Hospital outcomes of community-acquired COVID-19 versus influenza : Insights from the Swiss hospital-based surveillance of influenza and COVID-19
BackgroundSince the onset of the COVID-19 pandemic, the disease has frequently been compared with seasonal influenza, but this comparison is based on little empirical data.AimThis study compares in-hospital outcomes for patients with community-acquired COVID-19 and patients with community-acquired influenza in Switzerland.MethodsThis retrospective multi-centre cohort study includes patients > 18 years admitted for COVID-19 or influenza A/B infection determined by RT-PCR. Primary and secondary outcomes were in-hospital mortality and intensive care unit (ICU) admission for patients with COVID-19 or influenza. We used Cox regression (cause-specific and Fine-Gray subdistribution hazard models) to account for time-dependency and competing events with inverse probability weighting to adjust for confounders.ResultsIn 2020, 2,843 patients with COVID-19 from 14 centres were included. Between 2018 and 2020, 1,381 patients with influenza from seven centres were included; 1,722 (61%) of the patients with COVID-19 and 666 (48%) of the patients with influenza were male (p < 0.001). The patients with COVID-19 were younger (median 67 years; interquartile range (IQR): 54-78) than the patients with influenza (median 74 years; IQR: 61-84) (p < 0.001). A larger percentage of patients with COVID-19 (12.8%) than patients with influenza (4.4%) died in hospital (p < 0.001). The final adjusted subdistribution hazard ratio for mortality was 3.01 (95% CI: 2.22-4.09; p < 0.001) for COVID-19 compared with influenza and 2.44 (95% CI: 2.00-3.00, p < 0.001) for ICU admission.ConclusionCommunity-acquired COVID-19 was associated with worse outcomes compared with community-acquired influenza, as the hazards of ICU admission and in-hospital death were about two-fold to three-fold higher.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
|---|---|
| Enthalten in: |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 27(2022), 1 vom: 07. Jan. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Fröhlich, Georg Marcus [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 11.01.2022 Date Revised 15.03.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.2807/1560-7917.ES.2022.27.1.2001848 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM335271154 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM335271154 | ||
| 003 | DE-627 | ||
| 005 | 20231225225443.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2807/1560-7917.ES.2022.27.1.2001848 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1117.xml |
| 035 | |a (DE-627)NLM335271154 | ||
| 035 | |a (NLM)34991775 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Fröhlich, Georg Marcus |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hospital outcomes of community-acquired COVID-19 versus influenza |b Insights from the Swiss hospital-based surveillance of influenza and COVID-19 |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.01.2022 | ||
| 500 | |a Date Revised 15.03.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BackgroundSince the onset of the COVID-19 pandemic, the disease has frequently been compared with seasonal influenza, but this comparison is based on little empirical data.AimThis study compares in-hospital outcomes for patients with community-acquired COVID-19 and patients with community-acquired influenza in Switzerland.MethodsThis retrospective multi-centre cohort study includes patients > 18 years admitted for COVID-19 or influenza A/B infection determined by RT-PCR. Primary and secondary outcomes were in-hospital mortality and intensive care unit (ICU) admission for patients with COVID-19 or influenza. We used Cox regression (cause-specific and Fine-Gray subdistribution hazard models) to account for time-dependency and competing events with inverse probability weighting to adjust for confounders.ResultsIn 2020, 2,843 patients with COVID-19 from 14 centres were included. Between 2018 and 2020, 1,381 patients with influenza from seven centres were included; 1,722 (61%) of the patients with COVID-19 and 666 (48%) of the patients with influenza were male (p < 0.001). The patients with COVID-19 were younger (median 67 years; interquartile range (IQR): 54-78) than the patients with influenza (median 74 years; IQR: 61-84) (p < 0.001). A larger percentage of patients with COVID-19 (12.8%) than patients with influenza (4.4%) died in hospital (p < 0.001). The final adjusted subdistribution hazard ratio for mortality was 3.01 (95% CI: 2.22-4.09; p < 0.001) for COVID-19 compared with influenza and 2.44 (95% CI: 2.00-3.00, p < 0.001) for ICU admission.ConclusionCommunity-acquired COVID-19 was associated with worse outcomes compared with community-acquired influenza, as the hazards of ICU admission and in-hospital death were about two-fold to three-fold higher | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a ICU | |
| 650 | 4 | |a Influenza | |
| 650 | 4 | |a Switzerland | |
| 650 | 4 | |a air-borne infections | |
| 650 | 4 | |a clinic | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a influenza | |
| 650 | 4 | |a influenza virus | |
| 650 | 4 | |a mortality | |
| 650 | 4 | |a severe acute respiratory syndrome – SARS | |
| 650 | 4 | |a surveillance | |
| 650 | 4 | |a viral infections | |
| 700 | 1 | |a De Kraker, Marlieke E A |e verfasserin |4 aut | |
| 700 | 1 | |a Abbas, Mohamed |e verfasserin |4 aut | |
| 700 | 1 | |a Keiser, Olivia |e verfasserin |4 aut | |
| 700 | 1 | |a Thiabaud, Amaury |e verfasserin |4 aut | |
| 700 | 1 | |a Roelens, Maroussia |e verfasserin |4 aut | |
| 700 | 1 | |a Cusini, Alexia |e verfasserin |4 aut | |
| 700 | 1 | |a Flury, Domenica |e verfasserin |4 aut | |
| 700 | 1 | |a Schreiber, Peter W |e verfasserin |4 aut | |
| 700 | 1 | |a Buettcher, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Corti, Natascia |e verfasserin |4 aut | |
| 700 | 1 | |a Vuichard-Gysin, Danielle |e verfasserin |4 aut | |
| 700 | 1 | |a Troillet, Nicolas |e verfasserin |4 aut | |
| 700 | 1 | |a Sauser, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Gaudenz, Roman |e verfasserin |4 aut | |
| 700 | 1 | |a Damonti, Lauro |e verfasserin |4 aut | |
| 700 | 1 | |a Balmelli, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Iten, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Widmer, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Harbarth, Stephan |e verfasserin |4 aut | |
| 700 | 1 | |a Sommerstein, Rami |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |d 1995 |g 27(2022), 1 vom: 07. Jan. |w (DE-627)NLM115683283 |x 1560-7917 |7 nnns |
| 773 | 1 | 8 | |g volume:27 |g year:2022 |g number:1 |g day:07 |g month:01 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2807/1560-7917.ES.2022.27.1.2001848 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 27 |j 2022 |e 1 |b 07 |c 01 | ||