Ingestion of orange juice prevents hyperglycemia and increases plasma miR-375 expression
Copyright © 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved..
BACKGROUND & AIMS: The intake of high-fat, high-carbohydrate (HFHC) meals is associated with an increased risk of type 2 diabetes. There is evidence that the association of orange juice to a HFHC meal can modulate the expression of microRNAs (miRNAs) linked to pancreatic β-cell function such as miR-375. We evaluated the effect of a commercial orange juice intake with HFHC meal on plasma miRNAs expression in twelve healthy subjects in a crossover design study.
METHODS: Subjects ingested water, orange juice, or an isocaloric beverage along with a 1037 kcal HFHC meal. Blood glucose and miRNAs were evaluated at baseline and 1, 3, and 5 h after the intake.
RESULTS: The area under the curve (AUC) for glycemia after ingestion of HFHC + orange juice did not differ from ingestion of HPHC + glucose or HFHC + water. However, the AUC was higher in HFHC meal + glucose compared to HFHC meal + water (p = 0.034). Glucose and insulin concentrations were significantly higher in HFHC meal + glucose group after 1 h, when compared with other groups and times (p < 0.001). There was an increase in plasma miR-375 expression after 3 h of ingestion of HFHC + orange juice versus water (p = 0.026), and a decrease in plasma miR-205-5p expression after HFHC meal + glucose versus water (p = 0.023).
CONCLUSIONS: A single HFHC meal + orange juice modulated plasma miR-375 expression, which is a biomarker of pancreatic β-cell function, and contributed to preventing hyperglycemia.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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| Enthalten in: |
Clinical nutrition ESPEN - 47(2022) vom: 15. Feb., Seite 240-245 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Quintanilha, Bruna J [VerfasserIn] |
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| Links: |
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| Themen: |
Glycemia circulating miRNA |
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| Anmerkungen: |
Date Completed 30.03.2022 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.clnesp.2021.12.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND & AIMS: The intake of high-fat, high-carbohydrate (HFHC) meals is associated with an increased risk of type 2 diabetes. There is evidence that the association of orange juice to a HFHC meal can modulate the expression of microRNAs (miRNAs) linked to pancreatic β-cell function such as miR-375. We evaluated the effect of a commercial orange juice intake with HFHC meal on plasma miRNAs expression in twelve healthy subjects in a crossover design study | ||
| 520 | |a METHODS: Subjects ingested water, orange juice, or an isocaloric beverage along with a 1037 kcal HFHC meal. Blood glucose and miRNAs were evaluated at baseline and 1, 3, and 5 h after the intake | ||
| 520 | |a RESULTS: The area under the curve (AUC) for glycemia after ingestion of HFHC + orange juice did not differ from ingestion of HPHC + glucose or HFHC + water. However, the AUC was higher in HFHC meal + glucose compared to HFHC meal + water (p = 0.034). Glucose and insulin concentrations were significantly higher in HFHC meal + glucose group after 1 h, when compared with other groups and times (p < 0.001). There was an increase in plasma miR-375 expression after 3 h of ingestion of HFHC + orange juice versus water (p = 0.026), and a decrease in plasma miR-205-5p expression after HFHC meal + glucose versus water (p = 0.023) | ||
| 520 | |a CONCLUSIONS: A single HFHC meal + orange juice modulated plasma miR-375 expression, which is a biomarker of pancreatic β-cell function, and contributed to preventing hyperglycemia | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Glycemia circulating miRNA | |
| 650 | 4 | |a Orange juice | |
| 650 | 4 | |a Pancreatic beta-cell | |
| 650 | 4 | |a Western diet | |
| 650 | 7 | |a MicroRNAs |2 NLM | |
| 700 | 1 | |a Chaves, Daniela F S |e verfasserin |4 aut | |
| 700 | 1 | |a Brasili, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Corrêa, Telma A F |e verfasserin |4 aut | |
| 700 | 1 | |a Capetini, Vinícius Cooper |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Frederico Moraes |e verfasserin |4 aut | |
| 700 | 1 | |a Castro, Inar A |e verfasserin |4 aut | |
| 700 | 1 | |a Hassimotto, Neuza M A |e verfasserin |4 aut | |
| 700 | 1 | |a Rogero, Marcelo M |e verfasserin |4 aut | |
| 700 | 1 | |a Lajolo, Franco M |e verfasserin |4 aut | |
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