COVID-19 : Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonary Factors
Multi-organ failure is one of the common causes of fatal outcome in COVID-19 patients. However, the pathogenetic association of the SARS-CoV-2 viral load (VL) level with fatal dysfunctions of the lungs, liver, kidneys, heart, spleen and brain, as well as with the risk of death in COVID-19 patients remains poorly understood. SARS-CoV-2 VL in the lungs, heart, liver, kidneys, brain, spleen and lymph nodes have been measured by RT qPCR using the following formula: NSARS-CoV-2/NABL1 × 100. Dissemination of SARS-CoV-2 in 30.5% of cases was mono-organ, and in 63.9% of cases, it was multi-organ. The average SARS-CoV-2 VL in the exudative phase of diffuse alveolar damage (DAD) was 60 times higher than in the proliferative phase. The SARS-CoV-2 VL in the lungs ranged from 0 to 250,281 copies. The "pulmonary factors" of SARS-CoV-2 multi-organ dissemination are the high level of SARS-CoV-2 VL (≥4909) and the exudative phase of DAD. The frequency of SARS-CoV-2 dissemination to lymph nodes was 86.9%, heart-56.5%, spleen-52.2%, liver-47.8%, kidney-26%, and brain-13%. We found no link between the SARS-CoV-2 VL level in the liver, kidneys, and heart and the serum level of CPK, LDH, ALP, ALT, AST and Cr of COVID-19 patients. Isolated detection of SARS-CoV-2 RNA in the myocardium of COVID-19 patients who died from heart failure is possible. The pathogenesis of COVID-19-associated multi-organ failure requires further research in a larger cohort of patients.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
---|---|
Enthalten in: |
Viruses - 14(2021), 1 vom: 26. Dez. |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Odilov, Akmaljon [VerfasserIn] |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Completed 03.02.2022 Date Revised 03.02.2022 published: Electronic Citation Status MEDLINE |
---|
doi: |
10.3390/v14010039 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM335968333 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM335968333 | ||
003 | DE-627 | ||
005 | 20231225231050.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/v14010039 |2 doi | |
028 | 5 | 2 | |a pubmed24n1119.xml |
035 | |a (DE-627)NLM335968333 | ||
035 | |a (NLM)35062243 | ||
035 | |a (PII)39 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Odilov, Akmaljon |e verfasserin |4 aut | |
245 | 1 | 0 | |a COVID-19 |b Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonary Factors |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 03.02.2022 | ||
500 | |a Date Revised 03.02.2022 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Multi-organ failure is one of the common causes of fatal outcome in COVID-19 patients. However, the pathogenetic association of the SARS-CoV-2 viral load (VL) level with fatal dysfunctions of the lungs, liver, kidneys, heart, spleen and brain, as well as with the risk of death in COVID-19 patients remains poorly understood. SARS-CoV-2 VL in the lungs, heart, liver, kidneys, brain, spleen and lymph nodes have been measured by RT qPCR using the following formula: NSARS-CoV-2/NABL1 × 100. Dissemination of SARS-CoV-2 in 30.5% of cases was mono-organ, and in 63.9% of cases, it was multi-organ. The average SARS-CoV-2 VL in the exudative phase of diffuse alveolar damage (DAD) was 60 times higher than in the proliferative phase. The SARS-CoV-2 VL in the lungs ranged from 0 to 250,281 copies. The "pulmonary factors" of SARS-CoV-2 multi-organ dissemination are the high level of SARS-CoV-2 VL (≥4909) and the exudative phase of DAD. The frequency of SARS-CoV-2 dissemination to lymph nodes was 86.9%, heart-56.5%, spleen-52.2%, liver-47.8%, kidney-26%, and brain-13%. We found no link between the SARS-CoV-2 VL level in the liver, kidneys, and heart and the serum level of CPK, LDH, ALP, ALT, AST and Cr of COVID-19 patients. Isolated detection of SARS-CoV-2 RNA in the myocardium of COVID-19 patients who died from heart failure is possible. The pathogenesis of COVID-19-associated multi-organ failure requires further research in a larger cohort of patients | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a FFPE | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a multi-organ dissemination | |
650 | 4 | |a multiplex real-time polymerase chain reaction | |
650 | 4 | |a viral load | |
650 | 7 | |a RNA, Viral |2 NLM | |
650 | 7 | |a Viral Proteins |2 NLM | |
700 | 1 | |a Volkov, Alexey |e verfasserin |4 aut | |
700 | 1 | |a Abdullaev, Adhamjon |e verfasserin |4 aut | |
700 | 1 | |a Gasanova, Tatiana |e verfasserin |4 aut | |
700 | 1 | |a Lipina, Tatiana |e verfasserin |4 aut | |
700 | 1 | |a Babichenko, Igor |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Viruses |d 2009 |g 14(2021), 1 vom: 26. Dez. |w (DE-627)NLM192382764 |x 1999-4915 |7 nnns |
773 | 1 | 8 | |g volume:14 |g year:2021 |g number:1 |g day:26 |g month:12 |
856 | 4 | 0 | |u http://dx.doi.org/10.3390/v14010039 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 14 |j 2021 |e 1 |b 26 |c 12 |