Allergic rhinitis, microbiota and passive smoke in children : A pilot study
© 2022 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd..
BACKGROUND: Allergic rhinitis (AR) is one of the most common allergic diseases affecting children. Objective assessment of nasal obstruction is possible through active anterior rhinomanometry (AAR). Several factors, such as passive smoke exposure (PSE), are triggers for worsening nasal obstruction and chronic inflammation. PSE affects bacterial eubiosis in the upper respiratory tract. This study evaluates the influence of PSE and cotinine levels on both nasal obstruction and local microbiome composition in children with AR.
METHODS: Fifty patients (aged between 6 and 16 years) with AR monosensitized grass pollen were enrolled. They underwent skin prick tests, a nasal swab to evaluate the microbial composition of the anterior nostrils, a basal AAR, a post-decongestion AAR, and spirometry. Serum cotinine levels were assessed to evaluate PSE.
RESULTS: A significantly lower percentage of mean nasal flow (mNF%) was observed before and after hydrazine administration in subjects exposed to passive smoke (Exp group) compared with the non-exposed group. In contrast, higher cotinine levels were observed in the Exp group than in the controls. PSE has been associated with a decrease in biodiversity and a change in the nasal microbiome composition; instead, although to a different extent, the abundance of specific taxa resulted in being correlated to cotinine levels and nasal flow.
CONCLUSION: Children with AR exposed to passive smoke with positive serum cotinine could represent a risk factor for developing nasal obstruction and microbial dysbiosis, suggesting their possible role in pathophysiological processes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 Suppl 27 |
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| Enthalten in: |
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 33 Suppl 27(2022) vom: 22. Jan., Seite 22-26 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Brindisi, Giulia [VerfasserIn] |
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| Links: |
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| Themen: |
Allergic rhinitis |
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| Anmerkungen: |
Date Completed 31.03.2022 Date Revised 29.07.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1111/pai.13621 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM336147341 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: Allergic rhinitis (AR) is one of the most common allergic diseases affecting children. Objective assessment of nasal obstruction is possible through active anterior rhinomanometry (AAR). Several factors, such as passive smoke exposure (PSE), are triggers for worsening nasal obstruction and chronic inflammation. PSE affects bacterial eubiosis in the upper respiratory tract. This study evaluates the influence of PSE and cotinine levels on both nasal obstruction and local microbiome composition in children with AR | ||
| 520 | |a METHODS: Fifty patients (aged between 6 and 16 years) with AR monosensitized grass pollen were enrolled. They underwent skin prick tests, a nasal swab to evaluate the microbial composition of the anterior nostrils, a basal AAR, a post-decongestion AAR, and spirometry. Serum cotinine levels were assessed to evaluate PSE | ||
| 520 | |a RESULTS: A significantly lower percentage of mean nasal flow (mNF%) was observed before and after hydrazine administration in subjects exposed to passive smoke (Exp group) compared with the non-exposed group. In contrast, higher cotinine levels were observed in the Exp group than in the controls. PSE has been associated with a decrease in biodiversity and a change in the nasal microbiome composition; instead, although to a different extent, the abundance of specific taxa resulted in being correlated to cotinine levels and nasal flow | ||
| 520 | |a CONCLUSION: Children with AR exposed to passive smoke with positive serum cotinine could represent a risk factor for developing nasal obstruction and microbial dysbiosis, suggesting their possible role in pathophysiological processes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a allergic rhinitis | |
| 650 | 4 | |a children | |
| 650 | 4 | |a nasal microbiome | |
| 650 | 4 | |a passive smoke | |
| 650 | 4 | |a serum cotinine | |
| 700 | 1 | |a Marazzato, Massimiliano |e verfasserin |4 aut | |
| 700 | 1 | |a Brunetti, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a De Castro, Giovanna |e verfasserin |4 aut | |
| 700 | 1 | |a Loffredo, Lorenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Carnevale, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Cinicola, Bianca |e verfasserin |4 aut | |
| 700 | 1 | |a Palamara, Anna Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Conte, Maria Pia |e verfasserin |4 aut | |
| 700 | 1 | |a Zicari, Anna Maria |e verfasserin |4 aut | |
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