Gut microbiomes from Gambian infants reveal the development of a non-industrialized Prevotella-based trophic network
© 2022. The Author(s)..
Distinct bacterial trophic networks exist in the gut microbiota of individuals in industrialized and non-industrialized countries. In particular, non-industrialized gut microbiomes tend to be enriched with Prevotella species. To study the development of these Prevotella-rich compositions, we investigated the gut microbiota of children aged between 7 and 37 months living in rural Gambia (616 children, 1,389 stool samples, stratified by 3-month age groups). These infants, who typically eat a high-fibre, low-protein diet, were part of a double-blind, randomized iron intervention trial (NCT02941081) and here we report the secondary outcome. We found that child age was the largest discriminating factor between samples and that anthropometric indices (collection time points, season, geographic collection site, and iron supplementation) did not significantly influence the gut microbiome. Prevotella copri, Faecalibacterium prausnitzii and Prevotella stercorea were, on average, the most abundant species in these 1,389 samples (35%, 11% and 7%, respectively). Distinct bacterial trophic network clusters were identified, centred around either P. stercorea or F. prausnitzii and were found to develop steadily with age, whereas P. copri, independently of other species, rapidly became dominant after weaning. This dataset, set within a critical gut microbial developmental time frame, provides insights into the development of Prevotella-rich gut microbiomes, which are typically understudied and are underrepresented in western populations.
| Errataetall: |
CommentIn: Nat Microbiol. 2022 Jan;7(1):18-19. - PMID 34972823 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Nature microbiology - 7(2022), 1 vom: 26. Jan., Seite 132-144 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Goffau, Marcus C [VerfasserIn] |
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Date Completed 22.02.2022 Date Revised 29.02.2024 published: Print-Electronic ClinicalTrials.gov: NCT02941081 CommentIn: Nat Microbiol. 2022 Jan;7(1):18-19. - PMID 34972823 Citation Status MEDLINE |
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| doi: |
10.1038/s41564-021-01023-6 |
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| 500 | |a CommentIn: Nat Microbiol. 2022 Jan;7(1):18-19. - PMID 34972823 | ||
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| 520 | |a © 2022. The Author(s). | ||
| 520 | |a Distinct bacterial trophic networks exist in the gut microbiota of individuals in industrialized and non-industrialized countries. In particular, non-industrialized gut microbiomes tend to be enriched with Prevotella species. To study the development of these Prevotella-rich compositions, we investigated the gut microbiota of children aged between 7 and 37 months living in rural Gambia (616 children, 1,389 stool samples, stratified by 3-month age groups). These infants, who typically eat a high-fibre, low-protein diet, were part of a double-blind, randomized iron intervention trial (NCT02941081) and here we report the secondary outcome. We found that child age was the largest discriminating factor between samples and that anthropometric indices (collection time points, season, geographic collection site, and iron supplementation) did not significantly influence the gut microbiome. Prevotella copri, Faecalibacterium prausnitzii and Prevotella stercorea were, on average, the most abundant species in these 1,389 samples (35%, 11% and 7%, respectively). Distinct bacterial trophic network clusters were identified, centred around either P. stercorea or F. prausnitzii and were found to develop steadily with age, whereas P. copri, independently of other species, rapidly became dominant after weaning. This dataset, set within a critical gut microbial developmental time frame, provides insights into the development of Prevotella-rich gut microbiomes, which are typically understudied and are underrepresented in western populations | ||
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| 700 | 1 | |a Jallow, Amadou T |e verfasserin |4 aut | |
| 700 | 1 | |a Sanyang, Chilel |e verfasserin |4 aut | |
| 700 | 1 | |a Prentice, Andrew M |e verfasserin |4 aut | |
| 700 | 1 | |a Meagher, Niamh |e verfasserin |4 aut | |
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| 700 | 1 | |a Parkhill, Julian |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira, Dora I A |e verfasserin |4 aut | |
| 700 | 1 | |a Wagner, Josef |e verfasserin |4 aut | |
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