Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome
Copyright © 2022 Shilts, Rosas-Salazar, Strickland, Kimura, Asad, Sehanobish, Freeman, Wessinger, Gupta, Brown, Boone, Patel, Barbi, Bottalico, O’Neill, Akbar, Rajagopala, Mallal, Phillips, Turner, Jerschow and Das..
Background: The upper respiratory tract (URT) is the portal of entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with the URT microbiome. However, understanding of the associations between the URT microbiome and the severity of coronavirus disease 2019 (COVID-19) is still limited.
Objective: Our primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity.
Methods: Using data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19.
Results: URT bacterial load, bacterial richness, and within-group microbiome composition dissimilarity consistently increased as COVID-19 severity increased, while the relative abundance of an amplicon sequence variant (ASV), Corynebacterium_unclassified.ASV0002, consistently decreased as COVID-19 severity increased.
Conclusions: We observed that the URT microbiome composition significantly changed as COVID-19 severity increased. The URT microbiome could potentially predict which patients may be more likely to progress to severe disease or be modified to decrease severity. However, further research in additional longitudinal cohorts is needed to better understand how the microbiome affects COVID-19 severity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Frontiers in cellular and infection microbiology - 11(2021) vom: 16., Seite 781968 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shilts, Meghan H [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 14.02.2022 Date Revised 19.07.2023 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fcimb.2021.781968 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Date Revised 19.07.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Shilts, Rosas-Salazar, Strickland, Kimura, Asad, Sehanobish, Freeman, Wessinger, Gupta, Brown, Boone, Patel, Barbi, Bottalico, O’Neill, Akbar, Rajagopala, Mallal, Phillips, Turner, Jerschow and Das. | ||
| 520 | |a Background: The upper respiratory tract (URT) is the portal of entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with the URT microbiome. However, understanding of the associations between the URT microbiome and the severity of coronavirus disease 2019 (COVID-19) is still limited | ||
| 520 | |a Objective: Our primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity | ||
| 520 | |a Methods: Using data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19 | ||
| 520 | |a Results: URT bacterial load, bacterial richness, and within-group microbiome composition dissimilarity consistently increased as COVID-19 severity increased, while the relative abundance of an amplicon sequence variant (ASV), Corynebacterium_unclassified.ASV0002, consistently decreased as COVID-19 severity increased | ||
| 520 | |a Conclusions: We observed that the URT microbiome composition significantly changed as COVID-19 severity increased. The URT microbiome could potentially predict which patients may be more likely to progress to severe disease or be modified to decrease severity. However, further research in additional longitudinal cohorts is needed to better understand how the microbiome affects COVID-19 severity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a microbiome | |
| 650 | 4 | |a mild | |
| 650 | 4 | |a moderate | |
| 650 | 4 | |a severe COVID-19 outcomes | |
| 650 | 4 | |a upper respiratory tract | |
| 700 | 1 | |a Rosas-Salazar, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Strickland, Britton A |e verfasserin |4 aut | |
| 700 | 1 | |a Kimura, Kyle S |e verfasserin |4 aut | |
| 700 | 1 | |a Asad, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Sehanobish, Esha |e verfasserin |4 aut | |
| 700 | 1 | |a Freeman, Michael H |e verfasserin |4 aut | |
| 700 | 1 | |a Wessinger, Bronson C |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Veerain |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Hunter M |e verfasserin |4 aut | |
| 700 | 1 | |a Boone, Helen H |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Viraj |e verfasserin |4 aut | |
| 700 | 1 | |a Barbi, Mali |e verfasserin |4 aut | |
| 700 | 1 | |a Bottalico, Danielle |e verfasserin |4 aut | |
| 700 | 1 | |a O'Neill, Meaghan |e verfasserin |4 aut | |
| 700 | 1 | |a Akbar, Nadeem |e verfasserin |4 aut | |
| 700 | 1 | |a Rajagopala, Seesandra V |e verfasserin |4 aut | |
| 700 | 1 | |a Mallal, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Phillips, Elizabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Turner, Justin H |e verfasserin |4 aut | |
| 700 | 1 | |a Jerschow, Elina |e verfasserin |4 aut | |
| 700 | 1 | |a Das, Suman R |e verfasserin |4 aut | |
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