Diagnosis and risk factors for intracranial aneurysms in autosomal polycystic kidney disease : a cross-sectional study from the Genkyst cohort
© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA..
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is associated with an increased risk for developing intracranial aneurysms (IAs). We aimed to evaluate the frequency of diagnosis of IAs in the cross-sectional, population-based, Genkyst cohort, to describe ADPKD-associated IAs and to analyse the risk factors associated with the occurrence of IAs in ADPKD patients.
METHODS: A cross-sectional study was performed in 26 nephrology centres from the western part of France. All patients underwent genetic testing for PKD1/PKD2 and other cystogenes.
RESULTS: Among the 2449 Genkyst participants, 114 (4.65%) had a previous diagnosis of ruptured or unruptured IAs at inclusion, and ∼47% of them had a positive familial history for IAs. Most aneurysms were small and saccular and located in the anterior circulation; 26.3% of the patients had multiple IAs. The cumulative probabilities of a previous diagnosis of IAs were 3.9%, 6.2% and 8.1% at 50, 60 and 70 years, respectively. While this risk appeared to be similar in male and female individuals <50 years, after that age, the risk continued to increase more markedly in female patients, reaching 10.8% versus 5.4% at 70 years. The diagnosis rate of IAs was >2-fold higher in PKD1 compared with PKD2, with no influence of PKD1 mutation type or location. In multivariate analysis, female sex, hypertension <35 years, smoking and PKD1 genotype were associated with an increased risk for diagnosis of IAs.
CONCLUSIONS: This study presents epidemiological data reflecting real-life clinical practice. The increased risk for IAs in postmenopausal women suggests a possible protective role of oestrogen.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
|---|---|
| Enthalten in: |
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 37(2022), 11 vom: 19. Okt., Seite 2223-2233 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lefèvre, Siriane [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Autosomal dominant polycystic kidney disease (ADPKD) |
|---|
| Anmerkungen: |
Date Completed 24.10.2022 Date Revised 17.11.2022 published: Print ClinicalTrials.gov: NCT02112136 Citation Status MEDLINE |
|---|
| doi: |
10.1093/ndt/gfac027 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM336419384 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM336419384 | ||
| 003 | DE-627 | ||
| 005 | 20231225232114.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/ndt/gfac027 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1121.xml |
| 035 | |a (DE-627)NLM336419384 | ||
| 035 | |a (NLM)35108395 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lefèvre, Siriane |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Diagnosis and risk factors for intracranial aneurysms in autosomal polycystic kidney disease |b a cross-sectional study from the Genkyst cohort |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 24.10.2022 | ||
| 500 | |a Date Revised 17.11.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a ClinicalTrials.gov: NCT02112136 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of the ERA. | ||
| 520 | |a BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is associated with an increased risk for developing intracranial aneurysms (IAs). We aimed to evaluate the frequency of diagnosis of IAs in the cross-sectional, population-based, Genkyst cohort, to describe ADPKD-associated IAs and to analyse the risk factors associated with the occurrence of IAs in ADPKD patients | ||
| 520 | |a METHODS: A cross-sectional study was performed in 26 nephrology centres from the western part of France. All patients underwent genetic testing for PKD1/PKD2 and other cystogenes | ||
| 520 | |a RESULTS: Among the 2449 Genkyst participants, 114 (4.65%) had a previous diagnosis of ruptured or unruptured IAs at inclusion, and ∼47% of them had a positive familial history for IAs. Most aneurysms were small and saccular and located in the anterior circulation; 26.3% of the patients had multiple IAs. The cumulative probabilities of a previous diagnosis of IAs were 3.9%, 6.2% and 8.1% at 50, 60 and 70 years, respectively. While this risk appeared to be similar in male and female individuals <50 years, after that age, the risk continued to increase more markedly in female patients, reaching 10.8% versus 5.4% at 70 years. The diagnosis rate of IAs was >2-fold higher in PKD1 compared with PKD2, with no influence of PKD1 mutation type or location. In multivariate analysis, female sex, hypertension <35 years, smoking and PKD1 genotype were associated with an increased risk for diagnosis of IAs | ||
| 520 | |a CONCLUSIONS: This study presents epidemiological data reflecting real-life clinical practice. The increased risk for IAs in postmenopausal women suggests a possible protective role of oestrogen | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a autosomal dominant polycystic kidney disease (ADPKD) | |
| 650 | 4 | |a genetics | |
| 650 | 4 | |a intracranial aneurysms | |
| 650 | 4 | |a risk factors | |
| 650 | 4 | |a subarachnoid haemorrhage | |
| 650 | 7 | |a Estrogens |2 NLM | |
| 700 | 1 | |a Audrézet, Marie-Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Halimi, Jean-Michel |e verfasserin |4 aut | |
| 700 | 1 | |a Longuet, Hélène |e verfasserin |4 aut | |
| 700 | 1 | |a Bridoux, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Ecotière, Laure |e verfasserin |4 aut | |
| 700 | 1 | |a Augusto, Jean-François |e verfasserin |4 aut | |
| 700 | 1 | |a Duveau, Agnès |e verfasserin |4 aut | |
| 700 | 1 | |a Renaudineau, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Vigneau, Cécile |e verfasserin |4 aut | |
| 700 | 1 | |a Frouget, Thierry |e verfasserin |4 aut | |
| 700 | 1 | |a Charasse, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Gueguen, Lorraine |e verfasserin |4 aut | |
| 700 | 1 | |a Perrichot, Régine |e verfasserin |4 aut | |
| 700 | 1 | |a Couvrat, Grégoire |e verfasserin |4 aut | |
| 700 | 1 | |a Seret, Guillaume |e verfasserin |4 aut | |
| 700 | 1 | |a Le Meur, Yannick |e verfasserin |4 aut | |
| 700 | 1 | |a Cornec-Le Gall, Emilie |e verfasserin |4 aut | |
| 700 | 0 | |a Genkyst Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Grall-Jezequel, Drs A |e investigator |4 oth | |
| 700 | 1 | |a Moal, M C |e investigator |4 oth | |
| 700 | 1 | |a Hanrotel-Saliou, C |e investigator |4 oth | |
| 700 | 1 | |a Segalen, I |e investigator |4 oth | |
| 700 | 1 | |a Tanquerel, T |e investigator |4 oth | |
| 700 | 1 | |a Lanfranco, L |e investigator |4 oth | |
| 700 | 1 | |a Huynh, V T |e investigator |4 oth | |
| 700 | 1 | |a Capdeville, A |e investigator |4 oth | |
| 700 | 1 | |a Morin, M P |e investigator |4 oth | |
| 700 | 1 | |a Le Pogamp, P |e investigator |4 oth | |
| 700 | 1 | |a Gie, S |e investigator |4 oth | |
| 700 | 1 | |a Rivalan, J |e investigator |4 oth | |
| 700 | 1 | |a Laruelle, E |e investigator |4 oth | |
| 700 | 1 | |a Richer, C |e investigator |4 oth | |
| 700 | 1 | |a Lorcy, N |e investigator |4 oth | |
| 700 | 1 | |a Golbin, L |e investigator |4 oth | |
| 700 | 1 | |a Terrasse, M |e investigator |4 oth | |
| 700 | 1 | |a Morice, S |e investigator |4 oth | |
| 700 | 1 | |a Brenier, H |e investigator |4 oth | |
| 700 | 1 | |a Michel, A |e investigator |4 oth | |
| 700 | 1 | |a Lavergne, A |e investigator |4 oth | |
| 700 | 1 | |a Tomkiewicz, E |e investigator |4 oth | |
| 700 | 1 | |a Gatault, P |e investigator |4 oth | |
| 700 | 1 | |a Merieau, E |e investigator |4 oth | |
| 700 | 1 | |a Barbet, C |e investigator |4 oth | |
| 700 | 1 | |a Buchler, M |e investigator |4 oth | |
| 700 | 1 | |a Golea, G |e investigator |4 oth | |
| 700 | 1 | |a Ghouti, L |e investigator |4 oth | |
| 700 | 1 | |a Gautard, D |e investigator |4 oth | |
| 700 | 1 | |a Sautenet, B |e investigator |4 oth | |
| 700 | 1 | |a François, M |e investigator |4 oth | |
| 700 | 1 | |a Fournier, A |e investigator |4 oth | |
| 700 | 1 | |a Baron, C |e investigator |4 oth | |
| 700 | 1 | |a Salmon, C |e investigator |4 oth | |
| 700 | 1 | |a Rabot, N |e investigator |4 oth | |
| 700 | 1 | |a Prat, L |e investigator |4 oth | |
| 700 | 1 | |a Valentin, J F |e investigator |4 oth | |
| 700 | 1 | |a Birmele, B |e investigator |4 oth | |
| 700 | 1 | |a Genest, C |e investigator |4 oth | |
| 700 | 1 | |a Goumard, A |e investigator |4 oth | |
| 700 | 1 | |a Desport, E |e investigator |4 oth | |
| 700 | 1 | |a Thierry, A |e investigator |4 oth | |
| 700 | 1 | |a Touchard, G |e investigator |4 oth | |
| 700 | 1 | |a Belmouaz, M |e investigator |4 oth | |
| 700 | 1 | |a Javaugue, V |e investigator |4 oth | |
| 700 | 1 | |a Bauwens, M A |e investigator |4 oth | |
| 700 | 1 | |a Fride-Leroy, F |e investigator |4 oth | |
| 700 | 1 | |a Bouteau, I |e investigator |4 oth | |
| 700 | 1 | |a Subra, J F |e investigator |4 oth | |
| 700 | 1 | |a Besson, V |e investigator |4 oth | |
| 700 | 1 | |a Cousin, M |e investigator |4 oth | |
| 700 | 1 | |a Sayegh, J |e investigator |4 oth | |
| 700 | 1 | |a Onno, C |e investigator |4 oth | |
| 700 | 1 | |a Maghakian, M N |e investigator |4 oth | |
| 700 | 1 | |a Demiselle, J |e investigator |4 oth | |
| 700 | 1 | |a Garnier, A S |e investigator |4 oth | |
| 700 | 1 | |a Planchais, M |e investigator |4 oth | |
| 700 | 1 | |a Guibert, F |e investigator |4 oth | |
| 700 | 1 | |a Stanescu, C |e investigator |4 oth | |
| 700 | 1 | |a Le Cacheux, P |e investigator |4 oth | |
| 700 | 1 | |a Baluta, S |e investigator |4 oth | |
| 700 | 1 | |a Leonetti, F |e investigator |4 oth | |
| 700 | 1 | |a Boulahrouz, R |e investigator |4 oth | |
| 700 | 1 | |a Ferrier, M L |e investigator |4 oth | |
| 700 | 1 | |a Freguin, C |e investigator |4 oth | |
| 700 | 1 | |a Simon, A |e investigator |4 oth | |
| 700 | 1 | |a Potier, J |e investigator |4 oth | |
| 700 | 1 | |a Coulibaly, J M |e investigator |4 oth | |
| 700 | 1 | |a Colombo, A |e investigator |4 oth | |
| 700 | 1 | |a Dolley-Hitze, T |e investigator |4 oth | |
| 700 | 1 | |a Michez, E |e investigator |4 oth | |
| 700 | 1 | |a Mandart, L |e investigator |4 oth | |
| 700 | 1 | |a Menoyo, V |e investigator |4 oth | |
| 700 | 1 | |a Pincon, E |e investigator |4 oth | |
| 700 | 1 | |a Muresan, C |e investigator |4 oth | |
| 700 | 1 | |a Durand, P Y |e investigator |4 oth | |
| 700 | 1 | |a Wegner, I |e investigator |4 oth | |
| 700 | 1 | |a Metes, I |e investigator |4 oth | |
| 700 | 1 | |a Guyon-Roger, T |e investigator |4 oth | |
| 700 | 1 | |a Wehbe, B |e investigator |4 oth | |
| 700 | 1 | |a Siohan, P |e investigator |4 oth | |
| 700 | 1 | |a Drouet, C |e investigator |4 oth | |
| 700 | 1 | |a Le Guillou, A |e investigator |4 oth | |
| 700 | 1 | |a Le Jeune, M |e investigator |4 oth | |
| 700 | 1 | |a Beillard, G |e investigator |4 oth | |
| 700 | 1 | |a Corlu, L |e investigator |4 oth | |
| 700 | 1 | |a Sawadogo, T |e investigator |4 oth | |
| 700 | 1 | |a Georgescu, S |e investigator |4 oth | |
| 700 | 1 | |a Jousset, P |e investigator |4 oth | |
| 700 | 1 | |a Latif, R |e investigator |4 oth | |
| 700 | 1 | |a Massad, M |e investigator |4 oth | |
| 700 | 1 | |a Jaulin, J P |e investigator |4 oth | |
| 700 | 1 | |a Couvrat-Desvergnes, G |e investigator |4 oth | |
| 700 | 1 | |a Querard, A H |e investigator |4 oth | |
| 700 | 1 | |a Ottavioli, J N |e investigator |4 oth | |
| 700 | 1 | |a Target, N |e investigator |4 oth | |
| 700 | 1 | |a Chapal, A |e investigator |4 oth | |
| 700 | 1 | |a Le Fur, A |e investigator |4 oth | |
| 700 | 1 | |a Besnier, D |e investigator |4 oth | |
| 700 | 1 | |a Coz, S Regnier-Le |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association |d 1990 |g 37(2022), 11 vom: 19. Okt., Seite 2223-2233 |w (DE-627)NLM012639206 |x 1460-2385 |7 nnns |
| 773 | 1 | 8 | |g volume:37 |g year:2022 |g number:11 |g day:19 |g month:10 |g pages:2223-2233 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/ndt/gfac027 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 37 |j 2022 |e 11 |b 19 |c 10 |h 2223-2233 | ||