Genomic epidemiology of SARS-CoV-2 under an elimination strategy in Hong Kong
© 2022. The Author(s)..
Hong Kong employed a strategy of intermittent public health and social measures alongside increasingly stringent travel regulations to eliminate domestic SARS-CoV-2 transmission. By analyzing 1899 genome sequences (>18% of confirmed cases) from 23-January-2020 to 26-January-2021, we reveal the effects of fluctuating control measures on the evolution and epidemiology of SARS-CoV-2 lineages in Hong Kong. Despite numerous importations, only three introductions were responsible for 90% of locally-acquired cases. Community outbreaks were caused by novel introductions rather than a resurgence of circulating strains. Thus, local outbreak prevention requires strong border control and community surveillance, especially during periods of less stringent social restriction. Non-adherence to prolonged preventative measures may explain sustained local transmission observed during wave four in late 2020 and early 2021. We also found that, due to a tight transmission bottleneck, transmission of low-frequency single nucleotide variants between hosts is rare.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Nature communications - 13(2022), 1 vom: 08. Feb., Seite 736 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gu, Haogao [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 17.02.2022 Date Revised 19.04.2022 published: Electronic UpdateOf: medRxiv. 2021 Jun 23;:. - PMID 34189537 Citation Status MEDLINE |
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| doi: |
10.1038/s41467-022-28420-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a UpdateOf: medRxiv. 2021 Jun 23;:. - PMID 34189537 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a Hong Kong employed a strategy of intermittent public health and social measures alongside increasingly stringent travel regulations to eliminate domestic SARS-CoV-2 transmission. By analyzing 1899 genome sequences (>18% of confirmed cases) from 23-January-2020 to 26-January-2021, we reveal the effects of fluctuating control measures on the evolution and epidemiology of SARS-CoV-2 lineages in Hong Kong. Despite numerous importations, only three introductions were responsible for 90% of locally-acquired cases. Community outbreaks were caused by novel introductions rather than a resurgence of circulating strains. Thus, local outbreak prevention requires strong border control and community surveillance, especially during periods of less stringent social restriction. Non-adherence to prolonged preventative measures may explain sustained local transmission observed during wave four in late 2020 and early 2021. We also found that, due to a tight transmission bottleneck, transmission of low-frequency single nucleotide variants between hosts is rare | ||
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| 700 | 1 | |a Xie, Ruopeng |e verfasserin |4 aut | |
| 700 | 1 | |a Adam, Dillon C |e verfasserin |4 aut | |
| 700 | 1 | |a Tsui, Joseph L-H |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Daniel K |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Lydia D J |e verfasserin |4 aut | |
| 700 | 1 | |a Cheuk, Sammi S Y |e verfasserin |4 aut | |
| 700 | 1 | |a Gurung, Shreya |e verfasserin |4 aut | |
| 700 | 1 | |a Krishnan, Pavithra |e verfasserin |4 aut | |
| 700 | 1 | |a Ng, Daisy Y M |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Gigi Y Z |e verfasserin |4 aut | |
| 700 | 1 | |a Wan, Carrie K C |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Samuel S M |e verfasserin |4 aut | |
| 700 | 1 | |a Edwards, Kimberly M |e verfasserin |4 aut | |
| 700 | 1 | |a Leung, Kathy S M |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Joseph T |e verfasserin |4 aut | |
| 700 | 1 | |a Tsang, Dominic N C |e verfasserin |4 aut | |
| 700 | 1 | |a Leung, Gabriel M |e verfasserin |4 aut | |
| 700 | 1 | |a Cowling, Benjamin J |e verfasserin |4 aut | |
| 700 | 1 | |a Peiris, Malik |e verfasserin |4 aut | |
| 700 | 1 | |a Lam, Tommy T Y |e verfasserin |4 aut | |
| 700 | 1 | |a Dhanasekaran, Vijaykrishna |e verfasserin |4 aut | |
| 700 | 1 | |a Poon, Leo L M |e verfasserin |4 aut | |
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