Solid lipid nanoparticles loaded with curcumin : development and in vitro toxicity against CT26 cells
Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Nanomedicine (London, England) - 17(2022), 3 vom: 20. Feb., Seite 167-179 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ganassin, Rayane [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer |
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| Anmerkungen: |
Date Completed 03.03.2022 Date Revised 03.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2217/nnm-2021-0229 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM335834159 |
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| 520 | |a Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a da Silva, Victor Carlos Mello |e verfasserin |4 aut | |
| 700 | 1 | |a Araujo, Victor Hugo Sousa |e verfasserin |4 aut | |
| 700 | 1 | |a Tavares, Giulia Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a da Silva, Patrícia Bento |e verfasserin |4 aut | |
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| 700 | 1 | |a Porcel, Joaquin E Martínez |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues, Mosar Corrêa |e verfasserin |4 aut | |
| 700 | 1 | |a Andreozzi, Patrizia |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandes, Richard Perosa |e verfasserin |4 aut | |
| 700 | 1 | |a Fonseca-Santos, Bruno |e verfasserin |4 aut | |
| 700 | 1 | |a Moya, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Azevedo, Ricardo Bentes |e verfasserin |4 aut | |
| 700 | 1 | |a Chorilli, Marlus |e verfasserin |4 aut | |
| 700 | 1 | |a Muehlmann, Luis Alexandre |e verfasserin |4 aut | |
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