmerkungen: |
Date Completed 01.04.2022 Date Revised 31.05.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/ageing/afab246 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM337121524 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM337121524 | ||
| 003 | DE-627 | ||
| 005 | 20231225233705.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/ageing/afab246 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1123.xml |
| 035 | |a (DE-627)NLM337121524 | ||
| 035 | |a (NLM)35180284 | ||
| 035 | |a (PII)afab246 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Camacho-Barcia, Lucía |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Vitamin K dietary intake is associated with cognitive function in an older adult Mediterranean population |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 01.04.2022 | ||
| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: In the last years, evidence that dietary vitamin K could have a role in the cognitive domain has increased. However, data from large trials are limited. The objective of this study was to assess the association of 2 year changes in the dietary intake of vitamin K with cognitive function measured through neuropsychological performance tests | ||
| 520 | |a METHODS: In 5,533 participants of the multicentre PREDIMED-Plus study (48.1% women, age 65.1 ± 4.9 years with overweight/obesity and metabolic syndrome), we assessed the adjusted odds ratios of cognitive function decline according to 2 year changes in vitamin K intake. Participants answered a battery of cognitive function tests and Food Frequency Questionnaires (FFQs) in order to estimate the vitamin K dietary intake | ||
| 520 | |a RESULTS: After adjusting for potential cofounders, the highest tertile of change of dietary vitamin K intake (median [IQR]; 194.4 μg/d [120.9, 373.1]) was inversely associated with a Mini-Mental State Examination (MMSE) score ≤24 (OR [95% CI]; 0.53 [0.35, 0.79] P for trend = 0.002) compared with a decrease in the intake of vitamin K (median [IQR]; -97.8 μg/d [-292.8, -51.5]). A significant positive association between changes in dietary vitamin K intake and the semantic verbal fluency test scores (OR [95% CI]; 0.69 [0.51, 0.94] P for trend = 0.019) was found | ||
| 520 | |a CONCLUSIONS: An increase of the intake of dietary vitamin K was associated with better cognitive function scores, independently of recognised risk factors for cognitive decline, in an older adult Mediterranean population with high cardiovascular risk | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Vitamin K | |
| 650 | 4 | |a cognitive impairment | |
| 650 | 4 | |a cognitive-neuropsychological tests | |
| 650 | 4 | |a older people | |
| 650 | 4 | |a phylloquinone | |
| 650 | 7 | |a Vitamin K |2 NLM | |
| 650 | 7 | |a 12001-79-5 |2 NLM | |
| 700 | 1 | |a García-Gavilán, Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-González, Miguel Ángel |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Aranda, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Galié, Serena |e verfasserin |4 aut | |
| 700 | 1 | |a Corella, Dolores |e verfasserin |4 aut | |
| 700 | 1 | |a Cuenca-Royo, Aida |e verfasserin |4 aut | |
| 700 | 1 | |a Romaguera, Dora |e verfasserin |4 aut | |
| 700 | 1 | |a Vioque, Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Alonso-Gómez, Ángel M |e verfasserin |4 aut | |
| 700 | 1 | |a Wärnberg, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez, J Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Serra-Majem, Luís |e verfasserin |4 aut | |
| 700 | 1 | |a Estruch, Ramón |e verfasserin |4 aut | |
| 700 | 1 | |a Bernal-López, M Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Lapetra, José |e verfasserin |4 aut | |
| 700 | 1 | |a Pintó, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Tur, Josep A |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia-Rios, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Bueno-Cavanillas, Aurora |e verfasserin |4 aut | |
| 700 | 1 | |a Delgado-Rodríguez, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Matía-Martín, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Daimiel, Lidia |e verfasserin |4 aut | |
| 700 | 1 | |a Martín-Sánchez, Vicente |e verfasserin |4 aut | |
| 700 | 1 | |a Vidal, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a Vázquez, Clotilde |e verfasserin |4 aut | |
| 700 | 1 | |a Ros, Emilio |e verfasserin |4 aut | |
| 700 | 1 | |a Canela, Miguel Ruiz |e verfasserin |4 aut | |
| 700 | 1 | |a Sorlí, Jose V |e verfasserin |4 aut | |
| 700 | 1 | |a de la Torre, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Konieczna, Jadwiga |e verfasserin |4 aut | |
| 700 | 1 | |a Oncina-Cánovas, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Tojal-Sierra, Lucas |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-López, Jessica |e verfasserin |4 aut | |
| 700 | 1 | |a Abete, Itziar |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Villegas, Almudena |e verfasserin |4 aut | |
| 700 | 1 | |a Casas, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz-Garach, Araceli |e verfasserin |4 aut | |
| 700 | 1 | |a Santos-Lozano, José Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Bouzas, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Razquin, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-Lacruz, Raúl |e verfasserin |4 aut | |
| 700 | 1 | |a Castañer, Olga |e verfasserin |4 aut | |
| 700 | 1 | |a Yañez, Aina M |e verfasserin |4 aut | |
| 700 | 1 | |a Valls-Enguix, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Belló-Mora, Maria Concepción |e verfasserin |4 aut | |
| 700 | 1 | |a Basterra-Gortari, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Basora, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a Salas-Salvadó, Jordi |e verfasserin |4 aut | |
| 700 | 1 | |a Bulló, Mònica |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Age and ageing |d 1972 |g 51(2022), 2 vom: 02. Feb. |w (DE-627)NLM000153109 |x 1468-2834 |7 nnns |
| 773 | 1 | 8 | |g volume:51 |g year:2022 |g number:2 |g day:02 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/ageing/afab246 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 51 |j 2022 |e 2 |b 02 |c 02 | ||