The Relationship between Epicardial Fat and Atrial Fibrillation Cannot Be Fully Explained by Left Atrial Fibrosis
BACKGROUND: Epicardial adipose tissue (EAT) has been associated with atrial fibrillation (AF), but its pathophysiological mechanisms remain unclear.
OBJECTIVES: To measure the correlation between EAT and left atrium (LA) fibrosis, and to assess their ability to predict relapse after pulmonary vein isolation (PVI).
METHODS: Patients with AF enrolled for a first PVI procedure underwent both cardiac computerized tomography (CT) and cardiac magnetic resonance (CMR) imaging within less than 48 hours. EATLMwas quantified on contrast-enhanced CT images at the level of the left main. LA fibrosis was quantified on isotropic 1.5 mm 3D delayed enhancement CMR. After pulmonary vein isolation (PVI), patients were followed up for AF relapse. Statistical significance was set at p<0.05.
RESULTS: Most of the 68 patients (46 men, age 61±12 years) had paroxysmal AF (71%, n=48). Patients had a median EATLMvolume of 2.4 cm3/m2(interquartile range [IQR] 1.6-3.2 cm3/m2), and a median amount of LA fibrosis of 8.9 g (IQR 5-15 g). The correlation between EATLMand LA fibrosis was statistically significant but weak (Spearman's R=0.40, p=0.001). During a median follow-up of 22 months (IQR 12-31), 31 patients (46%) had AF relapse. Multivariate analysis yielded two independent predictors of AF relapse: EATLM(HR 2.05, 95% CI 1.51-2.79, p<0.001), and non-paroxysmal AF (HR 2.36, 95% CI 1.08-5.16, p=0.031).
CONCLUSION: The weak correlation between EAT and LA suggests that LA fibrosis is not the main mechanism linking EAT and AF. EAT was more strongly associated with AF relapse than LA fibrosis, supporting the existence of other more important mediators of EAT and AF.
| Errataetall: |
CommentIn: Arq Bras Cardiol. 2022 Apr;118(4):743-744. - PMID 35508051 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:118 |
|---|---|
| Enthalten in: |
Arquivos brasileiros de cardiologia - 118(2022), 4 vom: 15. Apr., Seite 737-742 |
| Sprache: |
Englisch |
|---|
| Weiterer Titel: |
Relação entre Gordura Epicárdica e Fibrilação Atrial Não Pode Ser Totalmente Explicada pela Fibrose Atrial Esquerda |
|---|
| Beteiligte Personen: |
Matos, Daniel [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 06.05.2022 Date Revised 21.06.2022 published: Print CommentIn: Arq Bras Cardiol. 2022 Apr;118(4):743-744. - PMID 35508051 Citation Status MEDLINE |
|---|
| doi: |
10.36660/abc.20201083 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM336701098 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM336701098 | ||
| 003 | DE-627 | ||
| 005 | 20231225232734.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.36660/abc.20201083 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1122.xml |
| 035 | |a (DE-627)NLM336701098 | ||
| 035 | |a (NLM)35137779 | ||
| 035 | |a (PII)S0066-782X2022000400737 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Matos, Daniel |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Relationship between Epicardial Fat and Atrial Fibrillation Cannot Be Fully Explained by Left Atrial Fibrosis |
| 246 | 3 | 3 | |a Relação entre Gordura Epicárdica e Fibrilação Atrial Não Pode Ser Totalmente Explicada pela Fibrose Atrial Esquerda |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.05.2022 | ||
| 500 | |a Date Revised 21.06.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Arq Bras Cardiol. 2022 Apr;118(4):743-744. - PMID 35508051 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Epicardial adipose tissue (EAT) has been associated with atrial fibrillation (AF), but its pathophysiological mechanisms remain unclear | ||
| 520 | |a OBJECTIVES: To measure the correlation between EAT and left atrium (LA) fibrosis, and to assess their ability to predict relapse after pulmonary vein isolation (PVI) | ||
| 520 | |a METHODS: Patients with AF enrolled for a first PVI procedure underwent both cardiac computerized tomography (CT) and cardiac magnetic resonance (CMR) imaging within less than 48 hours. EATLMwas quantified on contrast-enhanced CT images at the level of the left main. LA fibrosis was quantified on isotropic 1.5 mm 3D delayed enhancement CMR. After pulmonary vein isolation (PVI), patients were followed up for AF relapse. Statistical significance was set at p<0.05 | ||
| 520 | |a RESULTS: Most of the 68 patients (46 men, age 61±12 years) had paroxysmal AF (71%, n=48). Patients had a median EATLMvolume of 2.4 cm3/m2(interquartile range [IQR] 1.6-3.2 cm3/m2), and a median amount of LA fibrosis of 8.9 g (IQR 5-15 g). The correlation between EATLMand LA fibrosis was statistically significant but weak (Spearman's R=0.40, p=0.001). During a median follow-up of 22 months (IQR 12-31), 31 patients (46%) had AF relapse. Multivariate analysis yielded two independent predictors of AF relapse: EATLM(HR 2.05, 95% CI 1.51-2.79, p<0.001), and non-paroxysmal AF (HR 2.36, 95% CI 1.08-5.16, p=0.031) | ||
| 520 | |a CONCLUSION: The weak correlation between EAT and LA suggests that LA fibrosis is not the main mechanism linking EAT and AF. EAT was more strongly associated with AF relapse than LA fibrosis, supporting the existence of other more important mediators of EAT and AF | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Ferreira, António Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Freitas, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues, Gustavo |e verfasserin |4 aut | |
| 700 | 1 | |a Carmo, João |e verfasserin |4 aut | |
| 700 | 1 | |a Costa, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Abecasis, João |e verfasserin |4 aut | |
| 700 | 1 | |a Carmo, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Saraiva, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Cavaco, Diogo |e verfasserin |4 aut | |
| 700 | 1 | |a Morgado, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Mendes, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Adragao, Pedro |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Arquivos brasileiros de cardiologia |d 1950 |g 118(2022), 4 vom: 15. Apr., Seite 737-742 |w (DE-627)NLM000272981 |x 1678-4170 |7 nnns |
| 773 | 1 | 8 | |g volume:118 |g year:2022 |g number:4 |g day:15 |g month:04 |g pages:737-742 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.36660/abc.20201083 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 118 |j 2022 |e 4 |b 15 |c 04 |h 737-742 | ||