Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection
Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: To evaluate long-term sensitivity for detection of total antibodies against SARS-CoV-2 METHODS: From week 41, 2020, through week 26, 2021, all Danish blood donations were tested for SARS-CoV-2 antibodies with the Wantai assay. The results were linked with polymerase chain reaction (PCR) test results from the Danish Microbiological Database (MiBa).
RESULTS: During the study period, 105,646 non-vaccinated Danish blood donors were tested for SARS-CoV-2 antibodies, and 3,806 (3.6%) had a positive PCR test before the blood donation. Among the donors with a positive PCR test, 94.2% subsequently also had a positive antibody test. The time between the positive PCR test and the antibody test was up to 15 months and there was no evidence of a decline in proportion with detectable antibodies over time. A negative serological result test was associated with a higher incidence of re-infection (Incidence Rate Ratio = 0.102 (95% confidence interval (CI): 0.039-0.262)).
CONCLUSION: Among healthy blood donors, 94.2% developed SARS-CoV-2 antibodies after infection, and a lack of detectable antibodies was associated with re-infection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:116 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 116(2022) vom: 06. März, Seite 289-292 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hønge, Bo Langhoff [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Viral |
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| Anmerkungen: |
Date Completed 01.03.2022 Date Revised 28.09.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2022.01.041 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM336123337 |
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| 100 | 1 | |a Hønge, Bo Langhoff |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection |
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| 500 | |a Date Revised 28.09.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVES: To evaluate long-term sensitivity for detection of total antibodies against SARS-CoV-2 METHODS: From week 41, 2020, through week 26, 2021, all Danish blood donations were tested for SARS-CoV-2 antibodies with the Wantai assay. The results were linked with polymerase chain reaction (PCR) test results from the Danish Microbiological Database (MiBa) | ||
| 520 | |a RESULTS: During the study period, 105,646 non-vaccinated Danish blood donors were tested for SARS-CoV-2 antibodies, and 3,806 (3.6%) had a positive PCR test before the blood donation. Among the donors with a positive PCR test, 94.2% subsequently also had a positive antibody test. The time between the positive PCR test and the antibody test was up to 15 months and there was no evidence of a decline in proportion with detectable antibodies over time. A negative serological result test was associated with a higher incidence of re-infection (Incidence Rate Ratio = 0.102 (95% confidence interval (CI): 0.039-0.262)) | ||
| 520 | |a CONCLUSION: Among healthy blood donors, 94.2% developed SARS-CoV-2 antibodies after infection, and a lack of detectable antibodies was associated with re-infection | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a seroprevalence | |
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| 700 | 1 | |a Kaspersen, Kathrine Agergård |e verfasserin |4 aut | |
| 700 | 1 | |a Harritshøj, Lene Holm |e verfasserin |4 aut | |
| 700 | 1 | |a Mikkelsen, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a Holm, Dorte Kinggaard |e verfasserin |4 aut | |
| 700 | 1 | |a Nilsson, Anna Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Sækmose, Susanne Gjørup |e verfasserin |4 aut | |
| 700 | 1 | |a Sørensen, Erik |e verfasserin |4 aut | |
| 700 | 1 | |a Aagaard, Bitten |e verfasserin |4 aut | |
| 700 | 1 | |a Hjalgrim, Henrik |e verfasserin |4 aut | |
| 700 | 1 | |a Jørgensen, Charlotte Sværke |e verfasserin |4 aut | |
| 700 | 1 | |a Krause, Tyra Grove |e verfasserin |4 aut | |
| 700 | 1 | |a Ullum, Henrik |e verfasserin |4 aut | |
| 700 | 1 | |a Pedersen, Ole Birger Vestager |e verfasserin |4 aut | |
| 700 | 1 | |a Ostrowski, Sisse Rye |e verfasserin |4 aut | |
| 700 | 1 | |a Erikstrup, Christian |e verfasserin |4 aut | |
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