Association of Two Indices of Insulin Resistance Marker with Abnormal Liver Function Tests : A Cross-Sectional Population Study in Taiwanese Adults
Background and objectives: Insulin resistance (IR) is frequently associated with chronic low-grade inflammation and has an important role as a mediator in the development of liver disease. Thus, this study aimed to explore the relationship between two indexes of IR and abnormal liver function parameters. Materials and Methods: This cross-sectional study obtained data of 41,510 men and 92,357 women aged ≥30 years from a private health screening institute in Taiwan. Two IR indexes namely triglyceride-glucose (TyG) index and triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio were used to examine their relationship to predict abnormal liver function parameters (aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP)). Results: Positive trend was shown for the association of TyG index in the highest quintile (Q5) and risk of high AST (OR = 1.45, 95% CI: 1.33-1.57), high ALT (OR = 1.85, 95% CI: 1.73-1.97), high GGT (OR = 2.04, 95% CI: 1.93-2.15), and high ALP (OR = 1.13, 95% CI: 1.07-1.19) compared with the median quintile (Q3) in the fully adjusted model. Similarly, participants in the Q5 of the TG/HDL-C ratio were associated with 1.38 (95% CI: 1.27-1.49), 1.71 (95% CI: 1.61-1.82), 1.75 (95% CI: 1.66-1.84), and 1.21 (1.16-1.27) odds for having high AST, ALT, GGT, and ALP respectively. The AUC (95% CI) value of the TyG index for predicting high AST, high ALT, and high GGT was 0.699 (0.692-0.705), 0.738 (0.734-0.742), and 0.752 (0.749-0.755), respectively. Meanwhile, the AUC (95% CI) of the TG/HDL-C ratio for predicting high AST, high ALT, and high GGT was 0.680 (0.673-0.686), 0.738 (0.734-0.742), 0.734 (0.731-0.738), respectively. Conclusions: Our study supported that the TyG index and TG/HDL-C ratio may be useful as non-invasive methods to predict the existence of impaired liver function in the early stage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
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| Enthalten in: |
Medicina (Kaunas, Lithuania) - 58(2021), 1 vom: 21. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kurniawan, Adi-Lukas [VerfasserIn] |
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| Links: |
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| Themen: |
Alanine Transaminase |
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| Anmerkungen: |
Date Completed 24.01.2022 Date Revised 31.05.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/medicina58010004 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM33590954X |
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| 245 | 1 | 0 | |a Association of Two Indices of Insulin Resistance Marker with Abnormal Liver Function Tests |b A Cross-Sectional Population Study in Taiwanese Adults |
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| 520 | |a Background and objectives: Insulin resistance (IR) is frequently associated with chronic low-grade inflammation and has an important role as a mediator in the development of liver disease. Thus, this study aimed to explore the relationship between two indexes of IR and abnormal liver function parameters. Materials and Methods: This cross-sectional study obtained data of 41,510 men and 92,357 women aged ≥30 years from a private health screening institute in Taiwan. Two IR indexes namely triglyceride-glucose (TyG) index and triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio were used to examine their relationship to predict abnormal liver function parameters (aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP)). Results: Positive trend was shown for the association of TyG index in the highest quintile (Q5) and risk of high AST (OR = 1.45, 95% CI: 1.33-1.57), high ALT (OR = 1.85, 95% CI: 1.73-1.97), high GGT (OR = 2.04, 95% CI: 1.93-2.15), and high ALP (OR = 1.13, 95% CI: 1.07-1.19) compared with the median quintile (Q3) in the fully adjusted model. Similarly, participants in the Q5 of the TG/HDL-C ratio were associated with 1.38 (95% CI: 1.27-1.49), 1.71 (95% CI: 1.61-1.82), 1.75 (95% CI: 1.66-1.84), and 1.21 (1.16-1.27) odds for having high AST, ALT, GGT, and ALP respectively. The AUC (95% CI) value of the TyG index for predicting high AST, high ALT, and high GGT was 0.699 (0.692-0.705), 0.738 (0.734-0.742), and 0.752 (0.749-0.755), respectively. Meanwhile, the AUC (95% CI) of the TG/HDL-C ratio for predicting high AST, high ALT, and high GGT was 0.680 (0.673-0.686), 0.738 (0.734-0.742), 0.734 (0.731-0.738), respectively. Conclusions: Our study supported that the TyG index and TG/HDL-C ratio may be useful as non-invasive methods to predict the existence of impaired liver function in the early stage | ||
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| 700 | 1 | |a Lee, Hsiu-An |e verfasserin |4 aut | |
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