The association between glucocorticoid receptor (NR3C1) gene polymorphism and difficult-to-treat rhinosinusitis
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
BACKGROUND: Difficult-to-treat rhinosinusitis (DTRS) seriously affects the quality of work and life of patients, and the cause is still unclear. We aimed to explore the association between the glucocorticoid receptor (NR3C1) gene polymorphisms and DTRS.
METHODS: A nested case-control study was conducted. The exons of NR3C1 gene were sequenced by an ABI 9700 DNA analyzer in 30 DTRS patients and 70 matched chronic rhinosinusitis (CRS) patient with good outcome (non-DTRS). The genotypic and allele frequencies were calculated and linkage disequilibrium was analyzed.
RESULTS: The three SNPs showed a significant difference between the DTRS and non-DTRS groups. In allelic model analysis, we found that the allele "C" of rs6196, the allele "A" of rs258751, and the allele "T" of rs6194 were associated with increased the risk of DTRS (all p < 0.05). In addition, the haplotype CAT of the 3 SNPs was detected to be significantly associated with DTRS risk (p = 0.001), while the haplotype TGC was associated with the decreased risk of DTRS (p = 0.008).
CONCLUSION: NR3C1 gene polymorphisms are significantly associated with the DTRS.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:279 |
|---|---|
| Enthalten in: |
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 279(2022), 8 vom: 01. Aug., Seite 3981-3987 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wu, Chan [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Chronic rhinosinusitis |
|---|
| Anmerkungen: |
Date Completed 06.07.2022 Date Revised 07.07.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00405-021-07228-z |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM336284004 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM336284004 | ||
| 003 | DE-627 | ||
| 005 | 20231225231806.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00405-021-07228-z |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1120.xml |
| 035 | |a (DE-627)NLM336284004 | ||
| 035 | |a (NLM)35094121 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wu, Chan |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The association between glucocorticoid receptor (NR3C1) gene polymorphism and difficult-to-treat rhinosinusitis |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.07.2022 | ||
| 500 | |a Date Revised 07.07.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a BACKGROUND: Difficult-to-treat rhinosinusitis (DTRS) seriously affects the quality of work and life of patients, and the cause is still unclear. We aimed to explore the association between the glucocorticoid receptor (NR3C1) gene polymorphisms and DTRS | ||
| 520 | |a METHODS: A nested case-control study was conducted. The exons of NR3C1 gene were sequenced by an ABI 9700 DNA analyzer in 30 DTRS patients and 70 matched chronic rhinosinusitis (CRS) patient with good outcome (non-DTRS). The genotypic and allele frequencies were calculated and linkage disequilibrium was analyzed | ||
| 520 | |a RESULTS: The three SNPs showed a significant difference between the DTRS and non-DTRS groups. In allelic model analysis, we found that the allele "C" of rs6196, the allele "A" of rs258751, and the allele "T" of rs6194 were associated with increased the risk of DTRS (all p < 0.05). In addition, the haplotype CAT of the 3 SNPs was detected to be significantly associated with DTRS risk (p = 0.001), while the haplotype TGC was associated with the decreased risk of DTRS (p = 0.008) | ||
| 520 | |a CONCLUSION: NR3C1 gene polymorphisms are significantly associated with the DTRS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chronic rhinosinusitis | |
| 650 | 4 | |a Difficult-to-treat rhinosinusitis | |
| 650 | 4 | |a Glucocorticoid resistance | |
| 650 | 4 | |a NR3C1 | |
| 650 | 4 | |a SNP | |
| 650 | 7 | |a NR3C1 protein, human |2 NLM | |
| 650 | 7 | |a Receptors, Glucocorticoid |2 NLM | |
| 700 | 1 | |a Fang, Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhan, Xiaojun |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Yongxiang |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery |d 1994 |g 279(2022), 8 vom: 01. Aug., Seite 3981-3987 |w (DE-627)NLM012637548 |x 1434-4726 |7 nnns |
| 773 | 1 | 8 | |g volume:279 |g year:2022 |g number:8 |g day:01 |g month:08 |g pages:3981-3987 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00405-021-07228-z |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 279 |j 2022 |e 8 |b 01 |c 08 |h 3981-3987 | ||