Adenosquamous cancer of the pancreas : A multicenter retrospective study
Copyright © 2021. Publicado por Elsevier España, S.L.U..
INTRODUCTION: Adenosquamous cancer of the pancreas (ASCP) is an aggressive, infrequent subtype of pancreatic cancer that combines a glandular and squamous component and is associated with poor survival.
METHODS: Multicenter retrospective observational study carried out at three Spanish hospitals. The study period was: January 2010-August 2020. A descriptive analysis of the data was performed, as well as an analysis of global and disease-free survival using the Kaplan-Meier statistic.
RESULTS: Of a total of 668 pancreatic cancers treated surgically, twelve were ASCP (1.8%). Patient mean age was 69.2±7.4 years. Male/female ratio was 1:1. The main symptom was jaundice (seven patients). Correct preoperative diagnosis was obtained in only two patients. Nine pancreatoduodenectomies and three distal pancreatosplenectomies were performed. 25% had major complications. Mean tumor size was 48.6±19.4mm. Nine patients received adjuvant chemotherapy. Median survival time was 5.9 months, and median disease-free survival was 4.6 months. 90% of patients presented recurrence. Ten of the twelve patients in the study (83.3%) died, with disease progression being the cause in eight. Of the two surviving patients, one is disease-free and the other has liver metastases.
CONCLUSION: ASCP is a very rare pancreatic tumor with aggressive behavior. It is rarely diagnosed preoperatively. The best treatment, if feasible, is surgery followed by the standard chemotherapy regimens for pancreatic adenocarcinoma.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Gastroenterologia y hepatologia - 45(2022), 7 vom: 01. Aug., Seite 543-551 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ramia-Angel, José Manuel [VerfasserIn] |
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| Links: |
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| Themen: |
Adenoescamoso |
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| Anmerkungen: |
Date Completed 19.07.2022 Date Revised 26.07.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.gastrohep.2021.12.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM334880327 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021. Publicado por Elsevier España, S.L.U. | ||
| 520 | |a INTRODUCTION: Adenosquamous cancer of the pancreas (ASCP) is an aggressive, infrequent subtype of pancreatic cancer that combines a glandular and squamous component and is associated with poor survival | ||
| 520 | |a METHODS: Multicenter retrospective observational study carried out at three Spanish hospitals. The study period was: January 2010-August 2020. A descriptive analysis of the data was performed, as well as an analysis of global and disease-free survival using the Kaplan-Meier statistic | ||
| 520 | |a RESULTS: Of a total of 668 pancreatic cancers treated surgically, twelve were ASCP (1.8%). Patient mean age was 69.2±7.4 years. Male/female ratio was 1:1. The main symptom was jaundice (seven patients). Correct preoperative diagnosis was obtained in only two patients. Nine pancreatoduodenectomies and three distal pancreatosplenectomies were performed. 25% had major complications. Mean tumor size was 48.6±19.4mm. Nine patients received adjuvant chemotherapy. Median survival time was 5.9 months, and median disease-free survival was 4.6 months. 90% of patients presented recurrence. Ten of the twelve patients in the study (83.3%) died, with disease progression being the cause in eight. Of the two surviving patients, one is disease-free and the other has liver metastases | ||
| 520 | |a CONCLUSION: ASCP is a very rare pancreatic tumor with aggressive behavior. It is rarely diagnosed preoperatively. The best treatment, if feasible, is surgery followed by the standard chemotherapy regimens for pancreatic adenocarcinoma | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Adenoescamoso | |
| 650 | 4 | |a Adenosquamous | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Cirugía | |
| 650 | 4 | |a Cáncer | |
| 650 | 4 | |a Pancreas | |
| 650 | 4 | |a Páncreas | |
| 650 | 4 | |a Surgery | |
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| 700 | 1 | |a Serrablo-Requejo, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Laiz, Gonzalo P |e verfasserin |4 aut | |
| 700 | 1 | |a López-Guerra, Diego |e verfasserin |4 aut | |
| 700 | 1 | |a Abadía-Forcén, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Alenda, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Serradilla-Martín, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Blanco-Fernández, Gerardo |e verfasserin |4 aut | |
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