Heart failure with preserved ejection fraction : Squaring the circle between comorbidities and cardiovascular abnormalities
Copyright © 2022. Published by Elsevier B.V..
Heart Failure with preserved Ejection Fraction (HFpEF) is nowadays considered a major healthcare issue. According to forecasts two third of all Heart Failure patients will belong to this phenotype by year 2050, overwhelming those affected by Heart Failure with reduced Ejection Fraction (HFrEF). Both epidemiological and mechanistic studies support the concept that HFpEF represents true HF although aggravated by a collection of comorbidities. There is urgent need of improving its phenotyping due to the high degree of disease heterogeneity within HFpEF that lead to the failure of randomized clinical trials in demonstrating a remarkable impact of drugs in improving its morbidity and mortality.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:99 |
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| Enthalten in: |
European journal of internal medicine - 99(2022) vom: 11. Mai, Seite 1-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Marra, Alberto Maria [VerfasserIn] |
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| Links: |
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| Themen: |
Aging population |
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| Anmerkungen: |
Date Completed 27.04.2022 Date Revised 27.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejim.2022.01.019 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM33568193X |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022. Published by Elsevier B.V. | ||
| 520 | |a Heart Failure with preserved Ejection Fraction (HFpEF) is nowadays considered a major healthcare issue. According to forecasts two third of all Heart Failure patients will belong to this phenotype by year 2050, overwhelming those affected by Heart Failure with reduced Ejection Fraction (HFrEF). Both epidemiological and mechanistic studies support the concept that HFpEF represents true HF although aggravated by a collection of comorbidities. There is urgent need of improving its phenotyping due to the high degree of disease heterogeneity within HFpEF that lead to the failure of randomized clinical trials in demonstrating a remarkable impact of drugs in improving its morbidity and mortality | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cardiovascular abnormalities | |
| 650 | 4 | |a Comorbidities | |
| 650 | 4 | |a Heart failure with preserved ejection fraction | |
| 650 | 4 | |a aging population | |
| 700 | 1 | |a Bencivenga, Leonardo |e verfasserin |4 aut | |
| 700 | 1 | |a D'Assante, Roberta |e verfasserin |4 aut | |
| 700 | 1 | |a Rengo, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Cittadini, Antonio |e verfasserin |4 aut | |
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