Progression to a severe form of COVID-19 among patients with chronic respiratory diseases
Copyright © 2021 SPLF and Elsevier Masson SAS. All rights reserved..
RATIONALE: Viral respiratory infections, including SARS-CoV-2 infection, can trigger respiratory symptoms among patients suffering from chronic respiratory diseases, leading to exacerbations and hospitalizations. Despite the tropism of SARS-CoV-2 into the respiratory tract, chronic respiratory diseases do not seem to be risk factors for severe forms of COVID-19.
OBJECTIVES: To assess whether hospitalized patients for COVID-19 with chronic respiratory diseases were at lower risk of developing a severe form than other patients.
METHODS: This French study included patients admitted to hospital in COVID-19 ward, suffering from a SARS-CoV-2 infection, diagnosed on RT-PCR or chest computed tomography associated with clinical symptoms, from March 15 to June 30, 2020. Ambulatory patients who were tested in the emergency department and patients with severe hypoxaemia requiring intensive care were not included. All data were collected from electronic medical records up to discharge of the patient.
MAIN RESULTS: 617 patients were included: 125 with a chronic respiratory disease, mainly chronic obstructive pulmonary disease (45%) and asthma (30%). The percentage of patients scoring 6 or higher on the WHO Clinical Progression Scale during hospital stay was lower in patients with chronic respiratory disease compared to those without chronic respiratory disease (21.6% versus 31.3%, respectively, p = 0.03). Among patients with chronic respiratory disease, temperature above 38 °C on admission (OR 16.88 (95% CI 4.01-71.00)), lymphopenia (OR 5.08 (1.25-20.72)), CPAP therapy (OR 4.46 (1.04-19.17)) and age (OR 1.09 (1.02-1.16)) were associated with an increased risk to reach a score of 6 or above.
CONCLUSIONS: Hospital admissions in COVID-19 ward of patients suffering from chronic respiratory diseases are at lower risk of developing a severe form of COVID- 19, especially in patients with chronic obstructive pulmonary disease or asthma. Prospective studies would confirm our results and allow to better organize the follow-up of these patients in a pandemic period.
| Errataetall: |
CommentIn: Respir Med Res. 2022 May;81:100895. - PMID 35259577 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:81 |
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| Enthalten in: |
Respiratory medicine and research - 81(2022) vom: 15. Mai, Seite 100880 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Basin, Sarah [VerfasserIn] |
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| Links: |
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| Themen: |
Asthma |
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| Anmerkungen: |
Date Completed 21.06.2022 Date Revised 26.11.2022 published: Print-Electronic CommentIn: Respir Med Res. 2022 May;81:100895. - PMID 35259577 Citation Status MEDLINE |
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| doi: |
10.1016/j.resmer.2021.100880 |
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| PPN (Katalog-ID): |
NLM335096891 |
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| 245 | 1 | 0 | |a Progression to a severe form of COVID-19 among patients with chronic respiratory diseases |
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| 500 | |a Date Completed 21.06.2022 | ||
| 500 | |a Date Revised 26.11.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Respir Med Res. 2022 May;81:100895. - PMID 35259577 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 SPLF and Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a RATIONALE: Viral respiratory infections, including SARS-CoV-2 infection, can trigger respiratory symptoms among patients suffering from chronic respiratory diseases, leading to exacerbations and hospitalizations. Despite the tropism of SARS-CoV-2 into the respiratory tract, chronic respiratory diseases do not seem to be risk factors for severe forms of COVID-19 | ||
| 520 | |a OBJECTIVES: To assess whether hospitalized patients for COVID-19 with chronic respiratory diseases were at lower risk of developing a severe form than other patients | ||
| 520 | |a METHODS: This French study included patients admitted to hospital in COVID-19 ward, suffering from a SARS-CoV-2 infection, diagnosed on RT-PCR or chest computed tomography associated with clinical symptoms, from March 15 to June 30, 2020. Ambulatory patients who were tested in the emergency department and patients with severe hypoxaemia requiring intensive care were not included. All data were collected from electronic medical records up to discharge of the patient | ||
| 520 | |a MAIN RESULTS: 617 patients were included: 125 with a chronic respiratory disease, mainly chronic obstructive pulmonary disease (45%) and asthma (30%). The percentage of patients scoring 6 or higher on the WHO Clinical Progression Scale during hospital stay was lower in patients with chronic respiratory disease compared to those without chronic respiratory disease (21.6% versus 31.3%, respectively, p = 0.03). Among patients with chronic respiratory disease, temperature above 38 °C on admission (OR 16.88 (95% CI 4.01-71.00)), lymphopenia (OR 5.08 (1.25-20.72)), CPAP therapy (OR 4.46 (1.04-19.17)) and age (OR 1.09 (1.02-1.16)) were associated with an increased risk to reach a score of 6 or above | ||
| 520 | |a CONCLUSIONS: Hospital admissions in COVID-19 ward of patients suffering from chronic respiratory diseases are at lower risk of developing a severe form of COVID- 19, especially in patients with chronic obstructive pulmonary disease or asthma. Prospective studies would confirm our results and allow to better organize the follow-up of these patients in a pandemic period | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Asthma | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Chronic obstructive lung disease | |
| 650 | 4 | |a Chronic respiratory failure | |
| 650 | 4 | |a Respiratory intensive care | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Viral infections of the respiratory tract | |
| 700 | 1 | |a Valentin, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Maurac, Arnaud |e verfasserin |4 aut | |
| 700 | 1 | |a Poussel, Mathias |e verfasserin |4 aut | |
| 700 | 1 | |a Pequignot, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Brindel, Aurélien |e verfasserin |4 aut | |
| 700 | 1 | |a Poupet, Guillaume |e verfasserin |4 aut | |
| 700 | 1 | |a Robert, Céline |e verfasserin |4 aut | |
| 700 | 1 | |a Baumann, Cédric |e verfasserin |4 aut | |
| 700 | 1 | |a Luc, Amandine |e verfasserin |4 aut | |
| 700 | 1 | |a Soler, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Chabot, François |e verfasserin |4 aut | |
| 700 | 1 | |a Chaouat, Ari |e verfasserin |4 aut | |
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