Outcomes of lung transplantation from organ donation after medical assistance in dying : First North American experience
© 2022 The American Society of Transplantation and the American Society of Transplant Surgeons..
Over 2.5% of deaths in Canada occur as a result from medical assisting in dying (MAID), and a subset of these deaths result in organ donation. However, detailed outcomes of lung transplant recipients using these donors is lacking. This is a retrospective single center cohort study comparing lung transplantation outcomes after donation using MAID donors compared to neurologically determined death and controlled donation after circulatory death (NDD/cDCD) donors from February 2018 to July 2021. Thirty-three patients received lungs from MAID donors, and 560 patients received lungs from NDD/cDCD donors. The donor diagnoses leading to MAID provision were degenerative neurological diseases (n = 33) and end stage organ failure (n = 5). MAID donors were significantly older than NDD/cDCD donors (56 [IQR 49-64] years vs. 48 [32-59]; p = .0009). Median ventilation period and 30 day mortality were not significantly different between MAID and NDD/cDCD lungs recipients (ventilation: 1 day [1-3] vs 2 days [1-3]; p = .37, deaths 0% [0/33] vs. 2% [11/560], p = .99 respectively). Intermediate-term outcomes were also similar. In summary, for lung transplantation using donors after MAID, recipient outcomes were excellent. Therefore, where this practice is permitted, donation after MAID should be strongly considered for lung transplantation as a way to respect donor wishes while substantially improving outcomes for recipients with end-stage lung disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 22(2022), 6 vom: 04. Juni, Seite 1637-1645 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Watanabe, Tatsuaki [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 09.06.2022 Date Revised 24.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/ajt.16971 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM336419872 |
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| 520 | |a Over 2.5% of deaths in Canada occur as a result from medical assisting in dying (MAID), and a subset of these deaths result in organ donation. However, detailed outcomes of lung transplant recipients using these donors is lacking. This is a retrospective single center cohort study comparing lung transplantation outcomes after donation using MAID donors compared to neurologically determined death and controlled donation after circulatory death (NDD/cDCD) donors from February 2018 to July 2021. Thirty-three patients received lungs from MAID donors, and 560 patients received lungs from NDD/cDCD donors. The donor diagnoses leading to MAID provision were degenerative neurological diseases (n = 33) and end stage organ failure (n = 5). MAID donors were significantly older than NDD/cDCD donors (56 [IQR 49-64] years vs. 48 [32-59]; p = .0009). Median ventilation period and 30 day mortality were not significantly different between MAID and NDD/cDCD lungs recipients (ventilation: 1 day [1-3] vs 2 days [1-3]; p = .37, deaths 0% [0/33] vs. 2% [11/560], p = .99 respectively). Intermediate-term outcomes were also similar. In summary, for lung transplantation using donors after MAID, recipient outcomes were excellent. Therefore, where this practice is permitted, donation after MAID should be strongly considered for lung transplantation as a way to respect donor wishes while substantially improving outcomes for recipients with end-stage lung disease | ||
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| 650 | 4 | |a clinical research/practice | |
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| 650 | 4 | |a donors and donation: donation after circulatory death (DCD) | |
| 650 | 4 | |a donors and donation: extended criteria | |
| 650 | 4 | |a lung transplantation/pulmonology | |
| 650 | 4 | |a organ procurement | |
| 650 | 4 | |a organ transplantation in general | |
| 700 | 1 | |a Kawashima, Mitsuaki |e verfasserin |4 aut | |
| 700 | 1 | |a Kohno, Mikihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yeung, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Downar, James |e verfasserin |4 aut | |
| 700 | 1 | |a Healey, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Martinu, Tereza |e verfasserin |4 aut | |
| 700 | 1 | |a Aversa, Meghan |e verfasserin |4 aut | |
| 700 | 1 | |a Donahoe, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Pierre, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a de Perrot, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Yasufuku, Kazuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Waddell, Thomas K |e verfasserin |4 aut | |
| 700 | 1 | |a Keshavjee, Shaf |e verfasserin |4 aut | |
| 700 | 1 | |a Cypel, Marcelo |e verfasserin |4 aut | |
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