Co-amorphous technology to improve dissolution and physical stability of silybin
The present study explored the effect of co-amorphous technology in improving the dissolution rate and stability of silybin based on the puerarin-silybin co-amorphous system prepared by the spray-drying method. Solid-state characterization was carried out by powder X-ray diffraction(PXRD), polarizing microscopy(PLM), Fourier transform infrared spectroscopy(FT-IR), differential scanning calorimetry(DSC), etc. Saturated powder dissolution, intrinsic dissolution rate, moisture absorption, and stability were further investigated. The results showed that puerarin and silybin formed a co-amorphous system at a single glass transition temperature which was higher than that of any crude drug. The intrinsic dissolution rate and supersaturated powder dissolution of silybin in the co-amorphous system were higher than those of the crude drug and amorphous system. The co-amorphous system kept stable for as long as three months under the condition of 40 ℃, 75% relative humidity, which was longer than that of the single amorphous silybin. Therefore, the co-amorphous technology could significantly improve the dissolution and stability of silybin.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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| Enthalten in: |
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica - 47(2022), 1 vom: 14. Jan., Seite 103-110 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Liu, Huan [VerfasserIn] |
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| Links: |
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| Themen: |
4RKY41TBTF |
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| Anmerkungen: |
Date Completed 21.02.2022 Date Revised 21.02.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.19540/j.cnki.cjcmm.20210511.301 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337107971 |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The present study explored the effect of co-amorphous technology in improving the dissolution rate and stability of silybin based on the puerarin-silybin co-amorphous system prepared by the spray-drying method. Solid-state characterization was carried out by powder X-ray diffraction(PXRD), polarizing microscopy(PLM), Fourier transform infrared spectroscopy(FT-IR), differential scanning calorimetry(DSC), etc. Saturated powder dissolution, intrinsic dissolution rate, moisture absorption, and stability were further investigated. The results showed that puerarin and silybin formed a co-amorphous system at a single glass transition temperature which was higher than that of any crude drug. The intrinsic dissolution rate and supersaturated powder dissolution of silybin in the co-amorphous system were higher than those of the crude drug and amorphous system. The co-amorphous system kept stable for as long as three months under the condition of 40 ℃, 75% relative humidity, which was longer than that of the single amorphous silybin. Therefore, the co-amorphous technology could significantly improve the dissolution and stability of silybin | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a co-amorphous | |
| 650 | 4 | |a dissolution | |
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| 650 | 4 | |a silybin | |
| 650 | 4 | |a stability | |
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| 700 | 1 | |a Zhao, Guo-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Qie-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Xin-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Ouyang, Liao-Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Hai-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xu-Long |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Zheng-Gen |e verfasserin |4 aut | |
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