Respiratory Syncytial Virus-Associated Hospital Admissions and Bed Days in Children <5 Years of Age in 7 European Countries
© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com..
BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections (RTIs) in young children. High-quality country-specific estimates of bed days and length of stay (LOS) show the population burden of RSV-RTI on secondary care services and the burden among patients, and can be used to inform RSV immunization implementation decisions.
METHODS: We estimated the hospital burden of RSV-associated RTI (RSV-RTI) in children under 5 years in 7 European countries (Finland, Denmark, Norway, Scotland, England, the Netherlands, and Italy) using routinely collected hospital databases during 2001-2018. We described RSV-RTI admission rates during the first year of life by birth month and assessed their correlation with RSV seasonality in 5 of the countries (except for England and Italy). We estimated average annual numbers and rates of bed days for RSV-RTI and other-pathogen RTI, as well as the hospital LOS.
RESULTS: We found that infants born 2 months before the peak month of RSV epidemics more frequently had the highest RSV-RTI hospital admission rate. RSV-RTI hospital episodes accounted for 9.9-21.2 bed days per 1000 children aged <5 years annually, with the median (interquartile range) LOS ranging from 2 days (0.5-4 days) to 4 days (2-6 days) between countries. Between 70% and 89% of these bed days were in infants aged <1 year, representing 40.3 (95% confidence interval [CI], 40.1-40.4) to 91.2 (95% CI, 90.6-91.8) bed days per 1000 infants annually. The number of bed days for RSV-RTI was higher than that for RTIs associated with other pathogens in infants aged <1 year, especially in those <6 months.
CONCLUSIONS: RSV disease prevention therapies (monoclonal antibodies and maternal vaccines) for infants could help prevent a substantial number of bed days due to RSV-RTI. "High-risk" birth months should be considered when developing RSV immunization schedules. Variation in LOS between countries might reflect differences in hospital care practices.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:226 |
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| Enthalten in: |
The Journal of infectious diseases - 226(2022), Suppl 1 vom: 12. Aug., Seite S22-S28 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Xin [VerfasserIn] |
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| Links: |
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| Themen: |
Bed days |
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| Anmerkungen: |
Date Completed 16.08.2022 Date Revised 21.08.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiab560 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM335584403 |
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| 245 | 1 | 0 | |a Respiratory Syncytial Virus-Associated Hospital Admissions and Bed Days in Children <5 Years of Age in 7 European Countries |
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| 500 | |a Date Revised 21.08.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections (RTIs) in young children. High-quality country-specific estimates of bed days and length of stay (LOS) show the population burden of RSV-RTI on secondary care services and the burden among patients, and can be used to inform RSV immunization implementation decisions | ||
| 520 | |a METHODS: We estimated the hospital burden of RSV-associated RTI (RSV-RTI) in children under 5 years in 7 European countries (Finland, Denmark, Norway, Scotland, England, the Netherlands, and Italy) using routinely collected hospital databases during 2001-2018. We described RSV-RTI admission rates during the first year of life by birth month and assessed their correlation with RSV seasonality in 5 of the countries (except for England and Italy). We estimated average annual numbers and rates of bed days for RSV-RTI and other-pathogen RTI, as well as the hospital LOS | ||
| 520 | |a RESULTS: We found that infants born 2 months before the peak month of RSV epidemics more frequently had the highest RSV-RTI hospital admission rate. RSV-RTI hospital episodes accounted for 9.9-21.2 bed days per 1000 children aged <5 years annually, with the median (interquartile range) LOS ranging from 2 days (0.5-4 days) to 4 days (2-6 days) between countries. Between 70% and 89% of these bed days were in infants aged <1 year, representing 40.3 (95% confidence interval [CI], 40.1-40.4) to 91.2 (95% CI, 90.6-91.8) bed days per 1000 infants annually. The number of bed days for RSV-RTI was higher than that for RTIs associated with other pathogens in infants aged <1 year, especially in those <6 months | ||
| 520 | |a CONCLUSIONS: RSV disease prevention therapies (monoclonal antibodies and maternal vaccines) for infants could help prevent a substantial number of bed days due to RSV-RTI. "High-risk" birth months should be considered when developing RSV immunization schedules. Variation in LOS between countries might reflect differences in hospital care practices | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Europe | |
| 650 | 4 | |a bed days | |
| 650 | 4 | |a birth month | |
| 650 | 4 | |a hospital admission | |
| 650 | 4 | |a respiratory syncytial virus | |
| 700 | 1 | |a Li, You |e verfasserin |4 aut | |
| 700 | 1 | |a Vazquez Fernandez, Liliana |e verfasserin |4 aut | |
| 700 | 1 | |a Teirlinck, Anne C |e verfasserin |4 aut | |
| 700 | 1 | |a Lehtonen, Toni |e verfasserin |4 aut | |
| 700 | 1 | |a van Wijhe, Maarten |e verfasserin |4 aut | |
| 700 | 1 | |a Stona, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Bangert, Mathieu |e verfasserin |4 aut | |
| 700 | 1 | |a Reeves, Rachel M |e verfasserin |4 aut | |
| 700 | 1 | |a Bøås, Håkon |e verfasserin |4 aut | |
| 700 | 1 | |a van Boven, Michiel |e verfasserin |4 aut | |
| 700 | 1 | |a Heikkinen, Terho |e verfasserin |4 aut | |
| 700 | 1 | |a Klint Johannesen, Caroline |e verfasserin |4 aut | |
| 700 | 1 | |a Baraldi, Eugenio |e verfasserin |4 aut | |
| 700 | 1 | |a Donà, Daniele |e verfasserin |4 aut | |
| 700 | 1 | |a Tong, Sabine |e verfasserin |4 aut | |
| 700 | 1 | |a Campbell, Harry |e verfasserin |4 aut | |
| 700 | 0 | |a Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Reeves, Rachel M |e investigator |4 oth | |
| 700 | 1 | |a Li, You |e investigator |4 oth | |
| 700 | 1 | |a Wang, Xin |e investigator |4 oth | |
| 700 | 1 | |a Campbell, Harry |e investigator |4 oth | |
| 700 | 1 | |a Nair, Harish |e investigator |4 oth | |
| 700 | 1 | |a van Wijhe, Maarten |e investigator |4 oth | |
| 700 | 1 | |a Fischer, Thea Kølsen |e investigator |4 oth | |
| 700 | 1 | |a Simonsen, Lone |e investigator |4 oth | |
| 700 | 1 | |a Trebbien, Ramona |e investigator |4 oth | |
| 700 | 1 | |a Johannesen, Caroline Klint |e investigator |4 oth | |
| 700 | 1 | |a Tong, Sabine |e investigator |4 oth | |
| 700 | 1 | |a Bangert, Mathieu |e investigator |4 oth | |
| 700 | 1 | |a Demont, Clarisse |e investigator |4 oth | |
| 700 | 1 | |a Lehtonen, Toni |e investigator |4 oth | |
| 700 | 1 | |a Heikkinen, Terho |e investigator |4 oth | |
| 700 | 1 | |a Teirlinck, Anne C |e investigator |4 oth | |
| 700 | 1 | |a van Boven, Michiel |e investigator |4 oth | |
| 700 | 1 | |a van der Hoek, Wim |e investigator |4 oth | |
| 700 | 1 | |a van der Maas, Nicoline |e investigator |4 oth | |
| 700 | 1 | |a Meijer, Adam |e investigator |4 oth | |
| 700 | 1 | |a Fernandez, Liliana Vazquez |e investigator |4 oth | |
| 700 | 1 | |a Bøås, Håkon |e investigator |4 oth | |
| 700 | 1 | |a Bekkevold, Terese |e investigator |4 oth | |
| 700 | 1 | |a Flem, Elmira |e investigator |4 oth | |
| 700 | 1 | |a Stona, Luca |e investigator |4 oth | |
| 700 | 1 | |a Speltra, Irene |e investigator |4 oth | |
| 700 | 1 | |a Giaquinto, Carlo |e investigator |4 oth | |
| 700 | 1 | |a Baraldi, Eugenio |e investigator |4 oth | |
| 700 | 1 | |a Donà, Daniele |e investigator |4 oth | |
| 700 | 1 | |a Cheret, Arnaud |e investigator |4 oth | |
| 700 | 1 | |a Leach, Amanda |e investigator |4 oth | |
| 700 | 1 | |a Stoszek, Sonia |e investigator |4 oth | |
| 700 | 1 | |a Beutels, Philippe |e investigator |4 oth | |
| 700 | 1 | |a Bont, Louis |e investigator |4 oth | |
| 700 | 1 | |a Pollard, Andrew |e investigator |4 oth | |
| 700 | 1 | |a Openshaw, Peter |e investigator |4 oth | |
| 700 | 1 | |a Abram, Michael |e investigator |4 oth | |
| 700 | 1 | |a Swanson, Kena |e investigator |4 oth | |
| 700 | 1 | |a Rosen, Brian |e investigator |4 oth | |
| 700 | 1 | |a Molero, Eva |e investigator |4 oth | |
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