Association of gut-related metabolites with respiratory symptoms in COVID-19 : A proof-of-concept study
Copyright © 2022 Elsevier Inc. All rights reserved..
Gut-related metabolites have been linked with respiratory disease. The crosstalk between the gut and lungs suggests that gut health may be compromised in COVID-19. The aims of the present study were to analyze a panel of gut-related metabolites (acetyl-L-carnitine, betaine, choline, L-carnitine, trimethylamine, and trimethylamine N-oxide) in patients with COVID-19, matched with healthy individuals and patients with non-COVID-19 respiratory symptoms. As results, metabolites from this panel were impaired in patients with COVID-19 and were associated with the symptoms of breathlessness and temperature, and it was possible to differentiate between COVID-19 and asthma. Preliminary results showed that lower levels of betaine appeared to be associated with poor outcomes in patients with COVID-19, suggesting betaine as a marker of gut microbiome health.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:96 |
|---|---|
| Enthalten in: |
Nutrition (Burbank, Los Angeles County, Calif.) - 96(2022) vom: 11. Apr., Seite 111585 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Israr, Muhammad Zubair [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
3SCV180C9W |
|---|
| Anmerkungen: |
Date Completed 17.03.2022 Date Revised 14.02.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.nut.2021.111585 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM336640528 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM336640528 | ||
| 003 | DE-627 | ||
| 005 | 20240214232422.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.nut.2021.111585 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1292.xml |
| 035 | |a (DE-627)NLM336640528 | ||
| 035 | |a (NLM)35131599 | ||
| 035 | |a (PII)S0899-9007(21)00447-0 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Israr, Muhammad Zubair |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association of gut-related metabolites with respiratory symptoms in COVID-19 |b A proof-of-concept study |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 17.03.2022 | ||
| 500 | |a Date Revised 14.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a Gut-related metabolites have been linked with respiratory disease. The crosstalk between the gut and lungs suggests that gut health may be compromised in COVID-19. The aims of the present study were to analyze a panel of gut-related metabolites (acetyl-L-carnitine, betaine, choline, L-carnitine, trimethylamine, and trimethylamine N-oxide) in patients with COVID-19, matched with healthy individuals and patients with non-COVID-19 respiratory symptoms. As results, metabolites from this panel were impaired in patients with COVID-19 and were associated with the symptoms of breathlessness and temperature, and it was possible to differentiate between COVID-19 and asthma. Preliminary results showed that lower levels of betaine appeared to be associated with poor outcomes in patients with COVID-19, suggesting betaine as a marker of gut microbiome health | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Gut microbiota | |
| 650 | 4 | |a Metabolomics | |
| 650 | 4 | |a Respiratory | |
| 650 | 7 | |a Methylamines |2 NLM | |
| 650 | 7 | |a Betaine |2 NLM | |
| 650 | 7 | |a 3SCV180C9W |2 NLM | |
| 650 | 7 | |a Choline |2 NLM | |
| 650 | 7 | |a N91BDP6H0X |2 NLM | |
| 650 | 7 | |a Carnitine |2 NLM | |
| 650 | 7 | |a S7UI8SM58A |2 NLM | |
| 700 | 1 | |a Ibrahim, Wadah |e verfasserin |4 aut | |
| 700 | 1 | |a Salzano, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Sarmad, Sarir |e verfasserin |4 aut | |
| 700 | 1 | |a Wilde, Michael J |e verfasserin |4 aut | |
| 700 | 1 | |a Cordell, Rebecca L |e verfasserin |4 aut | |
| 700 | 1 | |a Greening, Neil J |e verfasserin |4 aut | |
| 700 | 1 | |a Brightling, Christopher E |e verfasserin |4 aut | |
| 700 | 1 | |a Siddiqui, Salman |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Toru |e verfasserin |4 aut | |
| 700 | 0 | |a EMBER consortium |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nutrition (Burbank, Los Angeles County, Calif.) |d 1989 |g 96(2022) vom: 11. Apr., Seite 111585 |w (DE-627)NLM012951811 |x 1873-1244 |7 nnns |
| 773 | 1 | 8 | |g volume:96 |g year:2022 |g day:11 |g month:04 |g pages:111585 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.nut.2021.111585 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 96 |j 2022 |b 11 |c 04 |h 111585 | ||