Human KIR + CD8 + T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19
Previous reports show that Ly49 + CD8 + T cells can suppress autoimmunity in mouse models of autoimmune diseases. Here we find a markedly increased frequency of CD8 + T cells expressing inhibitory Killer cell Immunoglobulin like Receptors (KIR), the human equivalent of the Ly49 family, in the blood and inflamed tissues of various autoimmune diseases. Moreover, KIR + CD8 + T cells can efficiently eliminate pathogenic gliadin-specific CD4 + T cells from Celiac disease (CeD) patients' leukocytes in vitro . Furthermore, we observe elevated levels of KIR + CD8 + T cells, but not CD4 + regulatory T cells, in COVID-19 and influenza-infected patients, and this correlates with disease severity and vasculitis in COVID-19. Expanded KIR + CD8 + T cells from these different diseases display shared phenotypes and similar T cell receptor sequences. These results characterize a regulatory CD8 + T cell subset in humans, broadly active in both autoimmune and infectious diseases, which we hypothesize functions to control self-reactive or otherwise pathogenic T cells.
ONE-SENTENCE SUMMARY: Here we identified KIR + CD8 + T cells as a regulatory CD8 + T cell subset in humans that suppresses self-reactive or otherwise pathogenic CD4 + T cells.
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E-Artikel |
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2021 |
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| Erschienen: |
2021 |
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Zur Gesamtaufnahme - year:2021 |
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| Enthalten in: |
bioRxiv : the preprint server for biology - (2021) vom: 25. Dez. |
| Sprache: |
Englisch |
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Date Revised 29.04.2022 published: Electronic UpdateIn: Science. 2022 Mar 8;:eabi9591. - PMID 35258337 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1101/2021.12.23.473930 |
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NLM335165087 |
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| 100 | 1 | |a Li, Jing |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Human KIR + CD8 + T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19 |
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| 500 | |a Date Revised 29.04.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a UpdateIn: Science. 2022 Mar 8;:eabi9591. - PMID 35258337 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Previous reports show that Ly49 + CD8 + T cells can suppress autoimmunity in mouse models of autoimmune diseases. Here we find a markedly increased frequency of CD8 + T cells expressing inhibitory Killer cell Immunoglobulin like Receptors (KIR), the human equivalent of the Ly49 family, in the blood and inflamed tissues of various autoimmune diseases. Moreover, KIR + CD8 + T cells can efficiently eliminate pathogenic gliadin-specific CD4 + T cells from Celiac disease (CeD) patients' leukocytes in vitro . Furthermore, we observe elevated levels of KIR + CD8 + T cells, but not CD4 + regulatory T cells, in COVID-19 and influenza-infected patients, and this correlates with disease severity and vasculitis in COVID-19. Expanded KIR + CD8 + T cells from these different diseases display shared phenotypes and similar T cell receptor sequences. These results characterize a regulatory CD8 + T cell subset in humans, broadly active in both autoimmune and infectious diseases, which we hypothesize functions to control self-reactive or otherwise pathogenic T cells | ||
| 520 | |a ONE-SENTENCE SUMMARY: Here we identified KIR + CD8 + T cells as a regulatory CD8 + T cell subset in humans that suppresses self-reactive or otherwise pathogenic CD4 + T cells | ||
| 650 | 4 | |a Preprint | |
| 700 | 1 | |a Zaslavsky, Maxim |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Yapeng |e verfasserin |4 aut | |
| 700 | 1 | |a Sikora, Michael J |e verfasserin |4 aut | |
| 700 | 1 | |a van Unen, Vincent |e verfasserin |4 aut | |
| 700 | 1 | |a Christophersen, Asbjørn |e verfasserin |4 aut | |
| 700 | 1 | |a Chiou, Shin-Heng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jiefu |e verfasserin |4 aut | |
| 700 | 1 | |a Ji, Xuhuai |e verfasserin |4 aut | |
| 700 | 1 | |a Wilhelmy, Julie |e verfasserin |4 aut | |
| 700 | 1 | |a McSween, Alana M |e verfasserin |4 aut | |
| 700 | 1 | |a Palanski, Brad A |e verfasserin |4 aut | |
| 700 | 1 | |a Aditya Mallajosyula, Venkata Vamsee |e verfasserin |4 aut | |
| 700 | 1 | |a Dhondalay, Gopal Krishna R |e verfasserin |4 aut | |
| 700 | 1 | |a Bhamidipati, Kartik |e verfasserin |4 aut | |
| 700 | 1 | |a Pai, Joy |e verfasserin |4 aut | |
| 700 | 1 | |a Kipp, Lucas B |e verfasserin |4 aut | |
| 700 | 1 | |a Dunn, Jeffrey E |e verfasserin |4 aut | |
| 700 | 1 | |a Hauser, Stephen L |e verfasserin |4 aut | |
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| 700 | 1 | |a Satpathy, Ansuman T |e verfasserin |4 aut | |
| 700 | 1 | |a Robinson, William H |e verfasserin |4 aut | |
| 700 | 1 | |a Steinmetz, Lars M |e verfasserin |4 aut | |
| 700 | 1 | |a Khosla, Chaitan |e verfasserin |4 aut | |
| 700 | 1 | |a Utz, Paul J |e verfasserin |4 aut | |
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