99mTc-BBPA] : A possible SPECT agent to understand the role of 18-kDa translocator protein (PBR/TSPO) during neuro-glial interaction
Copyright © 2022 Elsevier Inc. All rights reserved..
The translocator protein (TSPO, 18 kDa) is one of the most promising biomarker to understand the role of neuroinflammation in human as well as in different animal species. Here we report a new TSPO-selective ligand 2-(5-(2-(bis(pyridin-2-yl methyl)amino)acetamido)-2-oxobenzo[d] oxazol-3(2H)-yl)-N-methyl-N-phenylacetamide, BBPA, which is supposed to be a potential probe to understand the role of TSPO in neuro-glial interaction through SPECT modality.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:121 |
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| Enthalten in: |
Bioorganic chemistry - 121(2022) vom: 15. Apr., Seite 105678 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kumari, Neelam [VerfasserIn] |
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| Links: |
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| Themen: |
(99m)Tc |
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| Anmerkungen: |
Date Completed 19.04.2022 Date Revised 19.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bioorg.2022.105678 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337084521 |
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| 520 | |a The translocator protein (TSPO, 18 kDa) is one of the most promising biomarker to understand the role of neuroinflammation in human as well as in different animal species. Here we report a new TSPO-selective ligand 2-(5-(2-(bis(pyridin-2-yl methyl)amino)acetamido)-2-oxobenzo[d] oxazol-3(2H)-yl)-N-methyl-N-phenylacetamide, BBPA, which is supposed to be a potential probe to understand the role of TSPO in neuro-glial interaction through SPECT modality | ||
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| 650 | 4 | |a TSPO | |
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| 700 | 1 | |a Mishra, Gauri |e verfasserin |4 aut | |
| 700 | 1 | |a Bhagat, Sunita |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Vinay Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a KumarTiwari, Anjani |e verfasserin |4 aut | |
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