Fructooligosaccharides on inflammation, immunomodulation, oxidative stress, and gut immune response : a systematic review
© The Author(s) 2021. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
CONTEXT: Evidence shows that fructooligosaccharides (FOSs) can modulate inflammatory, oxidative, and immune activity in the gut, possibly leading to a systemic response, improving human health.
OBJECTIVE: To assess the present knowledge of the effects of FOSs on inflammation, immunomodulation, oxidative stress, and gut immune response.
DATA SOURCES: Studies published between December 2000 and January 2020 were systematically searched in four databases: MEDLINE, LILACS, Web of Science, and Scopus. After the screening of 1316 articles, 8 human studies and 20 animal models were included.
DATA EXTRACTION: Data were extracted separately by 2 reviewers. For each study, the design, population, exposures, main results, and conclusion were extracted. The research questions and the risk-of-bias information were also extracted. Additionally, the risk-of-bias were analyzed to guarantee the reliability of this review.
DATA ANALYSIS: A qualitative analysis revealed that FOSs can increase bifidobacteria counts and short-chain fatty acids in the gut, stimulate IgA secretion in the colon, and decrease proinflammatory cytokines, thus influencing metabolic diseases.
CONCLUSION: Studies suggest that FOS supplementation is positively associated with an anti-inflammatory and antioxidant effect, thus enhancing the gut immune system, which may be beneficial for the host's health.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration nos 42020209865 and 42020220369.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:80 |
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| Enthalten in: |
Nutrition reviews - 80(2022), 4 vom: 10. März, Seite 709-722 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Costa, Graciana T [VerfasserIn] |
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| Links: |
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| Themen: |
Fructooligosaccharide |
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| Anmerkungen: |
Date Completed 30.03.2022 Date Revised 29.04.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/nutrit/nuab115 |
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| PPN (Katalog-ID): |
NLM335027504 |
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| 500 | |a Date Revised 29.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2021. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a CONTEXT: Evidence shows that fructooligosaccharides (FOSs) can modulate inflammatory, oxidative, and immune activity in the gut, possibly leading to a systemic response, improving human health | ||
| 520 | |a OBJECTIVE: To assess the present knowledge of the effects of FOSs on inflammation, immunomodulation, oxidative stress, and gut immune response | ||
| 520 | |a DATA SOURCES: Studies published between December 2000 and January 2020 were systematically searched in four databases: MEDLINE, LILACS, Web of Science, and Scopus. After the screening of 1316 articles, 8 human studies and 20 animal models were included | ||
| 520 | |a DATA EXTRACTION: Data were extracted separately by 2 reviewers. For each study, the design, population, exposures, main results, and conclusion were extracted. The research questions and the risk-of-bias information were also extracted. Additionally, the risk-of-bias were analyzed to guarantee the reliability of this review | ||
| 520 | |a DATA ANALYSIS: A qualitative analysis revealed that FOSs can increase bifidobacteria counts and short-chain fatty acids in the gut, stimulate IgA secretion in the colon, and decrease proinflammatory cytokines, thus influencing metabolic diseases | ||
| 520 | |a CONCLUSION: Studies suggest that FOS supplementation is positively associated with an anti-inflammatory and antioxidant effect, thus enhancing the gut immune system, which may be beneficial for the host's health | ||
| 520 | |a SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration nos 42020209865 and 42020220369 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a fructooligosaccharides | |
| 650 | 4 | |a gut immune response | |
| 650 | 4 | |a immunomodulation | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a oxidative stress | |
| 650 | 7 | |a Oligosaccharides |2 NLM | |
| 650 | 7 | |a fructooligosaccharide |2 NLM | |
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| 700 | 1 | |a Aragão, Gislei F |e verfasserin |4 aut | |
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