Adult lifetime body mass index trajectories and endometrial cancer risk
© 2021 John Wiley & Sons Ltd..
OBJECTIVE: To identify body mass index (BMI) trajectories in adult life and to examine their association with endometrial cancer (EC) risk, also exploring whether relations differ by hormonal replacement therapy use.
DESIGN: Pooled analysis of two case-control studies.
SETTING: Italy and Switzerland.
POPULATION: A total of 458 EC cases and 782 controls.
METHODS: We performed a latent class growth model to identify homogeneous BMI trajectories over six decades of age, with a polynomial function of age. Odds ratios (ORs) and the corresponding 95% CI for EC risk were derived through a multiple logistic regression model, correcting for classification error.
MAIN OUTCOME MEASURES: The relation of BMI trajectories with endometrial cancer.
RESULTS: We identified five BMI trajectories. Compared with women in the 'Normal weight-stable' trajectory, a reduction by about 50% in the risk of EC emerged for those in the 'Underweight increasing to normal weight' (95% CI 0.28-0.99). The 'Normal weight increasing to overweight' and the 'Overweight-stable' trajectories were associated with, respectively, an excess of 3% (95% CI 0.66-1.60) and of 71% (95% CI 1.12-2.59) in cancer risk. The OR associated to the trajectory 'Overweight increasing to obese' was 2.03 (95% CI 1.31-3.13). Stronger effects emerged among hormonal replacement therapy never users (OR 2.19 for the 'Overweight-stable' trajectory and OR 2.49 for the 'Overweight increasing to obese' trajectory).
CONCLUSIONS: Our study suggests that longer exposure to overweight and obesity across a lifetime is associated with an increased risk of endometrial cancer. Weight during adulthood also appears to play an important role.
TWEETABLE ABSTRACT: Longer exposure to overweight and obesity across a lifetime is associated with an increased risk of endometrial cancer.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:129 |
|---|---|
| Enthalten in: |
BJOG : an international journal of obstetrics and gynaecology - 129(2022), 9 vom: 01. Aug., Seite 1521-1529 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Dalmartello, Michela [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Body mass index |
|---|
| Anmerkungen: |
Date Completed 12.07.2022 Date Revised 13.07.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/1471-0528.17087 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM334985293 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM334985293 | ||
| 003 | DE-627 | ||
| 005 | 20231225224845.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/1471-0528.17087 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1116.xml |
| 035 | |a (DE-627)NLM334985293 | ||
| 035 | |a (NLM)34962692 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Dalmartello, Michela |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Adult lifetime body mass index trajectories and endometrial cancer risk |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 12.07.2022 | ||
| 500 | |a Date Revised 13.07.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 John Wiley & Sons Ltd. | ||
| 520 | |a OBJECTIVE: To identify body mass index (BMI) trajectories in adult life and to examine their association with endometrial cancer (EC) risk, also exploring whether relations differ by hormonal replacement therapy use | ||
| 520 | |a DESIGN: Pooled analysis of two case-control studies | ||
| 520 | |a SETTING: Italy and Switzerland | ||
| 520 | |a POPULATION: A total of 458 EC cases and 782 controls | ||
| 520 | |a METHODS: We performed a latent class growth model to identify homogeneous BMI trajectories over six decades of age, with a polynomial function of age. Odds ratios (ORs) and the corresponding 95% CI for EC risk were derived through a multiple logistic regression model, correcting for classification error | ||
| 520 | |a MAIN OUTCOME MEASURES: The relation of BMI trajectories with endometrial cancer | ||
| 520 | |a RESULTS: We identified five BMI trajectories. Compared with women in the 'Normal weight-stable' trajectory, a reduction by about 50% in the risk of EC emerged for those in the 'Underweight increasing to normal weight' (95% CI 0.28-0.99). The 'Normal weight increasing to overweight' and the 'Overweight-stable' trajectories were associated with, respectively, an excess of 3% (95% CI 0.66-1.60) and of 71% (95% CI 1.12-2.59) in cancer risk. The OR associated to the trajectory 'Overweight increasing to obese' was 2.03 (95% CI 1.31-3.13). Stronger effects emerged among hormonal replacement therapy never users (OR 2.19 for the 'Overweight-stable' trajectory and OR 2.49 for the 'Overweight increasing to obese' trajectory) | ||
| 520 | |a CONCLUSIONS: Our study suggests that longer exposure to overweight and obesity across a lifetime is associated with an increased risk of endometrial cancer. Weight during adulthood also appears to play an important role | ||
| 520 | |a TWEETABLE ABSTRACT: Longer exposure to overweight and obesity across a lifetime is associated with an increased risk of endometrial cancer | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a body mass index | |
| 650 | 4 | |a body mass index trajectories | |
| 650 | 4 | |a endometrial cancer | |
| 650 | 4 | |a latent class growth models | |
| 650 | 4 | |a prevention | |
| 700 | 1 | |a Vermunt, Jeroen |e verfasserin |4 aut | |
| 700 | 1 | |a Negri, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Levi, Fabio |e verfasserin |4 aut | |
| 700 | 1 | |a La Vecchia, Carlo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t BJOG : an international journal of obstetrics and gynaecology |d 2000 |g 129(2022), 9 vom: 01. Aug., Seite 1521-1529 |w (DE-627)NLM10574820X |x 1471-0528 |7 nnns |
| 773 | 1 | 8 | |g volume:129 |g year:2022 |g number:9 |g day:01 |g month:08 |g pages:1521-1529 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/1471-0528.17087 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 129 |j 2022 |e 9 |b 01 |c 08 |h 1521-1529 | ||