Combination Therapy of Stem Cell-derived Exosomes and Biomaterials in the Wound Healing

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..

Wound healing is a serious obstacle due to the complexity of evaluation and management. While novel approaches to promoting chronic wound healing are of critical interest at the moment, several studies have demonstrated that combination therapy is critical for the treatment of a variety of diseases, particularly chronic wounds. Among the various approaches that have been proposed for wound care, regenerative medicine-based methods have garnered the most attention. As is well known, regenerative medicine's three primary tools are gene/cell therapy, biomaterials, and tissue engineering. Multifunctional biomaterials composed of synthetic and natural components are highly advantageous for exosome carriers, which utilizing them is an exciting wound healing method. Recently, stem cell-secreted exosomes and certain biomaterials have been identified as critical components of the wound healing process, and their combination therapy appears to produce significant results. This paper presents a review of literature and perspectives on the use of stem cell-derived exosomes and biomaterials in wound healing, particularly chronic wounds, and discusses the possibility of future clinical applications.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:18

Enthalten in:

Stem cell reviews and reports - 18(2022), 6 vom: 26. Aug., Seite 1892-1911

Sprache:

Englisch

Beteiligte Personen:

Golchin, Ali [VerfasserIn]
Shams, Forough [VerfasserIn]
Basiri, Arefeh [VerfasserIn]
Ranjbarvan, Parviz [VerfasserIn]
Kiani, Samaneh [VerfasserIn]
Sarkhosh-Inanlou, Roya [VerfasserIn]
Ardeshirylajimi, Abdolreza [VerfasserIn]
Gholizadeh-Ghaleh Aziz, Shiva [VerfasserIn]
Sadigh, Sanaz [VerfasserIn]
Rasmi, Yousef [VerfasserIn]

Links:

Volltext

Themen:

Biocompatible Materials
Biomaterial
Exosome
Journal Article
Regenerative medicine
Review
Stem cell
Wound healing

Anmerkungen:

Date Completed 23.08.2022

Date Revised 29.08.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s12015-021-10309-5

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM336151683