Sleep-disordered Breathing in Pregnancy and after Delivery : Associations with Cardiometabolic Health
Rationale: Knowledge gaps exist regarding health implications of sleep-disordered breathing (SDB) identified in pregnancy and/or after delivery. Objectives: To determine whether SDB in pregnancy and/or after delivery is associated with hypertension (HTN) and metabolic syndrome (MS). Methods: nuMoM2b-HHS (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Heart Health Study) (N = 4,508) followed participants initially recruited during their first pregnancy. Participants returned for a visit 2-7 years after pregnancy. This study examined a subgroup who underwent SDB assessments during their first pregnancy (n = 1,964) and a repeat SDB assessment after delivery (n = 1,222). Two SDB definitions were considered: 1) apnea-hypopnea index (AHI) ⩾ 5 and 2) oxygen desaturation index (ODI) ⩾ 5. Associations between SDB and incident HTN and MS were evaluated with adjusted risk ratios (aRRs). Measurements and Main Results: The aRR for MS given an AHI ⩾ 5 during pregnancy was 1.44 (95% confidence interval [CI], 1.08-1.93), but no association with HTN was found. ODI ⩾ 5 in pregnancy was associated with both an increased risk for HTN (aRR, 2.02; 95% CI, 1.30-3.14) and MS (aRR, 1.53; 95% CI, 1.19-1.97). Participants with an AHI ⩾ 5 in pregnancy that persisted after delivery were at higher risk for both HTN (aRR, 3.77; 95% CI, 1.84-7.73) and MS (aRR, 2.46; 95% CI, 1.59-3.76). Similar associations were observed for persistent ODI ⩾ 5 after delivery. Conclusions: An AHI ⩾ 5 in pregnancy was associated with an increased risk of MS. An ODI ⩾ 5 in pregnancy was significantly associated with both HTN and MS. Participants with persistent elevations in AHI and ODI during pregnancy and at 2-7 years after delivery were at the highest risk for HTN and MS. Clinical trial registered with www.clinicaltrials.gov (NCT02231398).
Errataetall: |
CommentIn: Am J Respir Crit Care Med. 2022 May 15;205(10):1140-1142. - PMID 35333144 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:205 |
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Enthalten in: |
American journal of respiratory and critical care medicine - 205(2022), 10 vom: 15. Mai, Seite 1202-1213 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Facco, Francesca L [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 17.05.2022 Date Revised 16.05.2023 published: Print ClinicalTrials.gov: NCT02231398 CommentIn: Am J Respir Crit Care Med. 2022 May 15;205(10):1140-1142. - PMID 35333144 Citation Status MEDLINE |
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doi: |
10.1164/rccm.202104-0971OC |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM336767218 |
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500 | |a ClinicalTrials.gov: NCT02231398 | ||
500 | |a CommentIn: Am J Respir Crit Care Med. 2022 May 15;205(10):1140-1142. - PMID 35333144 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Rationale: Knowledge gaps exist regarding health implications of sleep-disordered breathing (SDB) identified in pregnancy and/or after delivery. Objectives: To determine whether SDB in pregnancy and/or after delivery is associated with hypertension (HTN) and metabolic syndrome (MS). Methods: nuMoM2b-HHS (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Heart Health Study) (N = 4,508) followed participants initially recruited during their first pregnancy. Participants returned for a visit 2-7 years after pregnancy. This study examined a subgroup who underwent SDB assessments during their first pregnancy (n = 1,964) and a repeat SDB assessment after delivery (n = 1,222). Two SDB definitions were considered: 1) apnea-hypopnea index (AHI) ⩾ 5 and 2) oxygen desaturation index (ODI) ⩾ 5. Associations between SDB and incident HTN and MS were evaluated with adjusted risk ratios (aRRs). Measurements and Main Results: The aRR for MS given an AHI ⩾ 5 during pregnancy was 1.44 (95% confidence interval [CI], 1.08-1.93), but no association with HTN was found. ODI ⩾ 5 in pregnancy was associated with both an increased risk for HTN (aRR, 2.02; 95% CI, 1.30-3.14) and MS (aRR, 1.53; 95% CI, 1.19-1.97). Participants with an AHI ⩾ 5 in pregnancy that persisted after delivery were at higher risk for both HTN (aRR, 3.77; 95% CI, 1.84-7.73) and MS (aRR, 2.46; 95% CI, 1.59-3.76). Similar associations were observed for persistent ODI ⩾ 5 after delivery. Conclusions: An AHI ⩾ 5 in pregnancy was associated with an increased risk of MS. An ODI ⩾ 5 in pregnancy was significantly associated with both HTN and MS. Participants with persistent elevations in AHI and ODI during pregnancy and at 2-7 years after delivery were at the highest risk for HTN and MS. Clinical trial registered with www.clinicaltrials.gov (NCT02231398) | ||
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650 | 4 | |a cardiometabolic health | |
650 | 4 | |a hypertension | |
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700 | 1 | |a Hunter, Shannon M |e verfasserin |4 aut | |
700 | 1 | |a Zee, Phyllis C |e verfasserin |4 aut | |
700 | 1 | |a Grobman, William A |e verfasserin |4 aut | |
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700 | 1 | |a Parry, Samuel |e verfasserin |4 aut | |
700 | 1 | |a Reddy, Uma |e verfasserin |4 aut | |
700 | 1 | |a Saade, George R |e verfasserin |4 aut | |
700 | 1 | |a Hoffman, Matthew K |e verfasserin |4 aut | |
700 | 1 | |a Levine, Lisa D |e verfasserin |4 aut | |
700 | 1 | |a Wapner, Ronald J |e verfasserin |4 aut | |
700 | 1 | |a Catov, Janet M |e verfasserin |4 aut | |
700 | 1 | |a Parker, Corette B |e verfasserin |4 aut | |
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