Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved..
Although the neurogenesis-enhancing effects of exercise have been extensively studied, the molecular mechanisms underlying this response remain unclear. Here, we propose that this is mediated by the exercise-induced systemic release of the antioxidant selenium transport protein, selenoprotein P (SEPP1). Using knockout mouse models, we confirmed that SEPP1 and its receptor low-density lipoprotein receptor-related protein 8 (LRP8) are required for the exercise-induced increase in adult hippocampal neurogenesis. In vivo selenium infusion increased hippocampal neural precursor cell (NPC) proliferation and adult neurogenesis. Mimicking the effect of exercise through dietary selenium supplementation restored neurogenesis and reversed the cognitive decline associated with aging and hippocampal injury, suggesting potential therapeutic relevance. These results provide a molecular mechanism linking exercise-induced changes in the systemic environment to the activation of quiescent hippocampal NPCs and their subsequent recruitment into the neurogenic trajectory.
| Errataetall: |
ErratumIn: Cell Metab. 2023 Jun 6;35(6):1085. - PMID 37285804 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Cell metabolism - 34(2022), 3 vom: 01. März, Seite 408-423.e8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Leiter, Odette [VerfasserIn] |
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| Links: |
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| Themen: |
Adult neurogenesis |
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| Anmerkungen: |
Date Completed 04.05.2022 Date Revised 07.06.2023 published: Print-Electronic ErratumIn: Cell Metab. 2023 Jun 6;35(6):1085. - PMID 37285804 Citation Status MEDLINE |
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| doi: |
10.1016/j.cmet.2022.01.005 |
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| 500 | |a ErratumIn: Cell Metab. 2023 Jun 6;35(6):1085. - PMID 37285804 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Although the neurogenesis-enhancing effects of exercise have been extensively studied, the molecular mechanisms underlying this response remain unclear. Here, we propose that this is mediated by the exercise-induced systemic release of the antioxidant selenium transport protein, selenoprotein P (SEPP1). Using knockout mouse models, we confirmed that SEPP1 and its receptor low-density lipoprotein receptor-related protein 8 (LRP8) are required for the exercise-induced increase in adult hippocampal neurogenesis. In vivo selenium infusion increased hippocampal neural precursor cell (NPC) proliferation and adult neurogenesis. Mimicking the effect of exercise through dietary selenium supplementation restored neurogenesis and reversed the cognitive decline associated with aging and hippocampal injury, suggesting potential therapeutic relevance. These results provide a molecular mechanism linking exercise-induced changes in the systemic environment to the activation of quiescent hippocampal NPCs and their subsequent recruitment into the neurogenic trajectory | ||
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| 700 | 1 | |a Grönnert, Lisa |e verfasserin |4 aut | |
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| 700 | 1 | |a Overall, Rupert W |e verfasserin |4 aut | |
| 700 | 1 | |a Adusumilli, Vijay S |e verfasserin |4 aut | |
| 700 | 1 | |a Blackmore, Daniel G |e verfasserin |4 aut | |
| 700 | 1 | |a Southon, Adam |e verfasserin |4 aut | |
| 700 | 1 | |a Ganio, Katherine |e verfasserin |4 aut | |
| 700 | 1 | |a McDevitt, Christopher A |e verfasserin |4 aut | |
| 700 | 1 | |a Rund, Nicole |e verfasserin |4 aut | |
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| 700 | 1 | |a Kempermann, Gerd |e verfasserin |4 aut | |
| 700 | 1 | |a Walker, Tara L |e verfasserin |4 aut | |
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