Effects of Attendance to an Organized Fecal Immunochemical Test Screening Program on the Risk of Colorectal Cancer : An Observational Cohort Study
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved..
BACKGROUND & AIMS: This cohort study compared colorectal cancer (CRC) incidence and mortality between people who participated in an Italian regional biennial fecal immunochemical test (FIT) screening program and people who did not.
METHODS: The program started in 2005. The target population included over 1,000,000 people aged 50 to 69 years. The FIT was a one-sample OC-Sensor (Eiken Chemical Co, Tokyo, Japan) (cutoff, ≥20 μg hemoglobin/g feces). The average annual response rate to invitation was 51.4%. The records of people invited up to June 2016 were extracted from the screening data warehouse. Attenders were subjects who responded to the first 2 invitations or to the single invitation sent them before they became ineligible. Non-attenders were subjects who did not respond to any of these invitations. The records were linked with the regional CRC registry. People registered up to December 2016 were identified. Self-selection-adjusted incidence rate ratios (IRRs) and incidence-based CRC mortality rate ratios (MRRs) for attenders to non-attenders, with 95% confidence intervals (CIs), were calculated.
RESULTS: The cohort generated 2,622,131 man-years and 2,887,845 woman-years at risk with 4490 and 3309 CRC cases, respectively. The cohort of attenders was associated with an IRR of 0.65 (95% CI, 0.61-0.69) for men, 0.75 (95% CI, 0.70-0.80) for women and 0.69 (95% CI, 0.66-0.72) for both sexes combined. The self-selection-adjusted IRR was 0.67 (95% CI, 0.62-0.72) for men and 0.79 (95% CI, 0.72-0.88) for women. The IRR for stage I, II, III, and IV CRC was 1.35 (95% CI, 1.20-1.50), 0.61 (95% CI, 0.53-0.69), 0.60 (95% CI, 0.53-0.68) and 0.28 (95% CI, 0.24-0.32) for men and 1.64 (95% CI, 1.43-1.89), 0.60 (95% CI, 0.52-0.69), 0.73 (95% CI, 0.63-0.85) and 0.35 (95% CI, 0.30-0.42) for women. The overall incidence-based CRC MRR was 0.32 (95% CI, 0.28-0.37) for men, 0.40 (95% CI, 0.34-0.47) for women and 0.35 (95% CI, 0.31-0.39) for both sexes combined. The adjusted MRR was 0.35 (95% CI, 0.29-0.41) for men and 0.46 (95% CI, 0.37-0.58) for women.
CONCLUSIONS: Attendance to a FIT screening program is associated with a CRC incidence reduction of 33% among men and 21% among women, and a CRC mortality reduction of 65% and 54%, respectively.
| Errataetall: |
CommentIn: Clin Gastroenterol Hepatol. 2022 Oct;20(10):2216-2217. - PMID 35390510 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 20(2022), 10 vom: 01. Okt., Seite 2373-2382 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Baldacchini, Flavia [VerfasserIn] |
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| Links: |
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| Themen: |
Cohort Study |
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| Anmerkungen: |
Date Completed 28.09.2022 Date Revised 09.11.2022 published: Print-Electronic CommentIn: Clin Gastroenterol Hepatol. 2022 Oct;20(10):2216-2217. - PMID 35390510 Citation Status MEDLINE |
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| doi: |
10.1016/j.cgh.2022.01.053 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM336762305 |
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| 245 | 1 | 0 | |a Effects of Attendance to an Organized Fecal Immunochemical Test Screening Program on the Risk of Colorectal Cancer |b An Observational Cohort Study |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Clin Gastroenterol Hepatol. 2022 Oct;20(10):2216-2217. - PMID 35390510 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND & AIMS: This cohort study compared colorectal cancer (CRC) incidence and mortality between people who participated in an Italian regional biennial fecal immunochemical test (FIT) screening program and people who did not | ||
| 520 | |a METHODS: The program started in 2005. The target population included over 1,000,000 people aged 50 to 69 years. The FIT was a one-sample OC-Sensor (Eiken Chemical Co, Tokyo, Japan) (cutoff, ≥20 μg hemoglobin/g feces). The average annual response rate to invitation was 51.4%. The records of people invited up to June 2016 were extracted from the screening data warehouse. Attenders were subjects who responded to the first 2 invitations or to the single invitation sent them before they became ineligible. Non-attenders were subjects who did not respond to any of these invitations. The records were linked with the regional CRC registry. People registered up to December 2016 were identified. Self-selection-adjusted incidence rate ratios (IRRs) and incidence-based CRC mortality rate ratios (MRRs) for attenders to non-attenders, with 95% confidence intervals (CIs), were calculated | ||
| 520 | |a RESULTS: The cohort generated 2,622,131 man-years and 2,887,845 woman-years at risk with 4490 and 3309 CRC cases, respectively. The cohort of attenders was associated with an IRR of 0.65 (95% CI, 0.61-0.69) for men, 0.75 (95% CI, 0.70-0.80) for women and 0.69 (95% CI, 0.66-0.72) for both sexes combined. The self-selection-adjusted IRR was 0.67 (95% CI, 0.62-0.72) for men and 0.79 (95% CI, 0.72-0.88) for women. The IRR for stage I, II, III, and IV CRC was 1.35 (95% CI, 1.20-1.50), 0.61 (95% CI, 0.53-0.69), 0.60 (95% CI, 0.53-0.68) and 0.28 (95% CI, 0.24-0.32) for men and 1.64 (95% CI, 1.43-1.89), 0.60 (95% CI, 0.52-0.69), 0.73 (95% CI, 0.63-0.85) and 0.35 (95% CI, 0.30-0.42) for women. The overall incidence-based CRC MRR was 0.32 (95% CI, 0.28-0.37) for men, 0.40 (95% CI, 0.34-0.47) for women and 0.35 (95% CI, 0.31-0.39) for both sexes combined. The adjusted MRR was 0.35 (95% CI, 0.29-0.41) for men and 0.46 (95% CI, 0.37-0.58) for women | ||
| 520 | |a CONCLUSIONS: Attendance to a FIT screening program is associated with a CRC incidence reduction of 33% among men and 21% among women, and a CRC mortality reduction of 65% and 54%, respectively | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Cohort Study | |
| 650 | 4 | |a Colorectal Cancer | |
| 650 | 4 | |a Fecal Immunochemical Test | |
| 650 | 4 | |a Incidence | |
| 650 | 4 | |a Mass Screening | |
| 650 | 7 | |a Hemoglobins |2 NLM | |
| 700 | 1 | |a Bucchi, Lauro |e verfasserin |4 aut | |
| 700 | 1 | |a Giuliani, Orietta |e verfasserin |4 aut | |
| 700 | 1 | |a Mancini, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Ravaioli, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Vattiato, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Zamagni, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Giorgi Rossi, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Mangone, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Campari, Cinzia |e verfasserin |4 aut | |
| 700 | 1 | |a Sassatelli, Romano |e verfasserin |4 aut | |
| 700 | 1 | |a Trande, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Esposito, Pasqualina |e verfasserin |4 aut | |
| 700 | 1 | |a Rossi, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Carrozzi, Giuliano |e verfasserin |4 aut | |
| 700 | 1 | |a Triossi, Omero |e verfasserin |4 aut | |
| 700 | 1 | |a Fabbri, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Strocchi, Enrico |e verfasserin |4 aut | |
| 700 | 1 | |a Giovanardi, Mauro |e verfasserin |4 aut | |
| 700 | 1 | |a Canuti, Debora |e verfasserin |4 aut | |
| 700 | 1 | |a Sassoli de Bianchi, Priscilla |e verfasserin |4 aut | |
| 700 | 1 | |a Ferretti, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Falcini, Fabio |e verfasserin |4 aut | |
| 700 | 0 | |a Emilia-Romagna Region Workgroup for Colorectal Screening Evaluation |e verfasserin |4 aut | |
| 700 | 1 | |a Finarelli, Alba Carola |e investigator |4 oth | |
| 700 | 1 | |a Landi, Patrizia |e investigator |4 oth | |
| 700 | 1 | |a Mezzetti, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Naldoni, Carlo |e investigator |4 oth | |
| 700 | 1 | |a Sassoli de Bianchi, Priscilla |e investigator |4 oth | |
| 700 | 1 | |a Ferretti, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Baldacchini, Flavia |e investigator |4 oth | |
| 700 | 1 | |a Bucchi, Lauro |e investigator |4 oth | |
| 700 | 1 | |a Giuliani, Orietta |e investigator |4 oth | |
| 700 | 1 | |a Mancini, Silvia |e investigator |4 oth | |
| 700 | 1 | |a Ravaioli, Alessandra |e investigator |4 oth | |
| 700 | 1 | |a Zamagni, Federica |e investigator |4 oth | |
| 700 | 1 | |a Vattiato, Rosa |e investigator |4 oth | |
| 700 | 1 | |a Balducci, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Vitali, Benedetta |e investigator |4 oth | |
| 700 | 1 | |a Falcini, Fabio |e investigator |4 oth | |
| 700 | 1 | |a Aragona, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Chiaranda, Giorgio |e investigator |4 oth | |
| 700 | 1 | |a Penini, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Seghini, Pietro |e investigator |4 oth | |
| 700 | 1 | |a Dalla Fiora, Cristian |e investigator |4 oth | |
| 700 | 1 | |a Fattibene, Claudio |e investigator |4 oth | |
| 700 | 1 | |a Maradini, Fabio |e investigator |4 oth | |
| 700 | 1 | |a Orsi, Paolo |e investigator |4 oth | |
| 700 | 1 | |a Benedetta Giannino, Giada Maria |e investigator |4 oth | |
| 700 | 1 | |a Michiara, Maria |e investigator |4 oth | |
| 700 | 1 | |a Giorgi Rossi, Paolo |e investigator |4 oth | |
| 700 | 1 | |a Mangone, Lucia |e investigator |4 oth | |
| 700 | 1 | |a Campari, Cinzia |e investigator |4 oth | |
| 700 | 1 | |a Paterlini, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Sassatelli, Romano |e investigator |4 oth | |
| 700 | 1 | |a Carrozzi, Giuliano |e investigator |4 oth | |
| 700 | 1 | |a Gianfranco, De Girolamo |e investigator |4 oth | |
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| 700 | 1 | |a Viani, Simona |e investigator |4 oth | |
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| 700 | 1 | |a Cennamo, Vincenzo |e investigator |4 oth | |
| 700 | 1 | |a Giansante, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Gualandi, Giovanna |e investigator |4 oth | |
| 700 | 1 | |a Manfredi, Marilena |e investigator |4 oth | |
| 700 | 1 | |a Mezzetti, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Pasquini, Adriana |e investigator |4 oth | |
| 700 | 1 | |a Caprara, Licia |e investigator |4 oth | |
| 700 | 1 | |a De Lillo, Margherita |e investigator |4 oth | |
| 700 | 1 | |a De Togni, Aldo |e investigator |4 oth | |
| 700 | 1 | |a Palmonari, Caterina |e investigator |4 oth | |
| 700 | 1 | |a Pasquali, Daniela |e investigator |4 oth | |
| 700 | 1 | |a Zoli, Giorgio |e investigator |4 oth | |
| 700 | 1 | |a Dal Re, Serena |e investigator |4 oth | |
| 700 | 1 | |a Petrini, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Serafini, Monica |e investigator |4 oth | |
| 700 | 1 | |a Triossi, Omero |e investigator |4 oth | |
| 700 | 1 | |a Gallinucci, Mara |e investigator |4 oth | |
| 700 | 1 | |a Imolesi, Claudia |e investigator |4 oth | |
| 700 | 1 | |a Palazzi, Mauro |e investigator |4 oth | |
| 700 | 1 | |a Canuti, Debora |e investigator |4 oth | |
| 700 | 1 | |a Casale, Coralba |e investigator |4 oth | |
| 700 | 1 | |a Giovanardi, Mauro |e investigator |4 oth | |
| 700 | 1 | |a Trombetti, Daniele |e investigator |4 oth | |
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