A multicentre study of clinical features and HLA typing in Japanese patients with ankylosing spondylitis
© Japan College of Rheumatology 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
OBJECTIVES: Due to the low prevalence of HLA-B27 and ankylosing spondylitis (AS) in Japan, rheumatologists have little experience with AS. We conducted a multicentre study to identify the characteristics and frequency of HLA-B types.
METHODS: We analysed epidemiological and clinical data, blood tests, spine radiographs, and HLA-B types in Japanese AS patients.
RESULTS: We evaluated 111 AS patients, predominantly men (82.9%). The mean age, disease onset, diagnosis, and time from onset to diagnosis were 43.7, 24.2, 36.0, and 11.6 years, respectively. Inflammatory low back pain was found in 96 cases (86.5%); peripheral arthritis in 59 (53.2%), enthesitis in 35 (31.5%), and dactylitis in 6 (5.4%). Extra-articular symptoms included uveitis, psoriasis, and inflammatory bowel disease in 41 (36.9%), 1 (0.9%), and 5 (4.5%) cases, respectively. HLA-B27 was positive in 83 cases (74.8%; odds ratio, 1146.0); and HLA-B48 in 9 (8.1%; odds ratio, 3.0). HLA-B27-positive patients were younger at onset and had a shorter diagnostic delay.
CONCLUSIONS: AS clinical symptoms were almost the same as other countries except for the low coexistence of psoriasis. HLA-B27 positivity in Japanese patients was 78%. HLA-B27-positive patients were younger and diagnosed earlier. In addition to HLA-B27, a relationship with HLA-B48 was suggested.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
Modern rheumatology - 33(2023), 2 vom: 02. März, Seite 392-397 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tada, Kurisu [VerfasserIn] |
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| Links: |
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| Themen: |
Ankylosing spondylitis |
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| Anmerkungen: |
Date Completed 06.03.2023 Date Revised 06.03.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/mr/roac008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM336695063 |
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| 245 | 1 | 2 | |a A multicentre study of clinical features and HLA typing in Japanese patients with ankylosing spondylitis |
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| 520 | |a © Japan College of Rheumatology 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a OBJECTIVES: Due to the low prevalence of HLA-B27 and ankylosing spondylitis (AS) in Japan, rheumatologists have little experience with AS. We conducted a multicentre study to identify the characteristics and frequency of HLA-B types | ||
| 520 | |a METHODS: We analysed epidemiological and clinical data, blood tests, spine radiographs, and HLA-B types in Japanese AS patients | ||
| 520 | |a RESULTS: We evaluated 111 AS patients, predominantly men (82.9%). The mean age, disease onset, diagnosis, and time from onset to diagnosis were 43.7, 24.2, 36.0, and 11.6 years, respectively. Inflammatory low back pain was found in 96 cases (86.5%); peripheral arthritis in 59 (53.2%), enthesitis in 35 (31.5%), and dactylitis in 6 (5.4%). Extra-articular symptoms included uveitis, psoriasis, and inflammatory bowel disease in 41 (36.9%), 1 (0.9%), and 5 (4.5%) cases, respectively. HLA-B27 was positive in 83 cases (74.8%; odds ratio, 1146.0); and HLA-B48 in 9 (8.1%; odds ratio, 3.0). HLA-B27-positive patients were younger at onset and had a shorter diagnostic delay | ||
| 520 | |a CONCLUSIONS: AS clinical symptoms were almost the same as other countries except for the low coexistence of psoriasis. HLA-B27 positivity in Japanese patients was 78%. HLA-B27-positive patients were younger and diagnosed earlier. In addition to HLA-B27, a relationship with HLA-B48 was suggested | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Ankylosing spondylitis | |
| 650 | 4 | |a HLA-B27 | |
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| 700 | 1 | |a Taniguchi, Yoshinori |e verfasserin |4 aut | |
| 700 | 1 | |a Shuto, Toshihide |e verfasserin |4 aut | |
| 700 | 1 | |a Hagimori, Kohei |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Eri |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Hisashi |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Shigeto |e verfasserin |4 aut | |
| 700 | 1 | |a Ymaji, Ken |e verfasserin |4 aut | |
| 700 | 1 | |a Tamura, Naoto |e verfasserin |4 aut | |
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