miR-223 : An Immune Regulator in Infectious Disorders
Copyright © 2021 Yuan, Wu, Wang, Che, Zheng, Chen, Zhong and Shi..
MicroRNAs (miRNAs) are diminutive noncoding RNAs that can influence disease development and progression by post-transcriptionally regulating gene expression. The anti-inflammatory miRNA, miR-223, was first identified as a regulator of myelopoietic differentiation in 2003. This miR-223 exhibits multiple regulatory functions in the immune response, and abnormal expression of miR-223 is shown to be associated with multiple infectious diseases, including viral hepatitis, human immunodeficiency virus type 1 (HIV-1), and tuberculosis (TB) by influencing neutrophil infiltration, macrophage function, dendritic cell (DC) maturation and inflammasome activation. This review summarizes the current understanding of miR-223 physiopathology and highlights the molecular mechanism by which miR-223 regulates immune responses to infectious diseases and how it may be targeted for diagnosis and treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Frontiers in immunology - 12(2021) vom: 20., Seite 781815 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yuan, Shun [VerfasserIn] |
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| Links: |
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| Themen: |
Activation |
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| Anmerkungen: |
Date Completed 09.02.2022 Date Revised 09.02.2022 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fimmu.2021.781815 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM33492099X |
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| 520 | |a Copyright © 2021 Yuan, Wu, Wang, Che, Zheng, Chen, Zhong and Shi. | ||
| 520 | |a MicroRNAs (miRNAs) are diminutive noncoding RNAs that can influence disease development and progression by post-transcriptionally regulating gene expression. The anti-inflammatory miRNA, miR-223, was first identified as a regulator of myelopoietic differentiation in 2003. This miR-223 exhibits multiple regulatory functions in the immune response, and abnormal expression of miR-223 is shown to be associated with multiple infectious diseases, including viral hepatitis, human immunodeficiency virus type 1 (HIV-1), and tuberculosis (TB) by influencing neutrophil infiltration, macrophage function, dendritic cell (DC) maturation and inflammasome activation. This review summarizes the current understanding of miR-223 physiopathology and highlights the molecular mechanism by which miR-223 regulates immune responses to infectious diseases and how it may be targeted for diagnosis and treatment | ||
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| 700 | 1 | |a Wang, Zhiwei |e verfasserin |4 aut | |
| 700 | 1 | |a Che, Yanjia |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Sihao |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yuanyang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Xiaohan |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Feng |e verfasserin |4 aut | |
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