Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients : A Retrospective Cohort Study
Copyright © 2021 van Son, Oussaada, Şekercan, Beudel, Dongelmans, van Assen, Eland, Moeniralam, Dormans, van Kalkeren, Douma, Rusch, Simsek, Liu, Kootte, Wyers, IJzerman, van den Bergh, Stehouwer, Nieuwdorp, ter Horst and Serlie..
Objective: To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.
Design: Retrospective, observational cohort study.
Methods: We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.
Results: Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients.
Conclusion: In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Frontiers in endocrinology - 12(2021) vom: 01., Seite 747732 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
van Son, Jamie [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 13.01.2022 Date Revised 13.01.2022 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fendo.2021.747732 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a van Son, Jamie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients |b A Retrospective Cohort Study |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 13.01.2022 | ||
| 500 | |a Date Revised 13.01.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 van Son, Oussaada, Şekercan, Beudel, Dongelmans, van Assen, Eland, Moeniralam, Dormans, van Kalkeren, Douma, Rusch, Simsek, Liu, Kootte, Wyers, IJzerman, van den Bergh, Stehouwer, Nieuwdorp, ter Horst and Serlie. | ||
| 520 | |a Objective: To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19 | ||
| 520 | |a Design: Retrospective, observational cohort study | ||
| 520 | |a Methods: We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes | ||
| 520 | |a Results: Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients | ||
| 520 | |a Conclusion: In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a complications | |
| 650 | 4 | |a mortality | |
| 650 | 4 | |a obesity | |
| 650 | 4 | |a overweight | |
| 700 | 1 | |a Oussaada, Sabrina M |e verfasserin |4 aut | |
| 700 | 1 | |a Şekercan, Aydin |e verfasserin |4 aut | |
| 700 | 1 | |a Beudel, Martijn |e verfasserin |4 aut | |
| 700 | 1 | |a Dongelmans, Dave A |e verfasserin |4 aut | |
| 700 | 1 | |a van Assen, Sander |e verfasserin |4 aut | |
| 700 | 1 | |a Eland, Ingo A |e verfasserin |4 aut | |
| 700 | 1 | |a Moeniralam, Hazra S |e verfasserin |4 aut | |
| 700 | 1 | |a Dormans, Tom P J |e verfasserin |4 aut | |
| 700 | 1 | |a van Kalkeren, Colin A J |e verfasserin |4 aut | |
| 700 | 1 | |a Douma, Renée A |e verfasserin |4 aut | |
| 700 | 1 | |a Rusch, Daisy |e verfasserin |4 aut | |
| 700 | 1 | |a Simsek, Suat |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Limmie |e verfasserin |4 aut | |
| 700 | 1 | |a Kootte, Ruud S |e verfasserin |4 aut | |
| 700 | 1 | |a Wyers, Caroline E |e verfasserin |4 aut | |
| 700 | 1 | |a IJzerman, Richard G |e verfasserin |4 aut | |
| 700 | 1 | |a van den Bergh, Joop P |e verfasserin |4 aut | |
| 700 | 1 | |a Stehouwer, Coen D A |e verfasserin |4 aut | |
| 700 | 1 | |a Nieuwdorp, Max |e verfasserin |4 aut | |
| 700 | 1 | |a Ter Horst, Kasper W |e verfasserin |4 aut | |
| 700 | 1 | |a Serlie, Mireille J |e verfasserin |4 aut | |
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