Clinical Characteristics and Predictors of Mortality in Obese African-Americans with COVID-19 : a Single-Center Retrospective Study
© 2021. W. Montague Cobb-NMA Health Institute..
BACKGROUND: This study aims to add to the body of evidence linking obesity as an established risk factor for COVID-19 infection and also look at predictors of mortality for COVID-19 in the African-Americans (AA) population.
METHODS: A retrospective cohort study of patients with confirmed COVID-19 infection was done in a community hospital in New York City. The cohort was divided into two groups, with the non-obese group having a BMI < 30 kg/m2 and the obese group with a BMI ≥ 30 kg/m2. Clinical predictors of mortality were assessed using multivariate regression analysis.
RESULTS: Among the 469 (AA) patients included in the study, 56.3% (n = 264) had a BMI < 30 kg/m2 and 43.7% (n = 205) had a BMI ≥ 30 kg/m2. Most common comorbidities were hypertension (n = 304, 64.8%), diabetes (n = 200, 42.6%), and dyslipidemia (n = 74, 15.8%). Cough, fever/chills, and shortness of breath had a higher percentage of occurring in the obese group (67.8 vs. 55.7%, p = 0.008; 58.0 vs. 46.2%, p = 0.011; 72.2 vs. 59.8%, p = 0.005, respectively). In-hospital mortality (41.5 vs. 25.4%, p < 0.001) and mechanical ventilation rates (34.6 vs. 22.7%, p = 0.004) were also greater for the obese group. Advanced age (p = 0.034), elevated sodium levels (p = 0.04), and elevated levels of AST (0.012) were associated with an increase in likelihood of in-hospital mortality in obese group.
CONCLUSIONS: Our results show that having a BMI that is ≥ 30 kg/m2 is a significant risk factor in COVID-19 morbidity and mortality. These results highlight the need for caution when managing obese individuals.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Journal of racial and ethnic health disparities - 10(2023), 1 vom: 13. Feb., Seite 160-167 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Garlapati, Pavani Reddy [VerfasserIn] |
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| Links: |
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| Themen: |
African-American |
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| Anmerkungen: |
Date Completed 05.01.2023 Date Revised 02.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s40615-021-01206-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM335579353 |
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| 100 | 1 | |a Garlapati, Pavani Reddy |e verfasserin |4 aut | |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. W. Montague Cobb-NMA Health Institute. | ||
| 520 | |a BACKGROUND: This study aims to add to the body of evidence linking obesity as an established risk factor for COVID-19 infection and also look at predictors of mortality for COVID-19 in the African-Americans (AA) population | ||
| 520 | |a METHODS: A retrospective cohort study of patients with confirmed COVID-19 infection was done in a community hospital in New York City. The cohort was divided into two groups, with the non-obese group having a BMI < 30 kg/m2 and the obese group with a BMI ≥ 30 kg/m2. Clinical predictors of mortality were assessed using multivariate regression analysis | ||
| 520 | |a RESULTS: Among the 469 (AA) patients included in the study, 56.3% (n = 264) had a BMI < 30 kg/m2 and 43.7% (n = 205) had a BMI ≥ 30 kg/m2. Most common comorbidities were hypertension (n = 304, 64.8%), diabetes (n = 200, 42.6%), and dyslipidemia (n = 74, 15.8%). Cough, fever/chills, and shortness of breath had a higher percentage of occurring in the obese group (67.8 vs. 55.7%, p = 0.008; 58.0 vs. 46.2%, p = 0.011; 72.2 vs. 59.8%, p = 0.005, respectively). In-hospital mortality (41.5 vs. 25.4%, p < 0.001) and mechanical ventilation rates (34.6 vs. 22.7%, p = 0.004) were also greater for the obese group. Advanced age (p = 0.034), elevated sodium levels (p = 0.04), and elevated levels of AST (0.012) were associated with an increase in likelihood of in-hospital mortality in obese group | ||
| 520 | |a CONCLUSIONS: Our results show that having a BMI that is ≥ 30 kg/m2 is a significant risk factor in COVID-19 morbidity and mortality. These results highlight the need for caution when managing obese individuals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a African-American | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a Predictors of mortality | |
| 700 | 1 | |a Kumar, Suneet |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Meet |e verfasserin |4 aut | |
| 700 | 1 | |a Sarker, Bidyut |e verfasserin |4 aut | |
| 700 | 1 | |a Tiongson, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Adapa, Sreedhar |e verfasserin |4 aut | |
| 700 | 1 | |a Salim, Sohail Abdul |e verfasserin |4 aut | |
| 700 | 1 | |a Adler, Mark K |e verfasserin |4 aut | |
| 700 | 1 | |a Gayam, Vijay Reddy |e verfasserin |4 aut | |
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