Clinical heterogeneity in patients with myoclonus associated to COVID-19
© 2021. Fondazione Società Italiana di Neurologia..
OBJECTIVE: This study aims to report the clinical heterogeneity of myoclonus in 6 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
METHODS: Patient data were obtained from medical records from the University Hospital Dr. Josep Trueta, Girona, Spain.
RESULTS: Six patients (5 men and 1 woman, aged 60-76 years) presented with different myoclonus phenotypes. All of them had a medical history of hypertension and overweight. The latency of myoclonus appearance ranged from 1 to 129 days. The phenotype most observed was generalized myoclonus. Special phenotypes such as painful legs and moving toes syndrome with jerking feet, Lazarus sign-like, action myoclonus/ataxia syndrome, and segmental myoclonus secondary to myelitis have been described too. Levetiracetam and clonazepam were medications most used successfully. Two patients died for complications not related to myoclonus.
CONCLUSIONS: Our 6 cases highlight the heterogeneity of the clinical spectrum of myoclonus associated to COVID-19 (MYaCO). MYaCO pathogenesis is suspected to be due to an immune-mediated para- or post-infectious phenomenon; nevertheless, further research is needed to elucidate this hypothesis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 43(2022), 3 vom: 05. März, Seite 1587-1592 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Álvarez Bravo, Gary [VerfasserIn] |
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| Links: |
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| Themen: |
Ataxia |
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| Anmerkungen: |
Date Completed 23.02.2022 Date Revised 16.07.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10072-021-05802-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM335240836 |
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| 245 | 1 | 0 | |a Clinical heterogeneity in patients with myoclonus associated to COVID-19 |
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| 500 | |a Date Completed 23.02.2022 | ||
| 500 | |a Date Revised 16.07.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. Fondazione Società Italiana di Neurologia. | ||
| 520 | |a OBJECTIVE: This study aims to report the clinical heterogeneity of myoclonus in 6 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) | ||
| 520 | |a METHODS: Patient data were obtained from medical records from the University Hospital Dr. Josep Trueta, Girona, Spain | ||
| 520 | |a RESULTS: Six patients (5 men and 1 woman, aged 60-76 years) presented with different myoclonus phenotypes. All of them had a medical history of hypertension and overweight. The latency of myoclonus appearance ranged from 1 to 129 days. The phenotype most observed was generalized myoclonus. Special phenotypes such as painful legs and moving toes syndrome with jerking feet, Lazarus sign-like, action myoclonus/ataxia syndrome, and segmental myoclonus secondary to myelitis have been described too. Levetiracetam and clonazepam were medications most used successfully. Two patients died for complications not related to myoclonus | ||
| 520 | |a CONCLUSIONS: Our 6 cases highlight the heterogeneity of the clinical spectrum of myoclonus associated to COVID-19 (MYaCO). MYaCO pathogenesis is suspected to be due to an immune-mediated para- or post-infectious phenomenon; nevertheless, further research is needed to elucidate this hypothesis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Ataxia | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Encephalopathy | |
| 650 | 4 | |a Myoclonus | |
| 650 | 4 | |a SARS-CoV2 | |
| 700 | 1 | |a Sánchez Cirera, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Angerri Nadal, Mònica |e verfasserin |4 aut | |
| 700 | 1 | |a Ramió I Torrentà, Lluís |e verfasserin |4 aut | |
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